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Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer

International journal of radiation oncology, biology, physics, 2018-03, Vol.100 (4), p.1034-1043

2018

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Potent and Selective Phosphopeptide Mimetic Prodrugs Targeted to the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3

Journal of medicinal chemistry, 2011-05, Vol.54 (10), p.3549-3563

2011

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Crystal structure of unphosphorylated STAT3 core fragment

Biochemical and biophysical research communications, 2008-09, Vol.374 (1), p.1-5

2008

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Long-Acting Beta Agonists Enhance Allergic Airway Disease

PloS one, 2015-11, Vol.10 (11), p.e0142212-e0142212

2015

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Synthesis and in Vitro Evaluation of a Peptidomimetic Inhibitor Targeting the Src Homology 2 (SH2) Domain of STAT6

ACS medicinal chemistry letters, 2014-01, Vol.5 (1), p.69-72

2014

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Investigation of the Binding Determinants of Phosphopeptides Targeted to the Src Homology 2 Domain of the Signal Transducer and Activator of Transcription 3. Development of a High-Affinity Peptide Inhibitor

Journal of medicinal chemistry, 2005-10, Vol.48 (21), p.6661-6670

2005

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Pd−C-Induced Catalytic Transfer Hydrogenation with Triethylsilane

Journal of organic chemistry, 2007-08, Vol.72 (17), p.6599-6601

2007

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Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme

Journal of medicinal chemistry, 2021-08, Vol.64 (15), p.11302-11329

2021

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STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13

Nature communications, 2014-12, Vol.5 (1), p.5798-5798, Article 5798

2014

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Hydrodehalogenation of Alkyl Iodides with Base-Mediated Hydrogenation and Catalytic Transfer Hydrogenation: Application to the Asymmetric Synthesis of N‑Protected α‑Methylamines

Journal of organic chemistry, 2014-09, Vol.79 (17), p.8422-8427

2014

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Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity

Journal of medicinal chemistry, 2015-11, Vol.58 (22), p.8970-8984

2015

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The Bile Acid-Activated Phosphatidylinositol 3-Kinase Pathway Inhibits Fas Apoptosis Upstream of Bid in Rodent Hepatocytes

Gastroenterology (New York, N.Y. 1943), 2001-06, Vol.120 (7), p.1810-1817

2001

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Synthesis of Phosphatase-Stable, Cell-Permeable Peptidomimetic Prodrugs That Target the SH2 Domain of Stat3

Organic letters, 2009-08, Vol.11 (15), p.3394-3397

2009

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Conformationally Constrained Peptidomimetic Inhibitors of Signal Transducer and Activator of Transcription 3: Evaluation and Molecular Modeling

Journal of medicinal chemistry, 2009-04, Vol.52 (8), p.2429-2442

2009

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Efficient synthesis of apricoxib, CS-706, a selective cyclooxygenase-2 inhibitor, and evaluation of inhibition of prostaglandin E2 production in inflammatory breast cancer cells

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (20), p.6071-6073

2011

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Long-Acting Beta Agonists Enhance Allergic Airway Disease

Journal of allergy and clinical immunology, 2015-02, Vol.135 (2), p.AB381-AB381

2015

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A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis

Journal of experimental therapeutics & oncology, 2012, Vol.10 (2), p.155-162

2012

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Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (3), p.654-656

2007

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Structure–Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3)

International journal of peptide research and therapeutics, 2013-03, Vol.19 (1), p.3-12

2013

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Model of Intermolecular Interactions between High Affinity Phosphopeptides and Stat3

Advances in experimental medicine and biology, 2009, Vol.611, p.543-544

2009

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Application of Triethylsilane and Palladium-Charcoal-Induced Reductions in the Synthesis of Fmoc-Glutamic Acid Analogues

Advances in experimental medicine and biology, 2009, Vol.611, p.181-182

2009

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Inhibition of Stat3 by Cell-Permeable Peptidomimetic Prodrugs Targeted to its SH2 Domain

Advances in experimental medicine and biology, 2009, Vol.611, p.545-546

2009

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The consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domain

JAK-STAT, 2012-10, Vol.1 (4), p.263-347

2012

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Abstract 4838: Peptide prodrugs targeting the SH2 domains of p85 block PI3K signaling

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4838-4838

2016

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Allosteric SHP2 inhibitor IACS-13909 overcomes EGFR-dependent and EGFR-independent resistance mechanisms towards osimertinib

Cancer research (Chicago, Ill.), 2020-09, Vol.80 (21), p.4840-4853

2020

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Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer

Potent and Selective Phosphopeptide Mimetic Prodrugs Targeted to the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3

Crystal structure of unphosphorylated STAT3 core fragment

Long-Acting Beta Agonists Enhance Allergic Airway Disease

Synthesis and in Vitro Evaluation of a Peptidomimetic Inhibitor Targeting the Src Homology 2 (SH2) Domain of STAT6

Investigation of the Binding Determinants of Phosphopeptides Targeted to the Src Homology 2 Domain of the Signal Transducer and Activator of Transcription 3. Development of a High-Affinity Peptide Inhibitor

Pd−C-Induced Catalytic Transfer Hydrogenation with Triethylsilane

Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme

STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13

Hydrodehalogenation of Alkyl Iodides with Base-Mediated Hydrogenation and Catalytic Transfer Hydrogenation: Application to the Asymmetric Synthesis of N‑Protected α‑Methylamines

Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity

The Bile Acid-Activated Phosphatidylinositol 3-Kinase Pathway Inhibits Fas Apoptosis Upstream of Bid in Rodent Hepatocytes

Synthesis of Phosphatase-Stable, Cell-Permeable Peptidomimetic Prodrugs That Target the SH2 Domain of Stat3

Conformationally Constrained Peptidomimetic Inhibitors of Signal Transducer and Activator of Transcription 3: Evaluation and Molecular Modeling

Efficient synthesis of apricoxib, CS-706, a selective cyclooxygenase-2 inhibitor, and evaluation of inhibition of prostaglandin E2 production in inflammatory breast cancer cells

Long-Acting Beta Agonists Enhance Allergic Airway Disease

A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis

Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics

Structure–Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3)

Model of Intermolecular Interactions between High Affinity Phosphopeptides and Stat3

Application of Triethylsilane and Palladium-Charcoal-Induced Reductions in the Synthesis of Fmoc-Glutamic Acid Analogues

Inhibition of Stat3 by Cell-Permeable Peptidomimetic Prodrugs Targeted to its SH2 Domain

The consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domain

Abstract 4838: Peptide prodrugs targeting the SH2 domains of p85 block PI3K signaling

Allosteric SHP2 inhibitor IACS-13909 overcomes EGFR-dependent and EGFR-independent resistance mechanisms towards osimertinib

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