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Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making

Environmental health perspectives, 2015-12, Vol.123 (12), p.1232-1240

2015

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A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme

Toxicology in vitro, 2018-08, Vol.50, p.137-146

2018

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The future trajectory of adverse outcome pathways: a commentary

Archives of toxicology, 2018-04, Vol.92 (4), p.1657-1661

2018

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Identification and semi-quantification of protein allergens in complex mixtures using proteomic and AllerCatPro 2.0 bioinformatic analyses: a proof-of-concept investigation

Journal of immunotoxicology, 2024-12, Vol.21 (1), p.2305452-2305452

2024

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Multi-Detector Characterization of Grape Seed Extract to Enable in silico Safety Assessment

Frontiers in chemistry, 2018-08, Vol.6, p.334-334

2018

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Industry strategy and approaches for botanical safety evaluation

Toxicology letters, 2017-10, Vol.280, p.S41-S41

Mahony, Catherine

2017

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P169 - Pyrrolizidine alkaloid DNA adduct formation and the interplay between uptake, metabolism, and efflux in rat sandwich cultured hepatocytes

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S74-S74

2020

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Application of AllerCatPro 2.0 for protein safety assessments of consumer products

Frontiers in allergy, 2023-07, Vol.4, p.1209495

2023

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In vitro assessment of the relative toxicity of a series of pyrrolizidine alkaloids: Taking account of metabolic activation and toxicokinetics

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S54-S54

2019

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Case studies to test: A framework for using structural, reactivity, metabolic and physicochemical similarity to evaluate the suitability of analogs for SAR-based toxicological assessments

Regulatory toxicology and pharmacology, 2011-06, Vol.60 (1), p.120-135

2011

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Relative potency of fifteen pyrrolizidine alkaloids to induce DNA damage as measured by micronucleus induction in HepaRG human liver cells

Food and chemical toxicology, 2018-11, Vol.121, p.72-81

2018

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Evaluation of mixture toxicity literature and chemical space: a data centric approach

Environmental science--processes & impacts, 2023-11, Vol.25 (11), p.1752-1758

2023

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Cosmetics Europe systemic toxicity case studies

Toxicology letters, 2017-10, Vol.280, p.S319-S319

2017

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Building confidence in non-animal methods: Practical examples of collaboration between regulators, researchers and industry

Computational toxicology, 2019-05, Vol.10, p.78-80

Mahony, Catherine

2019

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The in vitro genotoxicity potency of mixtures of pyrrolizidine alkaloids can be explained by dose addition of the individual mixture components

Environmental and molecular mutagenesis, 2022-12, Vol.63 (8-9), p.400-407

2022

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Assessing Safety Without Animal Testing: The Road Ahead

Toxicological sciences, 2022-05, Vol.187 (2), p.214-218

2022

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A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth

Current biology, 1995-07, Vol.5 (7), p.797-806

1995

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Pyrrolizidine alkaloids in food and phytomedicine: Occurrence, exposure, toxicity, mechanisms, and risk assessment - A review

Food and chemical toxicology, 2020-02, Vol.136, p.111107, Article 111107

2020

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Assessing the genotoxicity and carcinogenicity of 2-chloroethanol through structure activity relationships and in vitro testing approaches

Food and chemical toxicology, 2022-10, Vol.168, p.113290-113290, Article 113290

2022

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A 10-step framework for use of read-across (RAX) in next generation risk assessment (NGRA) for cosmetics safety assessment

Regulatory toxicology and pharmacology, 2022-03, Vol.129, p.105094-105094, Article 105094

2022

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In vitro pharmacologic profiling aids systemic toxicity assessment of chemicals

Toxicology and applied pharmacology, 2024-10, p.117131, Article 117131

2024

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A Tiered Approach for the Evaluation of the Safety of Botanicals Used as Dietary Supplements: An Industry Strategy

Clinical pharmacology and therapeutics, 2018-09, Vol.104 (3), p.446-457

2018

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Support for Regulatory Assessment of Percutaneous Absorption of Retronecine-type Pyrrolizidine Alkaloids through Human Skin

Planta medica, 2022-02, Vol.88 (2), p.144-151

2022

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Threshold of toxicological concern (TTC) for botanicals - Concentration data analysis of potentially genotoxic constituents to substantiate and extend the TTC approach to botanicals

Food and chemical toxicology, 2020-04, Vol.138, p.111182, Article 111182

2020

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Intrinsic relative potency of a series of pyrrolizidine alkaloids characterized by rate and extent of metabolism

Food and chemical toxicology, 2019-09, Vol.131, p.110523, Article 110523

2019

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Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making

A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme

The future trajectory of adverse outcome pathways: a commentary

Identification and semi-quantification of protein allergens in complex mixtures using proteomic and AllerCatPro 2.0 bioinformatic analyses: a proof-of-concept investigation

Multi-Detector Characterization of Grape Seed Extract to Enable in silico Safety Assessment

Industry strategy and approaches for botanical safety evaluation

P169 - Pyrrolizidine alkaloid DNA adduct formation and the interplay between uptake, metabolism, and efflux in rat sandwich cultured hepatocytes

Application of AllerCatPro 2.0 for protein safety assessments of consumer products

In vitro assessment of the relative toxicity of a series of pyrrolizidine alkaloids: Taking account of metabolic activation and toxicokinetics

Case studies to test: A framework for using structural, reactivity, metabolic and physicochemical similarity to evaluate the suitability of analogs for SAR-based toxicological assessments

Relative potency of fifteen pyrrolizidine alkaloids to induce DNA damage as measured by micronucleus induction in HepaRG human liver cells

Evaluation of mixture toxicity literature and chemical space: a data centric approach

Cosmetics Europe systemic toxicity case studies

Building confidence in non-animal methods: Practical examples of collaboration between regulators, researchers and industry

The in vitro genotoxicity potency of mixtures of pyrrolizidine alkaloids can be explained by dose addition of the individual mixture components

Assessing Safety Without Animal Testing: The Road Ahead

A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth

Pyrrolizidine alkaloids in food and phytomedicine: Occurrence, exposure, toxicity, mechanisms, and risk assessment - A review

Assessing the genotoxicity and carcinogenicity of 2-chloroethanol through structure activity relationships and in vitro testing approaches

A 10-step framework for use of read-across (RAX) in next generation risk assessment (NGRA) for cosmetics safety assessment

In vitro pharmacologic profiling aids systemic toxicity assessment of chemicals

A Tiered Approach for the Evaluation of the Safety of Botanicals Used as Dietary Supplements: An Industry Strategy

Support for Regulatory Assessment of Percutaneous Absorption of Retronecine-type Pyrrolizidine Alkaloids through Human Skin

Threshold of toxicological concern (TTC) for botanicals - Concentration data analysis of potentially genotoxic constituents to substantiate and extend the TTC approach to botanicals

Intrinsic relative potency of a series of pyrrolizidine alkaloids characterized by rate and extent of metabolism

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