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An Activity-Based Probe for Cathepsin K Imaging with Excellent Potency and Selectivity

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13793-13806

2021

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Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure–Activity Relationship and Binding Mode Analysis

Journal of medicinal chemistry, 2020-02, Vol.63 (4), p.1576-1596

2020

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Structural and Functional Characterization of Schistosoma mansoni Cathepsin B1

Methods in molecular biology (Clifton, N.J.), 2020, Vol.2151, p.145

2020

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New insights into the machinery of blood digestion by ticks

Trends in parasitology, 2013-06, Vol.29 (6), p.276-285

2013

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Structural studies of complexes of kallikrein 4 with wild‐type and mutated forms of the Kunitz‐type inhibitor BbKI

Acta crystallographica. Section D, Biological crystallography., 2021-08, Vol.77 (8), p.1084-1098

2021

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Quantum Mechanics-Based Scoring Rationalizes the Irreversible Inactivation of Parasitic Schistosoma mansoni Cysteine Peptidase by Vinyl Sulfone Inhibitors

The journal of physical chemistry. B, 2013-12, Vol.117 (48), p.14973-14982

2013

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Digestive proteolysis in the Colorado potato beetle, Leptinotarsa decemlineata: Activity-based profiling and imaging of a multipeptidase network

Insect biochemistry and molecular biology, 2016-11, Vol.78, p.1-11

2016

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Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis

ACS infectious diseases, 2024-06, Vol.10 (6), p.1935-1948

2024

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Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors

ACS infectious diseases, 2021-05, Vol.7 (5), p.1077-1088

2021

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Mapping the Pro-Peptide of the Schistosoma mansoni Cathepsin B1 Drug Target: Modulation of Inhibition by Heparin and Design of Mimetic Inhibitors

ACS chemical biology, 2011-06, Vol.6 (6), p.609-617

2011

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Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.515-526

2022

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The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin

Cellular and molecular life sciences : CMLS, 2019-05, Vol.76 (10), p.2003-2013

2019

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An Unusual Two-Domain Thyropin from Tick Saliva: NMR Solution Structure and Highly Selective Inhibition of Cysteine Cathepsins Modulated by Glycosaminoglycans

International journal of molecular sciences, 2024-02, Vol.25 (4), p.2240

2024

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Mialostatin, a Novel Midgut Cystatin from Ixodes ricinus Ticks: Crystal Structure and Regulation of Host Blood Digestion

International journal of molecular sciences, 2021-05, Vol.22 (10), p.5371

2021

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Two Tags in One Probe: Combining Fluorescence‐ and Biotin‐based Detection of the Trypanosomal Cysteine Protease Rhodesain

Chemistry : a European journal, 2022-11, Vol.28 (62), p.e202201636-n/a

2022

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Complex modulation of peptidolytic activity of cathepsin D by sphingolipids

Biochimica et biophysica acta, 2011-12, Vol.1811 (12), p.1097-1104

2011

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Protease-bound structure of Ricistatin provides insights into the mechanism of action of tick salivary cystatins in the vertebrate host

Cellular and molecular life sciences : CMLS, 2023-11, Vol.80 (11), p.339-339, Article 339

2023

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Nuclear and mtDNA phylogenetic analyses clarify the evolutionary history of two species of native Hawaiian bats and the taxonomy of Lasiurini (Mammalia: Chiroptera)

PloS one, 2017-10, Vol.12 (10), p.e0186085-e0186085

2017

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An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily

The Journal of biological chemistry, 2023-03, Vol.299 (3), p.102970-102970, Article 102970

2023

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Differential Elicitation of Two Processing Proteases Controls the Processing Pattern of the Trypsin Proteinase Inhibitor Precursor in Nicotiana attenuata

Plant physiology (Bethesda), 2005-09, Vol.139 (1), p.375-388

2005

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Dynamics of digestive proteolytic system during blood feeding of the hard tick Ixodes ricinus

Parasites & vectors, 2010-12, Vol.3 (1), p.119-119, Article 119

2010

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A Coumarin-Labeled Vinyl Sulfone as Tripeptidomimetic Activity-Based Probe for Cysteine Cathepsins

Chembiochem : a European journal of chemical biology, 2014-05, Vol.15 (7), p.955-959

2014

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Spatial expression pattern of serine proteases in the blood fluke Schistosoma mansoni determined by fluorescence RNA in situ hybridization

Parasites & vectors, 2021-05, Vol.14 (1), p.1-274, Article 274

2021

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SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties

PLoS neglected tropical diseases, 2018-04, Vol.12 (4), p.e0006446-e0006446

2018

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Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors

PLoS neglected tropical diseases, 2015-06, Vol.9 (6), p.e0003827

2015

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An Activity-Based Probe for Cathepsin K Imaging with Excellent Potency and Selectivity

Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure–Activity Relationship and Binding Mode Analysis

Structural and Functional Characterization of Schistosoma mansoni Cathepsin B1

New insights into the machinery of blood digestion by ticks

Structural studies of complexes of kallikrein 4 with wild‐type and mutated forms of the Kunitz‐type inhibitor BbKI

Quantum Mechanics-Based Scoring Rationalizes the Irreversible Inactivation of Parasitic Schistosoma mansoni Cysteine Peptidase by Vinyl Sulfone Inhibitors

Digestive proteolysis in the Colorado potato beetle, Leptinotarsa decemlineata: Activity-based profiling and imaging of a multipeptidase network

Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis

Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors

Mapping the Pro-Peptide of the Schistosoma mansoni Cathepsin B1 Drug Target: Modulation of Inhibition by Heparin and Design of Mimetic Inhibitors

Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes

The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin

An Unusual Two-Domain Thyropin from Tick Saliva: NMR Solution Structure and Highly Selective Inhibition of Cysteine Cathepsins Modulated by Glycosaminoglycans

Mialostatin, a Novel Midgut Cystatin from Ixodes ricinus Ticks: Crystal Structure and Regulation of Host Blood Digestion

Two Tags in One Probe: Combining Fluorescence‐ and Biotin‐based Detection of the Trypanosomal Cysteine Protease Rhodesain

Complex modulation of peptidolytic activity of cathepsin D by sphingolipids

Protease-bound structure of Ricistatin provides insights into the mechanism of action of tick salivary cystatins in the vertebrate host

Nuclear and mtDNA phylogenetic analyses clarify the evolutionary history of two species of native Hawaiian bats and the taxonomy of Lasiurini (Mammalia: Chiroptera)

An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily

Differential Elicitation of Two Processing Proteases Controls the Processing Pattern of the Trypsin Proteinase Inhibitor Precursor in Nicotiana attenuata

Dynamics of digestive proteolytic system during blood feeding of the hard tick Ixodes ricinus

A Coumarin-Labeled Vinyl Sulfone as Tripeptidomimetic Activity-Based Probe for Cysteine Cathepsins

Spatial expression pattern of serine proteases in the blood fluke Schistosoma mansoni determined by fluorescence RNA in situ hybridization

SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties

Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors

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