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N-Heterocyclic Carbene-Amine Pt(II) Complexes, a New Chemical Space for the Development of Platinum-Based Anticancer Drugs

Journal of medicinal chemistry, 2010-03, Vol.53 (5), p.2146-2154

2010

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Variations in the colchicine-binding domain provide insight into the structural switch of tubulin

Proceedings of the National Academy of Sciences - PNAS, 2009-08, Vol.106 (33), p.13775-13779

2009

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Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands

Oncogene, 2005-04, Vol.24 (18), p.2917-2928

2005

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Investigating the Effect of Mono- and Dimeric 360A G-Quadruplex Ligands on Telomere Stability by Single Telomere Length Analysis (STELA)

Molecules (Basel, Switzerland), 2019-02, Vol.24 (3), p.577

2019

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Stabilization of the c-myc gene promoter quadruplex by specific ligands’ inhibitors of telomerase

Biochemical and biophysical research communications, 2004-10, Vol.323 (3), p.802-808

2004

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Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-c]pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone

Journal of medicinal chemistry, 2011-10, Vol.54 (20), p.7206-7219

2011

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Resistance to the Short Term Antiproliferative Activity of the G-quadruplex Ligand 12459 Is Associated with Telomerase Overexpression and Telomere Capping Alteration

The Journal of biological chemistry, 2003-12, Vol.278 (50), p.50554-50562

2003

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Telomerase: a therapeutic target for the third millennium?

Critical reviews in oncology/hematology, 2000-05, Vol.34 (2), p.111-126

2000

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Cooperative 2:1 Binding of a Bisphenothiazine to Duplex DNA

Chembiochem : a European journal of chemical biology, 2008-04, Vol.9 (6), p.849-852

2008

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Natural and pharmacological regulation of telomerase

Nucleic acids research, 2002-02, Vol.30 (4), p.839-865

2002

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Ring-Closing Enyne Metathesis of Terminal Alkynes with Propargylic Hindrance

Journal of organic chemistry, 2015-05, Vol.80 (10), p.5359-5363

2015

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DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase

Nucleic acids research, 2013-04, Vol.41 (6), p.3588-3599

2013

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Preferential binding of a G-quadruplex ligand to human chromosome ends

Nucleic acids research, 2005-01, Vol.33 (13), p.4182-4190

2005

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Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing

Nucleic acids research, 2004-01, Vol.32 (1), p.371-379

2004

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Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death

Cellular and molecular life sciences : CMLS, 2012-02, Vol.69 (4), p.629-640

2012

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Total Synthesis of Herbimycin A

Organic letters, 2007-01, Vol.9 (1), p.145-148

2007

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A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT)

International journal of cancer, 2015-04, Vol.136 (7), p.1546-1558

2015

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Targeting human telomerase for cancer therapeutics

Cytotechnology (Dordrecht), 2004-06, Vol.45 (1-2), p.75-90

2004

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Selective Interaction of Ethidium Derivatives with Quadruplexes: An Equilibrium Dialysis and Electrospray Ionization Mass Spectrometry Analysis

Biochemistry (Easton), 2003-09, Vol.42 (35), p.10361-10371

2003

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ATR contributes to telomere maintenance in human cells

Nucleic acids research, 2010-05, Vol.38 (9), p.2955-2963

2010

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Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes

Nucleic acids research, 2001-03, Vol.29 (5), p.1087-1096

2001

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Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence

Nucleic acids research, 2005-01, Vol.33 (7), p.2192-2203

2005

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1,3-Dipolar cycloaddition route to novel isoxazole-type derivatives related to combretastatin A-4

Tetrahedron letters, 2004-04, Vol.45 (17), p.3359-3362

2004

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Diastereoselective Syntheses of New Analogues of the Farnesyltransferase Inhibitor RPR 130401

Journal of organic chemistry, 2004-10, Vol.69 (21), p.7220-7227

2004

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Synthesis of Oxa-Bridged Analogues of Farnesyltransferase Inhibitor RPR 115135

Journal of organic chemistry, 2001-06, Vol.66 (11), p.3797-3805

2001

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N-Heterocyclic Carbene-Amine Pt(II) Complexes, a New Chemical Space for the Development of Platinum-Based Anticancer Drugs

Variations in the colchicine-binding domain provide insight into the structural switch of tubulin

Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands

Investigating the Effect of Mono- and Dimeric 360A G-Quadruplex Ligands on Telomere Stability by Single Telomere Length Analysis (STELA)

Stabilization of the c-myc gene promoter quadruplex by specific ligands’ inhibitors of telomerase

Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-c]pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone

Resistance to the Short Term Antiproliferative Activity of the G-quadruplex Ligand 12459 Is Associated with Telomerase Overexpression and Telomere Capping Alteration

Telomerase: a therapeutic target for the third millennium?

Cooperative 2:1 Binding of a Bisphenothiazine to Duplex DNA

Natural and pharmacological regulation of telomerase

Ring-Closing Enyne Metathesis of Terminal Alkynes with Propargylic Hindrance

DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase

Preferential binding of a G-quadruplex ligand to human chromosome ends

Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing

Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death

Total Synthesis of Herbimycin A

A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT)

Targeting human telomerase for cancer therapeutics

Selective Interaction of Ethidium Derivatives with Quadruplexes: An Equilibrium Dialysis and Electrospray Ionization Mass Spectrometry Analysis

ATR contributes to telomere maintenance in human cells

Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes

Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence

1,3-Dipolar cycloaddition route to novel isoxazole-type derivatives related to combretastatin A-4

Diastereoselective Syntheses of New Analogues of the Farnesyltransferase Inhibitor RPR 130401

Synthesis of Oxa-Bridged Analogues of Farnesyltransferase Inhibitor RPR 115135

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