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Allostery in the dynamic coactivator domain KIX occurs through minor conformational micro-states

PLoS computational biology, 2022-04, Vol.18 (4), p.e1009977-e1009977

2022

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A Dual-Site Inhibitor of CBP/p300 KIX is a Selective and Effective Modulator of Myb

Journal of the American Chemical Society, 2021-09, Vol.143 (37), p.15056-15062

2021

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Electron‐deficient p‐benzoyl‐l‐phenylalanine derivatives increase covalent chemical capture yields for protein–protein interactions

Protein science, 2019-06, Vol.28 (6), p.1163-1170

2019

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Pharmaceutical solvate formation for the incorporation of the antimicrobial agent hydrogen peroxide

Chemical communications (Cambridge, England), 2018, Vol.54 (67), p.9286-9289

2018

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Prepaying the entropic cost for allosteric regulation in KIX

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (33), p.12067-12072

2014

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Dissecting allosteric effects of activator–coactivator complexes using a covalent small molecule ligand

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (33), p.12061-12066

2014

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TRIC: Capturing the direct cellular targets of promoter‐bound transcriptional activators

Protein science, 2016-08, Vol.25 (8), p.1371-1377

2016

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Profiling the Dynamic Interfaces of Fluorinated Transcription Complexes for Ligand Discovery and Characterization

ACS chemical biology, 2012-08, Vol.7 (8), p.1345-1350

2012

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Transcriptional Switches: Chemical Approaches to Gene Regulation

The Journal of biological chemistry, 2010-04, Vol.285 (15), p.11033-11038

2010

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BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability

Bioorganic & medicinal chemistry, 2018-07, Vol.26 (11), p.2937-2957

2018

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Modulating the masters: chemical tools to dissect CBP and p300 function

Current opinion in chemical biology, 2018-08, Vol.45, p.195-203

2018

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Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300

Angewandte Chemie (International ed.), 2012-11, Vol.51 (45), p.11258-11262

International ed. in English, 2012

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Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks

Frontiers in bioengineering and biotechnology, 2015-01, Vol.3, p.119-119

2015

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Selective Modulation of Dynamic Protein Complexes

Cell chemical biology, 2020-08, Vol.27 (8), p.986-997

2020

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Sequence context and crosslinking mechanism affect the efficiency of in vivo capture of a protein-protein interaction

Biopolymers, 2014-04, Vol.101 (4), p.391-397

2014

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From Fuzzy to Function: The New Frontier of Protein–Protein Interactions

Accounts of chemical research, 2017-03, Vol.50 (3), p.584-589

2017

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Caught in the Act: Covalent Cross-Linking Captures Activator–Coactivator Interactions in Vivo

ACS chemical biology, 2011-12, Vol.6 (12), p.1321-1326

2011

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A TAD Further: Exogenous Control of Gene Activation

ACS chemical biology, 2007-01, Vol.2 (1), p.62-75

2007

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Targeting transcription is no longer a quixotic quest

Nature chemical biology, 2015-12, Vol.11 (12), p.891

2015

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Activation of Gene Expression by Small Molecule Transcription Factors

Proceedings of the National Academy of Sciences - PNAS, 2000-04, Vol.97 (8), p.3930-3935

2000

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Impact of Nonnatural Amino Acid Mutagenesis on the in Vivo Function and Binding Modes of a Transcriptional Activator

Journal of the American Chemical Society, 2009-10, Vol.131 (40), p.14240-14242

2009

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Unexpected specificity within dynamic transcriptional protein–protein complexes

Proceedings of the National Academy of Sciences - PNAS, 2020-11, Vol.117 (44), p.27346-27353

2020

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Transcriptional tools: Small molecules for modulating CBP KIX-dependent transcriptional activators

Biopolymers, 2011-01, Vol.95 (1), p.17-23

2011

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Inhibition of CREB Binding and Function with a Dual-Targeting Ligand

Biochemistry (Easton), 2024-01, Vol.63 (1), p.1-8

2024

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The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia

Science translational medicine, 2021-04, Vol.13 (590)

2021

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Allostery in the dynamic coactivator domain KIX occurs through minor conformational micro-states

A Dual-Site Inhibitor of CBP/p300 KIX is a Selective and Effective Modulator of Myb

Electron‐deficient p‐benzoyl‐l‐phenylalanine derivatives increase covalent chemical capture yields for protein–protein interactions

Pharmaceutical solvate formation for the incorporation of the antimicrobial agent hydrogen peroxide

Prepaying the entropic cost for allosteric regulation in KIX

Dissecting allosteric effects of activator–coactivator complexes using a covalent small molecule ligand

TRIC: Capturing the direct cellular targets of promoter‐bound transcriptional activators

Profiling the Dynamic Interfaces of Fluorinated Transcription Complexes for Ligand Discovery and Characterization

Transcriptional Switches: Chemical Approaches to Gene Regulation

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability

Modulating the masters: chemical tools to dissect CBP and p300 function

Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300

Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks

Selective Modulation of Dynamic Protein Complexes

Sequence context and crosslinking mechanism affect the efficiency of in vivo capture of a protein-protein interaction

From Fuzzy to Function: The New Frontier of Protein–Protein Interactions

Caught in the Act: Covalent Cross-Linking Captures Activator–Coactivator Interactions in Vivo

A TAD Further: Exogenous Control of Gene Activation

Targeting transcription is no longer a quixotic quest

Activation of Gene Expression by Small Molecule Transcription Factors

Impact of Nonnatural Amino Acid Mutagenesis on the in Vivo Function and Binding Modes of a Transcriptional Activator

Unexpected specificity within dynamic transcriptional protein–protein complexes

Transcriptional tools: Small molecules for modulating CBP KIX-dependent transcriptional activators

Inhibition of CREB Binding and Function with a Dual-Targeting Ligand

The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia

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