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Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition

Nature communications, 2021-06, Vol.12 (1), p.3479-3479, Article 3479

2021

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FMN-dependent oligomerization of putative lactate oxidase from Pediococcus acidilactici

PloS one, 2020-02, Vol.15 (2), p.e0223870-e0223870

2020

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The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry

Biochemical journal, 2019-01, Vol.476 (2), p.307-332

2019

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Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules

Journal of medicinal chemistry, 2022-06, Vol.65 (11), p.7532-7560

2022

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Preparation of screening assays for ADP-ribosyl readers and erasers using the GAP-tag as a binding probe

STAR protocols, 2022-03, Vol.3 (1), p.101147-101147, Article 101147

2022

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Evaluation of 3‐ and 4‐Phenoxybenzamides as Selective Inhibitors of the Mono‐ADP‐Ribosyltransferase PARP10

ChemistryOpen (Weinheim), 2021-10, Vol.10 (10), p.939-948

2021

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Inhibitor screening assay for neurexin-LRRTM adhesion protein interaction involved in synaptic maintenance and neurological disorders

Analytical biochemistry, 2019-12, Vol.587, p.113463, Article 113463

2019

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The crystal structure of acidic β-galactosidase from Aspergillus oryzae

International journal of biological macromolecules, 2013-09, Vol.60, p.109-115

2013

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Derivatives of a PARP Inhibitor TIQ-A through the Synthesis of 8-Alkoxythieno[2,3- c ]isoquinolin-5(4 H )-ones

ACS omega, 2020-06, Vol.5 (22), p.13447-13453

2020

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Macrodomain Binding Compound MRS 2578 Inhibits Alphavirus Replication

Antimicrobial agents and chemotherapy, 2021-11, Vol.65 (12), p.e0139821-e0139821

2021

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[1,2,4]Triazolo[3,4‑b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes

Journal of medicinal chemistry, 2023-01, Vol.66 (2), p.1301-1320

2023

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Discovery of 2‑Amide-3-methylester Thiophenes that Target SARS-CoV‑2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target

Journal of medicinal chemistry, 2024-04, Vol.67 (8), p.6519-6536

2024

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Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs

Bioorganic & medicinal chemistry, 2021-12, Vol.52, p.116511-116511, Article 116511

2021

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Oligomerization mediated by the D2 domain of DTX3L is critical for DTX3L‐PARP9 reading function of mono‐ADP‐ribosylated androgen receptor

Protein science, 2024-04, Vol.33 (4), p.e4945-n/a

2024

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4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10

European journal of medicinal chemistry, 2018-08, Vol.156, p.93-102

2018

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Small-Molecule Screening Assay for Mono-ADP-Ribosyltransferases

Methods in molecular biology (Clifton, N.J.), 2018, Vol.1813, p.237

2018

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Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15

European journal of medicinal chemistry, 2022-07, Vol.237, p.114362-114362, Article 114362

2022

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IceBear: an intuitive and versatile web application for research‐data tracking from crystallization experiment to PDB deposition

Acta crystallographica. Section D, Biological crystallography., 2021-02, Vol.77 (2), p.151-163

2021

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Multiple crystal forms of human MacroD2

Acta crystallographica. Section F, Structural biology communications, 2020-10, Vol.76 (10), p.477-482

2020

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A molecular toolbox for ADP-ribosyl binding proteins

Cell reports methods, 2021-12, Vol.1 (8), p.100121-100121, Article 100121

2021

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Adenosine analogs bearing phosphate isosteres as human MDO1 ligands

Bioorganic & medicinal chemistry, 2018-05, Vol.26 (8), p.1588-1597

2018

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Activity-Based Screening Assay for Mono-ADP-Ribosylhydrolases

SLAS discovery, 2021-01, Vol.26 (1), p.67-76

2021

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Development of an Inhibitor Screening Assay for Mono-ADP-Ribosyl Hydrolyzing Macrodomains Using AlphaScreen Technology

SLAS discovery, 2018-03, Vol.23 (3), p.255-263

2018

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Cover Feature: Evaluation of 3‐ and 4‐Phenoxybenzamides as Selective Inhibitors of the Mono‐ADP‐Ribosyltransferase PARP10 (ChemistryOpen 10/2021)

ChemistryOpen (Weinheim), 2021-10, Vol.10 (10), p.929-929

2021

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A Molecular Toolbox for ADP-Ribosyl Binding Proteins

SSRN Electronic Journal

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Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition

FMN-dependent oligomerization of putative lactate oxidase from Pediococcus acidilactici

The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry

Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules

Preparation of screening assays for ADP-ribosyl readers and erasers using the GAP-tag as a binding probe

Evaluation of 3‐ and 4‐Phenoxybenzamides as Selective Inhibitors of the Mono‐ADP‐Ribosyltransferase PARP10

Inhibitor screening assay for neurexin-LRRTM adhesion protein interaction involved in synaptic maintenance and neurological disorders

The crystal structure of acidic β-galactosidase from Aspergillus oryzae

Derivatives of a PARP Inhibitor TIQ-A through the Synthesis of 8-Alkoxythieno[2,3- c ]isoquinolin-5(4 H )-ones

Macrodomain Binding Compound MRS 2578 Inhibits Alphavirus Replication

[1,2,4]Triazolo[3,4‑b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes

Discovery of 2‑Amide-3-methylester Thiophenes that Target SARS-CoV‑2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target

Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs

Oligomerization mediated by the D2 domain of DTX3L is critical for DTX3L‐PARP9 reading function of mono‐ADP‐ribosylated androgen receptor

4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10

Small-Molecule Screening Assay for Mono-ADP-Ribosyltransferases

Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15

IceBear: an intuitive and versatile web application for research‐data tracking from crystallization experiment to PDB deposition

Multiple crystal forms of human MacroD2

A molecular toolbox for ADP-ribosyl binding proteins

Adenosine analogs bearing phosphate isosteres as human MDO1 ligands

Activity-Based Screening Assay for Mono-ADP-Ribosylhydrolases

Development of an Inhibitor Screening Assay for Mono-ADP-Ribosyl Hydrolyzing Macrodomains Using AlphaScreen Technology

Cover Feature: Evaluation of 3‐ and 4‐Phenoxybenzamides as Selective Inhibitors of the Mono‐ADP‐Ribosyltransferase PARP10 (ChemistryOpen 10/2021)

A Molecular Toolbox for ADP-Ribosyl Binding Proteins

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