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Common corruption of the mTOR signaling network in human tumors

Oncogene, 2008-12, Vol.27 (S2), p.S43-S51

2008

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Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP

Oncogene, 2016-03, Vol.35 (10), p.1250-1260

2016

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Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response

Cell death and differentiation, 2014-05, Vol.21 (5), p.836-844

2014

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United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling

Biochemical Society transactions, 2003-06, Vol.31 (Pt 3), p.573

2003

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Targeting the PI3K-Akt pathway in human cancer: Rationale and promise

Cancer cell, 2003-10, Vol.4 (4), p.257-262

2003

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The LKB1 tumor suppressor negatively regulates mTOR signaling

Cancer cell, 2004-07, Vol.6 (1), p.91-99

2004

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Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

Molecular cell, 2002-07, Vol.10 (1), p.151-162

2002

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Tuberous Sclerosis Complex-1 and -2 Gene Products Function Together to Inhibit Mammalian Target of Rapamycin (mTOR)-Mediated Downstream Signaling

Proceedings of the National Academy of Sciences - PNAS, 2002-10, Vol.99 (21), p.13571-13576

2002

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Late-presenting appendicitis: A laparoscopic approach to a complicated problem

Surgical endoscopy, 2003-05, Vol.17 (5), p.725-729

2003

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AKT/PKB Signaling: Navigating Downstream

Cell, 2007-06, Vol.129 (7), p.1261-1274

2007

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Balancing Akt with S6K: Implications for Both Metabolic Diseases and Tumorigenesis

The Journal of cell biology, 2004-11, Vol.167 (3), p.399-403

Manning, Brendan D.

2004

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The Rho-GEF Rom2p localizes to sites of polarized cell growth and participates in cytoskeletal functions in Saccharomyces cerevisiae

Molecular biology of the cell, 1997-10, Vol.8 (10), p.1829-1844

1997

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Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways

Human molecular genetics, 2005-10, Vol.14 (suppl-2), p.R251-R258

2005

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Drivers and passengers wanted! The role of kinesin-associated proteins

Trends in Cell Biology, 2000-07, Vol.10 (7), p.281-289

2000

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The Kar3p kinesin-related protein forms a novel heterodimeric structure with its associated protein Cik1p

Molecular biology of the cell, 2000-07, Vol.11 (7), p.2373-2385

2000

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Rheb fills a GAP between TSC and TOR

Trends in biochemical sciences (Amsterdam. Regular ed.), 2003-11, Vol.28 (11), p.573-576

2003

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Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

Current biology, 2003-08, Vol.13 (15), p.1259-1268

2003

Volltextzugriff (PDF)

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Genes & development, 2004-12, Vol.18 (23), p.2893-2904

2004

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Combining Functional and Tubular Damage Biomarkers Improves Diagnostic Precision for Acute Kidney Injury After Cardiac Surgery

Journal of the American College of Cardiology, 2014-12, Vol.64 (25), p.2753-2762

2014

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Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

Genes & development, 2005-08, Vol.19 (15), p.1773-1778

2005

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Late-presenting appendicitis

Surgical endoscopy, 2003-05, Vol.17 (5), p.725-729

2003

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Risk Factors for Mortality and Morbidity After the Neonatal Blalock-Taussig Shunt Procedure

The Annals of thoracic surgery, 2011-08, Vol.92 (2), p.642-652

2011

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Improved outcomes with peritoneal dialysis catheter placement after cardiopulmonary bypass in infants

The Journal of thoracic and cardiovascular surgery, 2015-01, Vol.149 (1), p.230-236

2015

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One slide fits all: The versatility of slide tracheoplasty with cardiopulmonary bypass support for airway reconstruction in children

The Journal of thoracic and cardiovascular surgery, 2011, Vol.141 (1), p.155-161

2011

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When is palliation permanent?

The Journal of thoracic and cardiovascular surgery, 2015-06, Vol.149 (6), p.1530-1531

Manning, Peter B., MD

2015

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Common corruption of the mTOR signaling network in human tumors

Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP

Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response

United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling

Targeting the PI3K-Akt pathway in human cancer: Rationale and promise

The LKB1 tumor suppressor negatively regulates mTOR signaling

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

Tuberous Sclerosis Complex-1 and -2 Gene Products Function Together to Inhibit Mammalian Target of Rapamycin (mTOR)-Mediated Downstream Signaling

Late-presenting appendicitis: A laparoscopic approach to a complicated problem

AKT/PKB Signaling: Navigating Downstream

Balancing Akt with S6K: Implications for Both Metabolic Diseases and Tumorigenesis

The Rho-GEF Rom2p localizes to sites of polarized cell growth and participates in cytoskeletal functions in Saccharomyces cerevisiae

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways

Drivers and passengers wanted! The role of kinesin-associated proteins

The Kar3p kinesin-related protein forms a novel heterodimeric structure with its associated protein Cik1p

Rheb fills a GAP between TSC and TOR

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Combining Functional and Tubular Damage Biomarkers Improves Diagnostic Precision for Acute Kidney Injury After Cardiac Surgery

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

Late-presenting appendicitis

Risk Factors for Mortality and Morbidity After the Neonatal Blalock-Taussig Shunt Procedure

Improved outcomes with peritoneal dialysis catheter placement after cardiopulmonary bypass in infants

One slide fits all: The versatility of slide tracheoplasty with cardiopulmonary bypass support for airway reconstruction in children

When is palliation permanent?

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