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Vinyl Sulfone-Based Peptidomimetics as Anti-Trypanosomal Agents: Design, Synthesis, Biological and Computational Evaluation

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.6638-6650

2013

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Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans

The American journal of clinical nutrition, 2006-09, Vol.84 (3), p.531-539

2006

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Kinetic Studies of the Effect of pH on the Trypsin-Catalyzed Hydrolysis of N‑α-benzyloxycarbonyl‑l‑lysine‑p‑nitroanilide: Mechanism of Trypsin Catalysis

ACS omega, 2020-03, Vol.5 (10), p.4915-4923

Malthouse, J. Paul G

2020

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Importance of Tetrahedral Intermediate Formation in the Catalytic Mechanism of the Serine Proteases Chymotrypsin and Subtilisin

Biochemistry (Easton), 2012-08, Vol.51 (31), p.6164-6170

2012

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Synthesis of 2-guanidinyl pyridines and their trypsin inhibition and docking

Bioorganic & medicinal chemistry, 2020-08, Vol.28 (16), p.115612-115612, Article 115612

2020

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Prolonged L -alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic β-cells

Clinical science (1979), 2009-02, Vol.116 (4), p.341-351

2009

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Mechanism of the binding of Z–L-tryptophan and Z–L-phenylalanine to thermolysin and stromelysin-1 in aqueous solutions

Biochimica et biophysica acta, 2012-02, Vol.1824 (2), p.303-310

2012

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pH stability of the stromelysin-1 catalytic domain and its mechanism of interaction with a glyoxal inhibitor

Biochimica et biophysica acta, 2011-10, Vol.1814 (10), p.1394-1403

2011

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A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic β-cell line metabolism of L-alanine is important to the regulation of insulin secretion

Diabetes (New York, N.Y.), 2002-06, Vol.51 (6), p.1714-1721

2002

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Conformational, receptor interaction and alanine scan studies of glucose-dependent insulinotropic polypeptide

Biochimica et biophysica acta, 2011-07, Vol.1814 (7), p.882-888

2011

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The bioactive conformation of glucose-dependent insulinotropic polypeptide by NMR and CD spectroscopy

Proteins, structure, function, and bioinformatics, 2007-07, Vol.68 (1), p.92-99

2007

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A new lysine derived glyoxal inhibitor of trypsin, its properties and utilization for studying the stabilization of tetrahedral adducts by trypsin

Biochemistry and biophysics reports, 2016-03, Vol.5 (C), p.272-284

2016

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NMR and Alanine Scan Studies of Glucose-dependent Insulinotropic Polypeptide in Water

The Journal of biological chemistry, 2006-06, Vol.281 (24), p.16370-16376

2006

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Quantifying tetrahedral adduct formation and stabilization in the cysteine and the serine proteases

Biochimica et biophysica acta, 2015-10, Vol.1854 (10), p.1382-1391

2015

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Determination of the Structure of Tetrahedral Transition State Analogues Bound at the Active Site of Chymotrypsin Using 18O and 2H Isotope Shifts in the 13C NMR Spectra of Glyoxal Inhibitors

Biochemistry (Easton), 2007-11, Vol.46 (44), p.12868-12874

2007

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NMR Study of the Inhibition of Pepsin by Glyoxal Inhibitors: Mechanism of Tetrahedral Intermediate Stabilization by the Aspartyl Proteases

Biochemistry (Easton), 2007-10, Vol.46 (39), p.11205-11215

2007

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Hemiacetal stabilization in a chymotrypsin inhibitor complex and the reactivity of the hydroxyl group of the catalytic serine residue of chymotrypsin

Biochimica et biophysica acta, 2014-06, Vol.1844 (6), p.1119-1127

2014

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Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study

Neurochemistry international, 2004-12, Vol.45 (8), p.1155-1165

2004

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13C and 1H NMR Studies of Ionizations and Hydrogen Bonding in Chymotrypsin-Glyoxal Inhibitor Complexes

The Journal of biological chemistry, 2007-03, Vol.282 (11), p.7852-7861

2007

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Claisen-Type Addition of Glycine to Pyridoxal in Water

Journal of the American Chemical Society, 2004-09, Vol.126 (34), p.10538-10539

2004

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The stereospecificity and catalytic efficiency of the tryptophan synthase-catalysed exchange of the alpha-protons of amino acids

Biochemical journal, 2004-08, Vol.381 (Pt 3), p.847-852

2004

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Effect of Chromium(VI) Toxicity on Enzymes of Nitrogen Metabolism in Clusterbean (Cyamopsis tetragonoloba L.)

Enzyme Research, 2014, Vol.2014 (2014), p.784036-9

2014

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Impact of the gliotoxin l-serine- O-sulphate on cellular metabolism in cultured rat astrocytes

Neurochemistry international, 2006-06, Vol.48 (8), p.739-745

2006

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Modulation of Aromatase by Phytoestrogens

Enzyme Research, 2015, Vol.2015, p.594656-11

2015

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Oxyanion and tetrahedral intermediate stabilisation by subtilisin: Detection of a new tetrahedral adduct

Biochimica et biophysica acta, 2009-08, Vol.1794 (8), p.1251-1258

2009

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Vinyl Sulfone-Based Peptidomimetics as Anti-Trypanosomal Agents: Design, Synthesis, Biological and Computational Evaluation

Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans

Kinetic Studies of the Effect of pH on the Trypsin-Catalyzed Hydrolysis of N‑α-benzyloxycarbonyl‑l‑lysine‑p‑nitroanilide: Mechanism of Trypsin Catalysis

Importance of Tetrahedral Intermediate Formation in the Catalytic Mechanism of the Serine Proteases Chymotrypsin and Subtilisin

Synthesis of 2-guanidinyl pyridines and their trypsin inhibition and docking

Prolonged L -alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic β-cells

Mechanism of the binding of Z–L-tryptophan and Z–L-phenylalanine to thermolysin and stromelysin-1 in aqueous solutions

pH stability of the stromelysin-1 catalytic domain and its mechanism of interaction with a glyoxal inhibitor

A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic β-cell line metabolism of L-alanine is important to the regulation of insulin secretion

Conformational, receptor interaction and alanine scan studies of glucose-dependent insulinotropic polypeptide

The bioactive conformation of glucose-dependent insulinotropic polypeptide by NMR and CD spectroscopy

A new lysine derived glyoxal inhibitor of trypsin, its properties and utilization for studying the stabilization of tetrahedral adducts by trypsin

NMR and Alanine Scan Studies of Glucose-dependent Insulinotropic Polypeptide in Water

Quantifying tetrahedral adduct formation and stabilization in the cysteine and the serine proteases

Determination of the Structure of Tetrahedral Transition State Analogues Bound at the Active Site of Chymotrypsin Using 18O and 2H Isotope Shifts in the 13C NMR Spectra of Glyoxal Inhibitors

NMR Study of the Inhibition of Pepsin by Glyoxal Inhibitors: Mechanism of Tetrahedral Intermediate Stabilization by the Aspartyl Proteases

Hemiacetal stabilization in a chymotrypsin inhibitor complex and the reactivity of the hydroxyl group of the catalytic serine residue of chymotrypsin

Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study

13C and 1H NMR Studies of Ionizations and Hydrogen Bonding in Chymotrypsin-Glyoxal Inhibitor Complexes

Claisen-Type Addition of Glycine to Pyridoxal in Water

The stereospecificity and catalytic efficiency of the tryptophan synthase-catalysed exchange of the alpha-protons of amino acids

Effect of Chromium(VI) Toxicity on Enzymes of Nitrogen Metabolism in Clusterbean (Cyamopsis tetragonoloba L.)

Impact of the gliotoxin l-serine- O-sulphate on cellular metabolism in cultured rat astrocytes

Modulation of Aromatase by Phytoestrogens

Oxyanion and tetrahedral intermediate stabilisation by subtilisin: Detection of a new tetrahedral adduct

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