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Medicinal chemistry of cannabinoids

Clinical pharmacology and therapeutics, 2015-06, Vol.97 (6), p.553-558

2015

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Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity

Molecular psychiatry, 2013-07, Vol.18 (7), p.813-823

2013

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Activation of cannabinoid CB 1 and CB 2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats

British journal of pharmacology, 2009-01, Vol.152 (5), p.765-777

2009

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Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats

British journal of pharmacology, 2007-11, Vol.152 (5), p.765-777

2007

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Impaired neurogenesis by HIV‐1‐Gp120 is rescued by genetic deletion of fatty acid amide hydrolase enzyme

British journal of pharmacology, 2015-10, Vol.172 (19), p.4603-4614

2015

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Reversal of albuminuria by combined AM6545 and perindopril therapy in experimental diabetic nephropathy

British journal of pharmacology, 2018-12, Vol.175 (23), p.4371-4385

2018

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Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells

British journal of pharmacology, 2013-10, Vol.170 (3), p.489-505

2013

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Anandamide Transport Is Independent of Fatty-Acid Amide Hydrolase Activity and Is Blocked by the Hydrolysis-Resistant Inhibitor AM1172

Proceedings of the National Academy of Sciences - PNAS, 2004-06, Vol.101 (23), p.8756-8761

2004

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A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents

British journal of pharmacology, 2010-10, Vol.161 (3), p.629-642

2010

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Activation of peripheral cannabinoid CB 1 and CB 2 receptors suppresses the maintenance of inflammatory nociception: a comparative analysis

British journal of pharmacology, 2009-01, Vol.150 (2), p.153-163

2009

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The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior

Pharmacology, biochemistry and behavior, 2010-11, Vol.97 (1), p.179-184

2010

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Functional Role of High-Affinity Anandamide Transport, as Revealed by Selective Inhibition

Science (American Association for the Advancement of Science), 1997-08, Vol.277 (5329), p.1094-1097

1997

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Cannabinoid CB1 antagonists and dopamine antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior

Psychopharmacologia, 2008-03, Vol.196 (4), p.565-574

2008

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AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner

British journal of pharmacology, 2015-05, Vol.172 (9), p.2406-2418

2015

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Activation of peripheral cannabinoid CB1 and CB2 receptors suppresses the maintenance of inflammatory nociception: a comparative analysis

British journal of pharmacology, 2007-01, Vol.150 (2), p.153-163

2007

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Activation of Cannabinoid CB2 Receptors Suppresses C-Fiber Responses and Windup in Spinal Wide Dynamic Range Neurons in the Absence and Presence of Inflammation

Journal of neurophysiology, 2004-12, Vol.92 (6), p.3562-3574

2004

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Selective activation of cannabinoid CB2 receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation

Neuroscience, 2003-07, Vol.119 (3), p.747-757

2003

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Inverse agonism of cannabinoid CB 1 receptors potentiates LiCl‐induced nausea in the conditioned gaping model in rats

British journal of pharmacology, 2010-09, Vol.161 (2), p.336-349

2010

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In vitro and non‐invasive in vivo effects of the cannabinoid‐1 receptor agonist AM841 on gastrointestinal motor function in the rat

Neurogastroenterology and motility, 2015-12, Vol.27 (12), p.1721-1735

2015

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Chemoenzymatic synthesis of 2-arachidonoylglycerol, an endogenous ligand for cannabinoid receptors

Tetrahedron letters, 2011-03, Vol.52 (11), p.1149-1150

2011

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Endocannabinoids control spasticity in a multiple sclerosis model

The FASEB journal, 2001-02, Vol.15 (2), p.300-302

2001

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The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing

Neuroscience, 2011-10, Vol.193, p.21-33

2011

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Inverse agonism of cannabinoid CB1 receptors potentiates LiCl‐induced nausea in the conditioned gaping model in rats

British journal of pharmacology, 2010-09, Vol.161 (2), p.336-349

2010

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A Nuclear Messenger Links Cannabinoid-1 (CB1) Signalling to Fatty Liver

Journal of hepatology, 2016, Vol.64 (2), p.S679-S680

2016

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Structural Determinants for Recognition and Translocation by the Anandamide Transporter

Proceedings of the National Academy of Sciences - PNAS, 1999-05, Vol.96 (10), p.5802-5807

1999

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Medicinal chemistry of cannabinoids

Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity

Activation of cannabinoid CB 1 and CB 2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats

Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats

Impaired neurogenesis by HIV‐1‐Gp120 is rescued by genetic deletion of fatty acid amide hydrolase enzyme

Reversal of albuminuria by combined AM6545 and perindopril therapy in experimental diabetic nephropathy

Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells

Anandamide Transport Is Independent of Fatty-Acid Amide Hydrolase Activity and Is Blocked by the Hydrolysis-Resistant Inhibitor AM1172

A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents

Activation of peripheral cannabinoid CB 1 and CB 2 receptors suppresses the maintenance of inflammatory nociception: a comparative analysis

The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior

Functional Role of High-Affinity Anandamide Transport, as Revealed by Selective Inhibition

Cannabinoid CB1 antagonists and dopamine antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior

AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner

Activation of peripheral cannabinoid CB1 and CB2 receptors suppresses the maintenance of inflammatory nociception: a comparative analysis

Activation of Cannabinoid CB2 Receptors Suppresses C-Fiber Responses and Windup in Spinal Wide Dynamic Range Neurons in the Absence and Presence of Inflammation

Selective activation of cannabinoid CB2 receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation

Inverse agonism of cannabinoid CB 1 receptors potentiates LiCl‐induced nausea in the conditioned gaping model in rats

In vitro and non‐invasive in vivo effects of the cannabinoid‐1 receptor agonist AM841 on gastrointestinal motor function in the rat

Chemoenzymatic synthesis of 2-arachidonoylglycerol, an endogenous ligand for cannabinoid receptors

Endocannabinoids control spasticity in a multiple sclerosis model

The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing

Inverse agonism of cannabinoid CB1 receptors potentiates LiCl‐induced nausea in the conditioned gaping model in rats

A Nuclear Messenger Links Cannabinoid-1 (CB1) Signalling to Fatty Liver

Structural Determinants for Recognition and Translocation by the Anandamide Transporter

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