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Drug Repositioning in Friedreich Ataxia

Frontiers in neuroscience, 2022-02, Vol.16, p.814445-814445

2022

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Interferon Gamma Enhances Cytoprotective Pathways via Nrf2 and MnSOD Induction in Friedreich’s Ataxia Cells

International journal of molecular sciences, 2023-08, Vol.24 (16), p.12687

2023

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Hyaluronic Acid (HA), Platelet-Rich Plasm and Extracorporeal Shock Wave Therapy (ESWT) promote human chondrocyte regeneration in vitro and ESWT-mediated increase of CD44 expression enhances their susceptibility to HA treatment

PloS one, 2019-01, Vol.14 (6), p.e0218740-e0218740

2019

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An RNA-seq study in Friedreich ataxia patients identified hsa-miR-148a-3p as a putative prognostic biomarker of the disease

Human genomics, 2024-05, Vol.18 (1), p.50-12, Article 50

2024

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E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia

Cell reports (Cambridge), 2017-02, Vol.18 (8), p.2007-2017

2017

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Molecular control of the cytosolic aconitase/IRP1 switch by extramitochondrial frataxin

Human molecular genetics, 2010-04, Vol.19 (7), p.1221-1229

2010

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Highly specific ubiquitin-competing molecules effectively promote frataxin accumulation and partially rescue the aconitase defect in Friedreich ataxia cells

Neurobiology of disease, 2015-03, Vol.75, p.91-99

2015

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Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans

Experimental gerontology, 2013-02, Vol.48 (2), p.191-201

2013

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A Pool of Extramitochondrial Frataxin That Promotes Cell Survival

The Journal of biological chemistry, 2006-06, Vol.281 (24), p.16750-16756

2006

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Recovery of immunological homeostasis positively correlates both with early stages of right-colorectal cancer and laparoscopic surgery

PloS one, 2013-09, Vol.8 (9), p.e74455-e74455

2013

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Differential regulation of apoptotic cell death in senescent human cells

Experimental gerontology, 2004-11, Vol.39 (11), p.1713-1721

2004

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Requirement for GD3 Ganglioside in CD95- and Ceramide-Induced Apoptosis

Science (American Association for the Advancement of Science), 1997-09, Vol.277 (5332), p.1652-1655

1997

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Acetylation suppresses the proapoptotic activity of GD3 ganglioside

The Journal of experimental medicine, 2002-12, Vol.196 (12), p.1535-1541

2002

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GD3 ganglioside directly targets mitochondria in a bcl‐2‐controlled fashion

The FASEB journal, 2000-10, Vol.14 (13), p.2047-2054

2000

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Ceramide catabolism critically controls survival of human dendritic cells

Journal of leukocyte biology, 2006-01, Vol.79 (1), p.166-172

2006

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Within Germinal Centers, Isotype Switching of Immunoglobulin Genes Occurs after the Onset of Somatic Mutation

Immunity (Cambridge, Mass.), 1996-03, Vol.4 (3), p.241-250

1996

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Hyaluronic Acid promote human chondrocyte regeneration in vitro and ESWT-mediated increase of CD44 expression enhances their susceptibility to HA treatment

PloS one, 2019-06, Vol.14 (6), p.e0218740

2019

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Hyaluronic Acid

PloS one, 2019-06, Vol.14 (6), p.e0218740

2019

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Hsa-miR223-3p circulating level is upregulated in Friedreich’s ataxia and inversely associated with HCLS1 associated protein X-1, HAX-1

Human molecular genetics, 2022-06, Vol.31 (12), p.2010-2022

2022

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Mitochondrial lipids as apoptosis regulators

Current medicinal chemistry, 2003-08, Vol.10 (16), p.1573-1580

2003

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Drug repositioning screening identifies etravirine as a potential therapeutic for friedreich's ataxia

Movement disorders, 2019-03, Vol.34 (3), p.323-334

2019

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In vivo maturation of human frataxin

Human molecular genetics, 2007-07, Vol.16 (13), p.1534-1540

2007

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GD3 ganglioside and apoptosis

BBA - Molecular and Cell Biology of Lipids, 2002-12, Vol.1585 (2), p.179-187

2002

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Interferon gamma upregulates frataxin and corrects the functional deficits in a Friedreich ataxia model

Human molecular genetics, 2012-07, Vol.21 (13), p.2855-2861

2012

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Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs)

Oncotarget, 2016-02, Vol.7 (6), p.6410-6423

2016

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Drug Repositioning in Friedreich Ataxia

Interferon Gamma Enhances Cytoprotective Pathways via Nrf2 and MnSOD Induction in Friedreich’s Ataxia Cells

Hyaluronic Acid (HA), Platelet-Rich Plasm and Extracorporeal Shock Wave Therapy (ESWT) promote human chondrocyte regeneration in vitro and ESWT-mediated increase of CD44 expression enhances their susceptibility to HA treatment

An RNA-seq study in Friedreich ataxia patients identified hsa-miR-148a-3p as a putative prognostic biomarker of the disease

E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia

Molecular control of the cytosolic aconitase/IRP1 switch by extramitochondrial frataxin

Highly specific ubiquitin-competing molecules effectively promote frataxin accumulation and partially rescue the aconitase defect in Friedreich ataxia cells

Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans

A Pool of Extramitochondrial Frataxin That Promotes Cell Survival

Recovery of immunological homeostasis positively correlates both with early stages of right-colorectal cancer and laparoscopic surgery

Differential regulation of apoptotic cell death in senescent human cells

Requirement for GD3 Ganglioside in CD95- and Ceramide-Induced Apoptosis

Acetylation suppresses the proapoptotic activity of GD3 ganglioside

GD3 ganglioside directly targets mitochondria in a bcl‐2‐controlled fashion

Ceramide catabolism critically controls survival of human dendritic cells

Within Germinal Centers, Isotype Switching of Immunoglobulin Genes Occurs after the Onset of Somatic Mutation

Hyaluronic Acid promote human chondrocyte regeneration in vitro and ESWT-mediated increase of CD44 expression enhances their susceptibility to HA treatment

Hyaluronic Acid

Hsa-miR223-3p circulating level is upregulated in Friedreich’s ataxia and inversely associated with HCLS1 associated protein X-1, HAX-1

Mitochondrial lipids as apoptosis regulators

Drug repositioning screening identifies etravirine as a potential therapeutic for friedreich's ataxia

In vivo maturation of human frataxin

GD3 ganglioside and apoptosis

Interferon gamma upregulates frataxin and corrects the functional deficits in a Friedreich ataxia model

Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs)

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