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Effect of substrate concentration on reactive metabolite assessment in drug discovery research

Drug metabolism and pharmacokinetics, 2024-04, Vol.55, p.100937, Article 100937

2024

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Species differences between rats and primates (humans and monkeys) in complex cleavage pathways of DS-8500a characterized by 14C-ADME studies in humans and monkeys after administration of two radiolabeled compounds and in vitro studies

Drug metabolism and pharmacokinetics, 2022-08, Vol.45, p.100459-100459, Article 100459

2022

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Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity

Drug metabolism and disposition, 2008-09, Vol.36 (9), p.1770-1779

2008

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In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions

Xenobiotica, 2019-08, Vol.49 (8), p.961-969

2019

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Quantitative Assessment of Reactive Metabolite Formation using 35S-labeled Glutathione

DRUG METABOLISM AND PHARMACOKINETICS, 2009, Vol.24 (1), p.100-107

2009

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Pharmacokinetics of the Multi‐kinase Inhibitor Pexidartinib: Mass Balance and Dose Proportionality

Clinical pharmacology in drug development, 2023-02, Vol.12 (2), p.159-167

2023

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Prediction of in Vivo Potential for Metabolic Activation of Drugs into Chemically Reactive Intermediate: Correlation of in Vitro and in Vivo Generation of Reactive Intermediates and in Vitro Glutathione Conjugate Formation in Rats and Humans

Chemical research in toxicology, 2007-03, Vol.20 (3), p.455-464

2007

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In Vitro Evaluation of The Potential For Drug-Induced Toxicity Based on 35 S-Labeled Glutathione Adduct Formation And Daily Dose

Bioanalysis, 2012-02, Vol.4 (3), p.263-269

2012

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Inhibitory effect of oligosaccharides derived from plant xyloglucan on intestinal glucose absorption in rat

Journal of Nutritional Science and Vitaminology, 1992, Vol.38(4), pp.391-395

1992

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In vitro evaluation of the potential for drug-induced toxicity based on (35)S-labeled glutathione adduct formation and daily dose

Bioanalysis, 2012-02, Vol.4 (3), p.263

2012

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Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study

Scientific reports, 2021-07, Vol.11 (1), p.14990-14990, Article 14990

2021

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Nuclear localization of EGF receptor and its potential new role as a transcription factor

Nature cell biology, 2001-09, Vol.3 (9), p.802-808

2001

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ANCA-associated systemic vasculitis in Japan: clinical features and prognostic changes

Clinical and experimental nephrology, 2012-08, Vol.16 (4), p.580-588

2012

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Effective method for life-style modifications focused on dietary sodium intake in chronic kidney disease: sub-analysis of the FROM-J study

BMC nephrology, 2024-08, Vol.25 (1), p.274-9

2024

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Pharmacologically Induced Thoracic and Abdominal Aortic Aneurysms in Mice

Hypertension (Dallas, Tex. 1979), 2010-05, Vol.55 (5), p.1267-1274

2010

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Optimum conditions for efficient phagocytosis of rifampicin-loaded PLGA microspheres by alveolar macrophages

Journal of controlled release, 2007-05, Vol.119 (1), p.69-76

2007

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Revised Equations for Estimated GFR From Serum Creatinine in Japan

American journal of kidney diseases, 2009-06, Vol.53 (6), p.982-992

2009

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Behaviour modification intervention for patients with chronic kidney disease could provide a mid- to long-term reduction in public health care expenditure: budget impact analysis

Clinical and experimental nephrology, 2022-06, Vol.26 (6), p.601-611

2022

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Delivery of rifampicin–PLGA microspheres into alveolar macrophages is promising for treatment of tuberculosis

Journal of controlled release, 2010-03, Vol.142 (3), p.339-346

2010

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The efficacy and safety of mizoribine for maintenance therapy in patients with myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis: the usefulness of serum mizoribine monitoring

Clinical and experimental nephrology, 2022-11, Vol.26 (11), p.1092-1099

2022

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Pharmacological Stabilization of Intracranial Aneurysms in Mice: A Feasibility Study

Stroke (1970), 2012-09, Vol.43 (9), p.2450-2456

2012

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Cost-Effectiveness of Behavior Modification Intervention for Patients With Chronic Kidney Disease in the FROM-J Study

Journal of renal nutrition, 2021-09, Vol.31 (5), p.484-493

2021

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Sella turcica bridging in subjects with congenitally missing mandibular second premolars

Journal of Osaka Dental University, 2021/10/25, Vol.55(2), pp.213-217

2021

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GFR Estimation Using Standardized Serum Cystatin C in Japan

American journal of kidney diseases, 2013-02, Vol.61 (2), p.197-203

2013

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Effect of substrate concentration on reactive metabolite assessment in drug discovery research

Species differences between rats and primates (humans and monkeys) in complex cleavage pathways of DS-8500a characterized by 14C-ADME studies in humans and monkeys after administration of two radiolabeled compounds and in vitro studies

Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity

In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions

Quantitative Assessment of Reactive Metabolite Formation using 35S-labeled Glutathione

Pharmacokinetics of the Multi‐kinase Inhibitor Pexidartinib: Mass Balance and Dose Proportionality

Prediction of in Vivo Potential for Metabolic Activation of Drugs into Chemically Reactive Intermediate: Correlation of in Vitro and in Vivo Generation of Reactive Intermediates and in Vitro Glutathione Conjugate Formation in Rats and Humans

In Vitro Evaluation of The Potential For Drug-Induced Toxicity Based on 35 S-Labeled Glutathione Adduct Formation And Daily Dose

Inhibitory effect of oligosaccharides derived from plant xyloglucan on intestinal glucose absorption in rat

In vitro evaluation of the potential for drug-induced toxicity based on (35)S-labeled glutathione adduct formation and daily dose

Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study

Nuclear localization of EGF receptor and its potential new role as a transcription factor

ANCA-associated systemic vasculitis in Japan: clinical features and prognostic changes

Effective method for life-style modifications focused on dietary sodium intake in chronic kidney disease: sub-analysis of the FROM-J study

Pharmacologically Induced Thoracic and Abdominal Aortic Aneurysms in Mice

Optimum conditions for efficient phagocytosis of rifampicin-loaded PLGA microspheres by alveolar macrophages

Site-level progression of periodontal disease during a follow-up period

Revised Equations for Estimated GFR From Serum Creatinine in Japan

Behaviour modification intervention for patients with chronic kidney disease could provide a mid- to long-term reduction in public health care expenditure: budget impact analysis

Delivery of rifampicin–PLGA microspheres into alveolar macrophages is promising for treatment of tuberculosis

The efficacy and safety of mizoribine for maintenance therapy in patients with myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis: the usefulness of serum mizoribine monitoring

Pharmacological Stabilization of Intracranial Aneurysms in Mice: A Feasibility Study

Cost-Effectiveness of Behavior Modification Intervention for Patients With Chronic Kidney Disease in the FROM-J Study

Sella turcica bridging in subjects with congenitally missing mandibular second premolars

GFR Estimation Using Standardized Serum Cystatin C in Japan

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