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Alterations of the gut microbiota with antibiotics protects dopamine neuron loss and improve motor deficits in a pharmacological rodent model of Parkinson's disease

Experimental neurology, 2020-03, Vol.325, p.113159, Article 113159

2020

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A comprehensive study of a 29-capsid AAV library in a non-human primate central nervous system

Molecular therapy, 2021-09, Vol.29 (9), p.2806-2820

2021

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phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson disease

Proceedings of the National Academy of Sciences - PNAS, 2008-01, Vol.105 (2), p.763-768

2008

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The Future of GDNF in Parkinson's Disease

Frontiers in aging neuroscience, 2020-12, Vol.12, p.593572-593572

2020

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Nigrostriatal α-Synucleinopathy Induced by Viral Vector-Mediated Overexpression of Human α-Synuclein: A New Primate Model of Parkinson's Disease

Proceedings of the National Academy of Sciences - PNAS, 2003-03, Vol.100 (5), p.2884-2889

2003

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Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice

Molecular therapy, 2005-10, Vol.12 (4), p.618-633

2005

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Correction: Site-specific modifications to AAV8 capsid yields enhanced brain transduction in the neonatal MPS IIIB mouse

Gene therapy, 2023-09, Vol.30 (9), p.736-736

2023

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Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain

Brain (London, England : 1878), 2007-03, Vol.130 (3), p.799-815

2007

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Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions

Current gene therapy, 2007-10, Vol.7 (5), p.347-360

2007

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In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration

Molecular therapy, 2010-08, Vol.18 (8), p.1450-1457

2010

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Site-specific modifications to AAV8 capsid yields enhanced brain transduction in the neonatal MPS IIIB mouse

Gene therapy, 2021-08, Vol.28 (7-8), p.447-455

2021

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Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display Differential Efficiency and Cell Tropism after Delivery to Different Regions of the Central Nervous System

Molecular therapy, 2004-08, Vol.10 (2), p.302-317

2004

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Time Course of Transgene Expression After Intrastriatal Pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 Transduction in the Rat

Molecular therapy, 2007-08, Vol.15 (8), p.1504-1511

2007

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Circulating Anti-Wild-Type Adeno-Associated Virus Type 2 (AAV2) Antibodies Inhibit Recombinant AAV2 (rAAV2)-Mediated, but Not rAAV5-Mediated, Gene Transfer in the Brain

Journal of Virology, 2004-06, Vol.78 (12), p.6344-6359

2004

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Continuous Low-Level Glial Cell Line-Derived Neurotrophic Factor Delivery Using Recombinant Adeno-Associated Viral Vectors Provides Neuroprotection and Induces Behavioral Recovery in a Primate Model of Parkinson's Disease

The Journal of neuroscience, 2005-01, Vol.25 (4), p.769-777

2005

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Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of alpha -Synuclein in the Nigrostriatal System

The Journal of neuroscience, 2002-04, Vol.22 (7), p.2780-2791

2002

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Regulated protein expression for in vivo gene therapy for neurological disorders: Progress, strategies, and issues

Neurobiology of disease, 2012-11, Vol.48 (2), p.212-221

2012

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Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates

Molecular therapy, 2010-03, Vol.18 (3), p.579-587

2010

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AAV9: a potential blood-brain barrier buster

Molecular therapy, 2009-03, Vol.17 (3), p.403-405

2009

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Recombinant adeno-associated viral vectors in the nervous system

Human gene therapy, 2005-07, Vol.16 (7), p.781-791

2005

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Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data

Lancet neurology, 2006-11, Vol.5 (11), p.911-916

2006

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Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates

Acta neuropathologica communications, 2017-06, Vol.5 (1), p.47-47, Article 47

2017

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Tight Long-term Dynamic Doxycycline Responsive Nigrostriatal GDNF Using a Single rAAV Vector

Molecular therapy, 2009-11, Vol.17 (11), p.1857-1867

2009

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Recombinant Adeno-associated Viral Vectors as Therapeutic Agents to Treat Neurological Disorders

Molecular therapy, 2006-03, Vol.13 (3), p.463-483

2006

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Long-Term rAAV-Mediated Gene Transfer of GDNF in the Rat Parkinson's Model: Intrastriatal But Not Intranigral Transduction Promotes Functional Regeneration in the Lesioned Nigrostriatal System

The Journal of neuroscience, 2000-06, Vol.20 (12), p.4686-4700

2000

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Alterations of the gut microbiota with antibiotics protects dopamine neuron loss and improve motor deficits in a pharmacological rodent model of Parkinson's disease

A comprehensive study of a 29-capsid AAV library in a non-human primate central nervous system

phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson disease

The Future of GDNF in Parkinson's Disease

Nigrostriatal α-Synucleinopathy Induced by Viral Vector-Mediated Overexpression of Human α-Synuclein: A New Primate Model of Parkinson's Disease

Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice

Correction: Site-specific modifications to AAV8 capsid yields enhanced brain transduction in the neonatal MPS IIIB mouse

Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain

Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions

In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration

Site-specific modifications to AAV8 capsid yields enhanced brain transduction in the neonatal MPS IIIB mouse

Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display Differential Efficiency and Cell Tropism after Delivery to Different Regions of the Central Nervous System

Time Course of Transgene Expression After Intrastriatal Pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 Transduction in the Rat

Circulating Anti-Wild-Type Adeno-Associated Virus Type 2 (AAV2) Antibodies Inhibit Recombinant AAV2 (rAAV2)-Mediated, but Not rAAV5-Mediated, Gene Transfer in the Brain

Continuous Low-Level Glial Cell Line-Derived Neurotrophic Factor Delivery Using Recombinant Adeno-Associated Viral Vectors Provides Neuroprotection and Induces Behavioral Recovery in a Primate Model of Parkinson's Disease

Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of alpha -Synuclein in the Nigrostriatal System

Regulated protein expression for in vivo gene therapy for neurological disorders: Progress, strategies, and issues

Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates

AAV9: a potential blood-brain barrier buster

Recombinant adeno-associated viral vectors in the nervous system

Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data

Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates

Tight Long-term Dynamic Doxycycline Responsive Nigrostriatal GDNF Using a Single rAAV Vector

Recombinant Adeno-associated Viral Vectors as Therapeutic Agents to Treat Neurological Disorders

Long-Term rAAV-Mediated Gene Transfer of GDNF in the Rat Parkinson's Model: Intrastriatal But Not Intranigral Transduction Promotes Functional Regeneration in the Lesioned Nigrostriatal System

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