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Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

Immunity (Cambridge, Mass.), 2010-08, Vol.33 (2), p.153-165

2010

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The biology of interleukin-2

Annual review of immunology, 2008-01, Vol.26 (1), p.453-479

Malek, Thomas R

2008

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Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells

Nature communications, 2019-03, Vol.10 (1), p.1037-1037, Article 1037

2019

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Fueling Cancer Vaccines to Improve T Cell-Mediated Antitumor Immunity

Frontiers in oncology, 2022-05, Vol.12, p.878377-878377

2022

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The main function of IL-2 is to promote the development of T regulatory cells

Journal of leukocyte biology, 2003-12, Vol.74 (6), p.961-965

Malek, Thomas R.

2003

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Robust IL-2-dependent antitumor immunotherapy requires targeting the high-affinity IL-2R on tumor-specific CD8+ T cells

Journal for immunotherapy of cancer, 2023-06, Vol.11 (6), p.e006611

2023

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Engineering IL-2 for immunotherapy of autoimmunity and cancer

Nature reviews. Immunology, 2022-10, Vol.22 (10), p.614-628

2022

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Promoting Immune Regulation in Type 1 Diabetes Using Low-Dose Interleukin-2

Current Diabetes Reports, 2016-06, Vol.16 (6), p.46-46, Article 46

2016

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Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner

Cell death and differentiation, 2017-02, Vol.24 (2), p.288-299

2017

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Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation

The Journal of clinical investigation, 2010-10, Vol.120 (10), p.3629-3640

2010

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High-dose IL-2/CD25 fusion protein amplifies vaccine-induced CD4+ and CD8+ neoantigen-specific T cells to promote antitumor immunity

Journal for immunotherapy of cancer, 2021-09, Vol.9 (9), p.e002865

2021

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Distinct Activation Signals Determine whether IL-21 Induces B Cell Costimulation, Growth Arrest, or Bim-Dependent Apoptosis

The Journal of immunology (1950), 2004-07, Vol.173 (1), p.657-665

2004

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Regulatory T cells in the treatment of disease

Nature reviews. Drug discovery, 2018-11, Vol.17 (11), p.823-844

2018

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The importance of regulatory T-cell heterogeneity in maintaining self-tolerance

Immunological reviews, 2014-05, Vol.259 (1), p.103-114

2014

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Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes

Diabetes (New York, N.Y.), 2015-06, Vol.64 (6), p.2172-2183

2015

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Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity

The Journal of clinical investigation, 2014-01, Vol.124 (1), p.188-197

2014

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Cytokine Signaling in the Development and Homeostasis of Regulatory T cells

Cold Spring Harbor perspectives in biology, 2018-03, Vol.10 (3), p.a028597

2018

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T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells

Immunological reviews, 2011-05, Vol.241 (1), p.63-76

2011

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Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer

Immunity (Cambridge, Mass.), 2024-03, Vol.57 (3), p.414-428

2024

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A Low Interleukin-2 Receptor Signaling Threshold Supports the Development and Homeostasis of T Regulatory Cells

Immunity (Cambridge, Mass.), 2009-02, Vol.30 (2), p.204-217

2009

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IL-2: Fine-tuning the Germinal Center Reaction

Immunity (Cambridge, Mass.), 2012-05, Vol.36 (5), p.702-704

2012

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IL-2R signaling is essential for functional maturation of regulatory T cells during thymic development

The Journal of immunology (1950), 2013-02, Vol.190 (4), p.1567-1575

2013

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Tolerance, not immunity, crucially depends on IL-2

Nature reviews. Immunology, 2004-09, Vol.4 (9), p.665-674

2004

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Redundant and unique regulation of activated mouse B lymphocytes by IL-4 and IL-21

Journal of leukocyte biology, 2006-12, Vol.80 (6), p.1416-1423

2006

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Non-redundant role for IL-7R signaling for the survival of CD8⁺ memory T cells

European journal of immunology, 2007-11, Vol.37 (11), p.3078-3088

2007

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Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

The biology of interleukin-2

Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells

Fueling Cancer Vaccines to Improve T Cell-Mediated Antitumor Immunity

The main function of IL-2 is to promote the development of T regulatory cells

Robust IL-2-dependent antitumor immunotherapy requires targeting the high-affinity IL-2R on tumor-specific CD8+ T cells

Engineering IL-2 for immunotherapy of autoimmunity and cancer

Promoting Immune Regulation in Type 1 Diabetes Using Low-Dose Interleukin-2

Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner

Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation

High-dose IL-2/CD25 fusion protein amplifies vaccine-induced CD4+ and CD8+ neoantigen-specific T cells to promote antitumor immunity

Distinct Activation Signals Determine whether IL-21 Induces B Cell Costimulation, Growth Arrest, or Bim-Dependent Apoptosis

Regulatory T cells in the treatment of disease

The importance of regulatory T-cell heterogeneity in maintaining self-tolerance

Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes

Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity

Cytokine Signaling in the Development and Homeostasis of Regulatory T cells

T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells

Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer

A Low Interleukin-2 Receptor Signaling Threshold Supports the Development and Homeostasis of T Regulatory Cells

IL-2: Fine-tuning the Germinal Center Reaction

IL-2R signaling is essential for functional maturation of regulatory T cells during thymic development

Tolerance, not immunity, crucially depends on IL-2

Redundant and unique regulation of activated mouse B lymphocytes by IL-4 and IL-21

Non-redundant role for IL-7R signaling for the survival of CD8⁺ memory T cells

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