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Catalytic Asymmetric Diazoacetate Cyclopropanation of 1-Tosyl-3-vinylindoles. A Route to Conformationally Restricted Homotryptamines

Organic letters, 2005-06, Vol.7 (13), p.2651-2654

2005

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Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780

International journal of alzheimer's disease, 2014, Vol.2014, p.431858-22

2014

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Asymmetric Construction of a Quaternary Carbon Center by Tandem [4 + 2]/[3 + 2] Cycloaddition of a Nitroalkene. The Total Synthesis of (−)-Mesembrine

Journal of organic chemistry, 1997-03, Vol.62 (6), p.1675-1686

1997

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Conformationally Restricted Homotryptamines. 2. Indole Cyclopropylmethylamines as Selective Serotonin Reuptake Inhibitors

Journal of medicinal chemistry, 2005-09, Vol.48 (19), p.6023-6034

2005

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Preclinical Characterization of ( R )-3-((3 S ,4 S )-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N -Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder

The Journal of pharmacology and experimental therapeutics, 2017-12, Vol.363 (3), p.377-393

2017

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Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

ACS medicinal chemistry letters, 2010-06, Vol.1 (3), p.120-124

2010

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Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ‑Secretase Modulator BMS-932481

ACS medicinal chemistry letters, 2019-03, Vol.10 (3), p.312-317

2019

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BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder

ACS medicinal chemistry letters, 2018-05, Vol.9 (5), p.472-477

2018

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Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia

Bioorganic & medicinal chemistry, 2017-01, Vol.25 (2), p.496-513

2017

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Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.537-541

2011

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Nitroalkene Inter [4 + 2]/Intra [3 + 2] Tandem Cycloadditions. 7. Application of (R)-(-)-2,2-Diphenylcyclopentanol as the Chiral Auxiliary

Journal of organic chemistry, 1995-05, Vol.60 (10), p.3205-3220

1995

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A general method for the preparation of 2,2-disubstituted 1-nitroalkenes

Journal of organic chemistry, 1993-07, Vol.58 (15), p.3850-3856

1993

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Nitroalkene [4+2] cycloaddition as a general and stereoselective route to the synthesis of 3,3- and 3,4-disubstituted pyrrolidines

Journal of organic chemistry, 1993-07, Vol.58 (15), p.3857-3868

1993

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Total Synthesis of (±)-Batrachotoxinin A

Journal of the American Chemical Society, 1998-07, Vol.120 (26), p.6627-6628

1998

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Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (3), p.1027-1030

2010

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Conformationally restricted homotryptamines. Part 4: Heterocyclic and naphthyl analogs of a potent selective serotonin reuptake inhibitor

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (20), p.5647-5651

2007

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Asymmetric Nitroalkene [4 + 2] Cycloadditions: Enantioselective Synthesis of 3-Substituted and 3,4-Disubstituted Pyrrolidines

Journal of organic chemistry, 1995-05, Vol.60 (10), p.3221-3235

1995

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Mitsunobu reactions of n-alkyl and n-acyl sulfonamides-an efficient route to protected amines

Tetrahedron letters, 1989, Vol.30 (42), p.5709-5712

1989

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Microwave-assisted synthesis and chiral HPLC separation of 18F-labeled MaxiPost™. An agent for post-stroke neuroprotection

Journal of labelled compounds & radiopharmaceuticals, 2003-10, Vol.46 (12), p.1161-1171

2003

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Triazolopyridine ethers as potent, orally active mGlu 2 positive allosteric modulators for treating schizophrenia

Bioorganic & medicinal chemistry, 2017-01, Vol.25 (2), p.496

2017

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Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780

Case reports in oncological medicine, 2014, Vol.2014 (2014), p.1-22

2014

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Chapter 3 Secretase Inhibitors and Modulators for the Treatment of Alzheimer's Disease

Annual Reports in Medicinal Chemistry, 2007, Vol.42, p.27-47

2007

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A useful modification of the Garst-Spencer furan annulation: An improved synthesis of 3,4-substituted furans

Tetrahedron letters, 1998-12, Vol.39 (49), p.8929-8932

1998

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Microwave‐assisted synthesis and chiral HPLC separation of 18 F‐labeled MaxiPost ™ . An agent for post‐stroke neuroprotection

Journal of labelled compounds & radiopharmaceuticals, 2003-10, Vol.46 (12), p.1161-1171

2003

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Applications of nitroalkene (4+2); cycloaddition chemistry. The asymmetric synthesis of substituted pyrrolidines and the total synthesis of mesembrine

Marcin, Lawrence R

1996

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Catalytic Asymmetric Diazoacetate Cyclopropanation of 1-Tosyl-3-vinylindoles. A Route to Conformationally Restricted Homotryptamines

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780

Asymmetric Construction of a Quaternary Carbon Center by Tandem [4 + 2]/[3 + 2] Cycloaddition of a Nitroalkene. The Total Synthesis of (−)-Mesembrine

Conformationally Restricted Homotryptamines. 2. Indole Cyclopropylmethylamines as Selective Serotonin Reuptake Inhibitors

Preclinical Characterization of ( R )-3-((3 S ,4 S )-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N -Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ‑Secretase Modulator BMS-932481

BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder

Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia

Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1

Nitroalkene Inter [4 + 2]/Intra [3 + 2] Tandem Cycloadditions. 7. Application of (R)-(-)-2,2-Diphenylcyclopentanol as the Chiral Auxiliary

A general method for the preparation of 2,2-disubstituted 1-nitroalkenes

Nitroalkene [4+2] cycloaddition as a general and stereoselective route to the synthesis of 3,3- and 3,4-disubstituted pyrrolidines

Total Synthesis of (±)-Batrachotoxinin A

Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles

Conformationally restricted homotryptamines. Part 4: Heterocyclic and naphthyl analogs of a potent selective serotonin reuptake inhibitor

Asymmetric Nitroalkene [4 + 2] Cycloadditions: Enantioselective Synthesis of 3-Substituted and 3,4-Disubstituted Pyrrolidines

Mitsunobu reactions of n-alkyl and n-acyl sulfonamides-an efficient route to protected amines

Microwave-assisted synthesis and chiral HPLC separation of 18F-labeled MaxiPost™. An agent for post-stroke neuroprotection

Triazolopyridine ethers as potent, orally active mGlu 2 positive allosteric modulators for treating schizophrenia

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780

Chapter 3 Secretase Inhibitors and Modulators for the Treatment of Alzheimer's Disease

A useful modification of the Garst-Spencer furan annulation: An improved synthesis of 3,4-substituted furans

Microwave‐assisted synthesis and chiral HPLC separation of 18 F‐labeled MaxiPost ™ . An agent for post‐stroke neuroprotection

Applications of nitroalkene (4+2); cycloaddition chemistry. The asymmetric synthesis of substituted pyrrolidines and the total synthesis of mesembrine

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