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A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating Mycobacterium tuberculosis

ACS chemical biology, 2012-07, Vol.7 (7), p.1190-1197

2012

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The nuclear receptor LXR is a glucose sensor

Nature, 2007-01, Vol.445 (7124), p.219-223

2007

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Structure-guided combination therapy to potently improve the function of mutant CFTRs

Nature medicine, 2018-11, Vol.24 (11), p.1732-1742

2018

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Dissection of the Insulin-Sensitizing Effect of Liver X Receptor Ligands

Molecular endocrinology (Baltimore, Md.), 2007-12, Vol.21 (12), p.3002-3012

2007

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Development of an Automated, High-Throughput Bactericidal Assay That Measures Cellular Respiration as a Survival Readout for Neisseria meningitidis

Clinical and Vaccine Immunology, 2011-08, Vol.18 (8), p.1252-1260

2011

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Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors

Journal of lipid research, 2002-12, Vol.43 (12), p.2037-2041

2002

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Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation

Proceedings of the National Academy of Sciences - PNAS, 2024-01, Vol.121 (1), p.e2307086120

2024

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A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

Nature communications, 2010-08, Vol.1 (5), p.1-8, Article 57

2010

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Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D)

Bioorganic & medicinal chemistry letters, 2023-11, Vol.96, p.129492-129492, Article 129492

2023

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Phospholipid transfer protein is present in human atherosclerotic lesions and is expressed by macrophages and foam cells

Journal of lipid research, 2003-08, Vol.44 (8), p.1453-1461

2003

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Identification of small-molecule protein-protein interaction inhibitors for NKG2D

Proceedings of the National Academy of Sciences - PNAS, 2023-05, Vol.120 (18), p.e2216342120-e2216342120

2023

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LXR-Dependent Gene Expression Is Important for Macrophage Survival and the Innate Immune Response

Cell, 2004-10, Vol.119 (2), p.299-309

2004

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Control of Cellular Cholesterol Efflux by the Nuclear Oxysterol Receptor LXRα

Proceedings of the National Academy of Sciences - PNAS, 2000-10, Vol.97 (22), p.12097-12102

2000

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Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta

The Journal of biological chemistry, 2002-08, Vol.277 (35), p.31900-31908

2002

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LXRs;: Oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis

Vascular pharmacology, 2002-04, Vol.38 (4), p.249-256

2002

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N-Acylthiadiazolines, a New Class of Liver X Receptor Agonists with Selectivity for LXRβ

Journal of medicinal chemistry, 2007-08, Vol.50 (17), p.4255-4259

2007

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Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling

Cell metabolism, 2006-05, Vol.3 (5), p.367-378

2006

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A Potent Anti-influenza Compound Blocks Fusion through Stabilization of the Prefusion Conformation of the Hemagglutinin Protein

ACS infectious diseases, 2015-02, Vol.1 (2), p.98-109

2015

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A role for the apoptosis inhibitory factor AIM/Spα/Api6 in atherosclerosis development

Cell metabolism, 2005-03, Vol.1 (3), p.201-213

2005

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Regulated Expression of the Apolipoprotein E/C-I/C-IV/C-II Gene Cluster in Murine and Human Macrophages

The Journal of biological chemistry, 2002-08, Vol.277 (35), p.31900-31908

2002

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N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta

Journal of medicinal chemistry, 2007-08, Vol.50 (17), p.4255-4259

2007

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A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development

Cell metabolism, 2005-03, Vol.1 (3), p.201-213

2005

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LXRs

Vascular pharmacology, 2002-04, Vol.38 (4), p.249-256

2002

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LXRs; Oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis: Oxidized lipids as potential mediators of atheriosclerosis

Vascular pharmacology, 2002, Vol.38 (4), p.249-256

2002

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Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRalpha

Proceedings of the National Academy of Sciences - PNAS, 2000-10, Vol.97 (22), p.12097

2000

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A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating Mycobacterium tuberculosis

The nuclear receptor LXR is a glucose sensor

Structure-guided combination therapy to potently improve the function of mutant CFTRs

Dissection of the Insulin-Sensitizing Effect of Liver X Receptor Ligands

Development of an Automated, High-Throughput Bactericidal Assay That Measures Cellular Respiration as a Survival Readout for Neisseria meningitidis

Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors

Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D)

Phospholipid transfer protein is present in human atherosclerotic lesions and is expressed by macrophages and foam cells

Identification of small-molecule protein-protein interaction inhibitors for NKG2D

LXR-Dependent Gene Expression Is Important for Macrophage Survival and the Innate Immune Response

Control of Cellular Cholesterol Efflux by the Nuclear Oxysterol Receptor LXRα

Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta

LXRs;: Oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis

N-Acylthiadiazolines, a New Class of Liver X Receptor Agonists with Selectivity for LXRβ

Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling

A Potent Anti-influenza Compound Blocks Fusion through Stabilization of the Prefusion Conformation of the Hemagglutinin Protein

A role for the apoptosis inhibitory factor AIM/Spα/Api6 in atherosclerosis development

Regulated Expression of the Apolipoprotein E/C-I/C-IV/C-II Gene Cluster in Murine and Human Macrophages

N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta

A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development

LXRs

LXRs; Oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis: Oxidized lipids as potential mediators of atheriosclerosis

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRalpha

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