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A Disintegrin and Metalloproteases (ADAMs): Activation, Regulation and Mechanisms of Catalysis

International journal of molecular sciences, 2021-08, Vol.22 (16), p.8762

Maretzky, Thorsten

2021

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Novel functions of inactive rhomboid proteins in immunity and disease

Journal of leukocyte biology, 2019-10, Vol.106 (4), p.823-835

2019

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CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element

Nature communications, 2022-03, Vol.13 (1), p.1477-1477, Article 1477

2022

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Phosphatidylserine exposure is required for ADAM17 sheddase function

Nature communications, 2016-05, Vol.7 (1), p.11523-11523, Article 11523

2016

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iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

Proceedings of the National Academy of Sciences - PNAS, 2015-05, Vol.112 (19), p.6080-6085

2015

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iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding

Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (28), p.11433-11438

2013

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Phytochemicals Perturb Membranes and Promiscuously Alter Protein Function

ACS chemical biology, 2014-08, Vol.9 (8), p.1788-1798

2014

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Members of the Fibroblast Growth Factor Receptor Superfamily Are Proteolytically Cleaved by Two Differently Activated Metalloproteases

International journal of molecular sciences, 2021-03, Vol.22 (6), p.3165

2021

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Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis

Journal of cell science, 2017-03, Vol.130 (5), p.868-878

2017

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ADAM10 Mediates E-Cadherin Shedding and Regulates Epithelial Cell-Cell Adhesion, Migration, and β-Catenin Translocation

Proceedings of the National Academy of Sciences - PNAS, 2005-06, Vol.102 (26), p.9182-9187

2005

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Analysis of the Conditions That Affect the Selective Processing of Endogenous Notch1 by ADAM10 and ADAM17

International journal of molecular sciences, 2021-02, Vol.22 (4), p.1846

2021

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iRHOM2 is a critical pathogenic mediator of inflammatory arthritis

The Journal of clinical investigation, 2013-02, Vol.123 (2), p.928-932

2013

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Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17

Nature communications, 2011-03, Vol.2 (1), p.229-229, Article 229

2011

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Characterization of the catalytic properties of the membrane-anchored metalloproteinase ADAM9 in cell-based assays

Biochemical journal, 2017-05, Vol.474 (9), p.1467-1479

2017

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Functional Distinctions of Endometrial Cancer-Associated Mutations in the Fibroblast Growth Factor Receptor 2 Gene

Cells (Basel, Switzerland), 2023-09, Vol.12 (18), p.2227

2023

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The xenoestrogens biphenol‐A and nonylphenol differentially regulate metalloprotease‐mediated shedding of EGFR ligands

Journal of cellular physiology, 2018-03, Vol.233 (3), p.2247-2256

2018

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L1 Is Sequentially Processed by Two Differently Activated Metalloproteases and Presenilin/γ-Secretase and Regulates Neural Cell Adhesion, Cell Migration, and Neurite Outgrowth

Molecular and Cellular Biology, 2005-10, Vol.25 (20), p.9040-9053

2005

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The Role of iRhom2 in Metabolic and Cardiovascular-Related Disorders

Frontiers in cardiovascular medicine, 2020-11, Vol.7, p.612808-612808

2020

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ADAM10-Mediated E-Cadherin Release Is Regulated by Proinflammatory Cytokines and Modulates Keratinocyte Cohesion in Eczematous Dermatitis

Journal of investigative dermatology, 2008-07, Vol.128 (7), p.1737-1746

2008

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ADAM17 Controls Endochondral Ossification by Regulating Terminal Differentiation of Chondrocytes

Molecular and Cellular Biology, 2013-08, Vol.33 (16), p.3077-3090

2013

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The Threshold Effect: Lipopolysaccharide-Induced Inflammatory Responses in Primary Macrophages Are Differentially Regulated in an iRhom2-Dependent Manner

Frontiers in cellular and infection microbiology, 2021-01, Vol.10, p.620392-620392

2021

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LRRK2 G2019S Promotes Colon Cancer Potentially via LRRK2-GSDMD Axis-Mediated Gut Inflammation

Cells (Basel, Switzerland), 2024-04, Vol.13 (7), p.565

2024

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Advantages of Tyrosine Kinase Anti-Angiogenic Cediranib over Bevacizumab: Cell Cycle Abrogation and Synergy with Chemotherapy

Pharmaceuticals (Basel, Switzerland), 2021-07, Vol.14 (7), p.682

2021

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FGFR2 mutations promote endometrial cancer progression through dual engagement of EGFR and Notch signalling pathways

Clinical and translational medicine, 2023-05, Vol.13 (5), p.e1223-n/a

2023

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Src Stimulates Fibroblast Growth Factor Receptor-2 Shedding by an ADAM15 Splice Variant Linked to Breast Cancer

Cancer research (Chicago, Ill.), 2009-06, Vol.69 (11), p.4573-4576

2009

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A Disintegrin and Metalloproteases (ADAMs): Activation, Regulation and Mechanisms of Catalysis

Novel functions of inactive rhomboid proteins in immunity and disease

CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element

Phosphatidylserine exposure is required for ADAM17 sheddase function

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding

Phytochemicals Perturb Membranes and Promiscuously Alter Protein Function

Members of the Fibroblast Growth Factor Receptor Superfamily Are Proteolytically Cleaved by Two Differently Activated Metalloproteases

Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis

ADAM10 Mediates E-Cadherin Shedding and Regulates Epithelial Cell-Cell Adhesion, Migration, and β-Catenin Translocation

Analysis of the Conditions That Affect the Selective Processing of Endogenous Notch1 by ADAM10 and ADAM17

iRHOM2 is a critical pathogenic mediator of inflammatory arthritis

Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17

Characterization of the catalytic properties of the membrane-anchored metalloproteinase ADAM9 in cell-based assays

Functional Distinctions of Endometrial Cancer-Associated Mutations in the Fibroblast Growth Factor Receptor 2 Gene

The xenoestrogens biphenol‐A and nonylphenol differentially regulate metalloprotease‐mediated shedding of EGFR ligands

L1 Is Sequentially Processed by Two Differently Activated Metalloproteases and Presenilin/γ-Secretase and Regulates Neural Cell Adhesion, Cell Migration, and Neurite Outgrowth

The Role of iRhom2 in Metabolic and Cardiovascular-Related Disorders

ADAM10-Mediated E-Cadherin Release Is Regulated by Proinflammatory Cytokines and Modulates Keratinocyte Cohesion in Eczematous Dermatitis

ADAM17 Controls Endochondral Ossification by Regulating Terminal Differentiation of Chondrocytes

The Threshold Effect: Lipopolysaccharide-Induced Inflammatory Responses in Primary Macrophages Are Differentially Regulated in an iRhom2-Dependent Manner

LRRK2 G2019S Promotes Colon Cancer Potentially via LRRK2-GSDMD Axis-Mediated Gut Inflammation

Advantages of Tyrosine Kinase Anti-Angiogenic Cediranib over Bevacizumab: Cell Cycle Abrogation and Synergy with Chemotherapy

FGFR2 mutations promote endometrial cancer progression through dual engagement of EGFR and Notch signalling pathways

Src Stimulates Fibroblast Growth Factor Receptor-2 Shedding by an ADAM15 Splice Variant Linked to Breast Cancer

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