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Modulation of Peripheral Serotonin Levels by Novel Tryptophan Hydroxylase Inhibitors for the Potential Treatment of Functional Gastrointestinal Disorders

Journal of medicinal chemistry, 2008-07, Vol.51 (13), p.3684-3687

2008

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Mo2021 Lx1606 (Aka LX1032), a Peripheral Inhibitor of Serotonin Synthesis, Alleviates Development of Inflammatory Bowel Disease in a Preclinical Model

Gastroenterology (New York, N.Y. 1943), 2012-05, Vol.142 (5), p.S-722-S-722

2012

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Tu1333 Lx1033, a Second Generation Locally-Acting Serotonin Synthesis Inhibitor Demonstrates Increased Potency and Favorable Safety Profile in Preclinical Studies

Gastroenterology (New York, N.Y. 1943), 2012-05, Vol.142 (5), p.S-805-S-805

2012

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Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.5229-5232

2009

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Photophobia and Phonophobia in Migraineurs Between Attacks

Headache, 1997-09, Vol.37 (8), p.492-495

1997

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907 LX1031, a Novel Locally-Acting Inhibitor of Serotonin (5-HT) Synthesis Significantly Improves Symptoms in Patients With IBS

Gastroenterology (New York, N.Y. 1943), 2010, Vol.138 (5), p.S-129-S-129

2010

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S1053 Serotonin Biomarker Levels Correlate With Clinical Response in Phase 2 Trial of LX1031, a Novel Serotonin Synthesis Inhibitor for Non-Constipating IBS

Gastroenterology (New York, N.Y. 1943), 2010, Vol.138 (5), p.S-168-S-168

2010

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The Wavelength of Light Causing Photophobia in Migraine and Tension-type Headache Between Attacks

Headache, 2000-03, Vol.40 (3), p.194-199

2000

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Genetic deletion of Mst1 alters T cell function and protects against autoimmunity

PloS one, 2014-05, Vol.9 (5), p.e98151-e98151

2014

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Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone Oxime (LX2931) and (1R,2S,3R)-1-(2-(Isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932)

Journal of medicinal chemistry, 2010-12, Vol.53 (24), p.8650-8662

2010

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Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain

The Journal of pharmacology and experimental therapeutics, 2016-09, Vol.358 (3), p.371

2016

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Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of ( E )-1-(4-((1 R ,2 S ,3 R )-1,2,3,4-Tetrahydroxybutyl)-1 H -imidazol-2-yl)ethanone Oxime (LX2931) and (1 R ,2 S ,3 R )-1-(2-(Isoxazol-3-yl)-1 H -imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932)

Journal of medicinal chemistry, 2010-12, Vol.53 (24), p.8650-8662

2010

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Inhibition of Sphingosine-1-Phosphate Lyase for the Treatment of Autoimmune Disorders

Journal of medicinal chemistry, 2009-07, Vol.52 (13), p.3941-3953

2009

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Synthesis and Structure-Activity Relationships of Oxamic Acid and Acetic Acid Derivatives Related to L-Thyronine

Journal of medicinal chemistry, 1995-02, Vol.38 (4), p.695-707

1995

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Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 2. Synthesis and biological activity of 8-(benzenesulfonamido)-7-(3-pyridinyl)octanoic acid and related compounds

Journal of medicinal chemistry, 1992-11, Vol.35 (23), p.4362-4365

1992

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Genetic and Chemical Inhibition of Sphingosine 1-Phosphate Lyase Results in Peripheral Lymphopenia and Alleviates Disease Development in Animal Models of Inflammation and Autoimmunity

Blood, 2007-11, Vol.110 (11), p.2292-2292

2007

Volltextzugriff (PDF)

Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 3. Pyridinylalkyl-substituted 8-[(arylsulfonyl)amino]octanoic acids

Journal of medicinal chemistry, 1992-11, Vol.35 (23), p.4366-4372

1992

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N-aryl cinnamides : A novel class of rigid and highly potent leukotriene B4 receptor antagonists

Bioorganic & medicinal chemistry letters, 1997-01, Vol.7 (7), p.949-954

1997

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Religion and the Media. Edited by Chris Arthur. Cardiff, University of Wales Press, 1993. Pp. xii + 302. No price

Scottish journal of theology, 1996-08, Vol.49 (3), p.389-389

Main, Alan

1996

Volltextzugriff (PDF)

Learning to Care: Christian Reflection on Pastoral Practice. By Michael H. Taylor. London, SPCK, 1983. Pp. 114. £3·95

Scottish journal of theology, 1984-08, Vol.37 (3), p.424-426

Main, Alan

1984

Volltextzugriff (PDF)

N-aryl cinnamides: A novel class of rigid and highly potent leukotriene B 4 receptor antagonists

Bioorganic & medicinal chemistry letters, 1997-04, Vol.7 (7), p.949-954

1997

Volltextzugriff (PDF)

Healey, et al., "Managing Cities: The New Urban Context" (Book Review)

Antipode, 1997, Vol.29 (4), p.456

Main, Alan

1997

Volltextzugriff (PDF)

Religion and the Media. Edited by ArthurChris. Cardiff, University of Wales Press, 1993. Pp. xii + 302. No price

Scottish Journal of Theology, 1996, Vol.49 (3), p.389-389

Main, Alan

1996

Volltextzugriff (PDF)

Religion and the Media

Scottish Journal of Theology, 1996, Vol.49 (3), p.389-389

Main, Alan

1996

Volltextzugriff (PDF)

The origins of John Knox's doctrine of just rebellion

Main, Alan

1963

Volltextzugriff (PDF)

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Modulation of Peripheral Serotonin Levels by Novel Tryptophan Hydroxylase Inhibitors for the Potential Treatment of Functional Gastrointestinal Disorders

Mo2021 Lx1606 (Aka LX1032), a Peripheral Inhibitor of Serotonin Synthesis, Alleviates Development of Inflammatory Bowel Disease in a Preclinical Model

Tu1333 Lx1033, a Second Generation Locally-Acting Serotonin Synthesis Inhibitor Demonstrates Increased Potency and Favorable Safety Profile in Preclinical Studies

Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors

Photophobia and Phonophobia in Migraineurs Between Attacks

907 LX1031, a Novel Locally-Acting Inhibitor of Serotonin (5-HT) Synthesis Significantly Improves Symptoms in Patients With IBS

S1053 Serotonin Biomarker Levels Correlate With Clinical Response in Phase 2 Trial of LX1031, a Novel Serotonin Synthesis Inhibitor for Non-Constipating IBS

The Wavelength of Light Causing Photophobia in Migraine and Tension-type Headache Between Attacks

Genetic deletion of Mst1 alters T cell function and protects against autoimmunity

Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone Oxime (LX2931) and (1R,2S,3R)-1-(2-(Isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932)

Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain

Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of ( E )-1-(4-((1 R ,2 S ,3 R )-1,2,3,4-Tetrahydroxybutyl)-1 H -imidazol-2-yl)ethanone Oxime (LX2931) and (1 R ,2 S ,3 R )-1-(2-(Isoxazol-3-yl)-1 H -imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932)

Inhibition of Sphingosine-1-Phosphate Lyase for the Treatment of Autoimmune Disorders

Synthesis and Structure-Activity Relationships of Oxamic Acid and Acetic Acid Derivatives Related to L-Thyronine

Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 2. Synthesis and biological activity of 8-(benzenesulfonamido)-7-(3-pyridinyl)octanoic acid and related compounds

Genetic and Chemical Inhibition of Sphingosine 1-Phosphate Lyase Results in Peripheral Lymphopenia and Alleviates Disease Development in Animal Models of Inflammation and Autoimmunity

Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 3. Pyridinylalkyl-substituted 8-[(arylsulfonyl)amino]octanoic acids

N-aryl cinnamides : A novel class of rigid and highly potent leukotriene B4 receptor antagonists

Religion and the Media. Edited by Chris Arthur. Cardiff, University of Wales Press, 1993. Pp. xii + 302. No price

Learning to Care: Christian Reflection on Pastoral Practice. By Michael H. Taylor. London, SPCK, 1983. Pp. 114. £3·95

N-aryl cinnamides: A novel class of rigid and highly potent leukotriene B 4 receptor antagonists

Healey, et al., "Managing Cities: The New Urban Context" (Book Review)

Religion and the Media. Edited by ArthurChris. Cardiff, University of Wales Press, 1993. Pp. xii + 302. No price

Religion and the Media

The origins of John Knox's doctrine of just rebellion

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