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Concepts to Target MYC in Pancreatic Cancer

Molecular cancer therapeutics, 2016-08, Vol.15 (8), p.1792-1798

2016

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Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance

Scientific reports, 2018-07, Vol.8 (1), p.10039-17, Article 10039

2018

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Novel Chimeric Histone Deacetylase Inhibitors: A Series of Lapatinib Hybrides as Potent Inhibitors of Epidermal Growth Factor Receptor (EGFR), Human Epidermal Growth Factor Receptor 2 (HER2), and Histone Deacetylase Activity

Journal of medicinal chemistry, 2010-12, Vol.53 (24), p.8546-8555

2010

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Inhibitors of the tyrosine kinases FMS-like tyrosine kinase-3 and WEE1 induce apoptosis and DNA damage synergistically in acute myeloid leukemia cells

Biomedicine & pharmacotherapy, 2024-08, Vol.177, p.117076, Article 117076

2024

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Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3

Archives of toxicology, 2022-01, Vol.96 (1), p.177-193

2022

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Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation

Oncotarget, 2017-04, Vol.8 (16), p.26613-26624

2017

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Chimerically designed HDAC- and tyrosine kinase inhibitors. A series of erlotinib hybrids as dual-selective inhibitors of EGFR, HER2 and histone deacetylases

MedChemComm, 2012-07, Vol.3 (7), p.829

2012

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Drugging the HDAC6–HSP90 interplay in malignant cells

Trends in pharmacological sciences (Regular ed.), 2014-10, Vol.35 (10), p.501-509

2014

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A Single Amino Acid Exchange Inverts Susceptibility of Related Receptor Tyrosine Kinases for the ATP Site Inhibitor STI-571

The Journal of biological chemistry, 2003-02, Vol.278 (7), p.5148-5155

2003

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Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[ b]furan-2-yl)methanones

Bioorganic & medicinal chemistry, 2007-03, Vol.15 (5), p.2187-2197

2007

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Generation and Assessment of Fusions Between HDACi and TKi

Methods in molecular biology (Clifton, N.J.), 2017, Vol.1510, p.405

2017

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Design and biological evaluation of tetrahydro-β-carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors

European journal of medicinal chemistry, 2018-05, Vol.152, p.329-357

2018

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Biological and structural investigation of tetrahydro-β-carboline-based selective HDAC6 inhibitors with improved stability

European journal of medicinal chemistry, 2024-10, Vol.276, p.116676, Article 116676

2024

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Histone deacetylase inhibitors modulate hormesis in leukemic cells with mutant FMS-like tyrosine kinase-3

Leukemia, 2023-11, Vol.37 (11), p.2319-2323

2023

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Enantioselective synthesis and biological investigation of tetrahydro‐β‐carboline‐based HDAC6 inhibitors with improved solubility

Archiv der Pharmazie (Weinheim), 2019-06, Vol.352 (6), p.e1900026-n/a

2019

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How to Distinguish Between the Activity of HDAC1-3 and HDAC6 with Western Blot

Methods in molecular biology (Clifton, N.J.), 2017, Vol.1510, p.355

2017

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Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition

Oncogene, 2022-09, Vol.41 (40), p.4560-4572

2022

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Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors

Journal of medicinal chemistry, 2018-04, Vol.61 (8), p.3454-3477

2018

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Identification of a highly efficient dual type I/II FMS-like tyrosine kinase inhibitor that disrupts the growth of leukemic cells

Cell chemical biology, 2022-03, Vol.29 (3), p.398-411.e4

2022

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HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3

Cellular signalling, 2017-11, Vol.39, p.9-17

2017

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The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity

Biochemical journal, 2004-08, Vol.382 (Pt 1), p.261-268

2004

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Class I histone deacetylases regulate p53/NF-κB crosstalk in cancer cells

Cellular signalling, 2017-01, Vol.29, p.218-225

2017

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A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer

Bioorganic chemistry, 2022-02, Vol.119, p.105505, Article 105505

2022

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A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia

European journal of medicinal chemistry, 2020-05, Vol.193, p.112232, Article 112232

2020

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Design of Chimeric Histone Deacetylase- and Tyrosine Kinase-Inhibitors: A Series of Imatinib Hybrides as Potent Inhibitors of Wild-Type and Mutant BCR-ABL, PDGF-Rβ, and Histone Deacetylases

Journal of medicinal chemistry, 2009-04, Vol.52 (8), p.2265-2279

2009

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Concepts to Target MYC in Pancreatic Cancer

Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance

Novel Chimeric Histone Deacetylase Inhibitors: A Series of Lapatinib Hybrides as Potent Inhibitors of Epidermal Growth Factor Receptor (EGFR), Human Epidermal Growth Factor Receptor 2 (HER2), and Histone Deacetylase Activity

Inhibitors of the tyrosine kinases FMS-like tyrosine kinase-3 and WEE1 induce apoptosis and DNA damage synergistically in acute myeloid leukemia cells

Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3

Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation

Chimerically designed HDAC- and tyrosine kinase inhibitors. A series of erlotinib hybrids as dual-selective inhibitors of EGFR, HER2 and histone deacetylases

Drugging the HDAC6–HSP90 interplay in malignant cells

A Single Amino Acid Exchange Inverts Susceptibility of Related Receptor Tyrosine Kinases for the ATP Site Inhibitor STI-571

Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[ b]furan-2-yl)methanones

Generation and Assessment of Fusions Between HDACi and TKi

Design and biological evaluation of tetrahydro-β-carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors

Biological and structural investigation of tetrahydro-β-carboline-based selective HDAC6 inhibitors with improved stability

Histone deacetylase inhibitors modulate hormesis in leukemic cells with mutant FMS-like tyrosine kinase-3

Enantioselective synthesis and biological investigation of tetrahydro‐β‐carboline‐based HDAC6 inhibitors with improved solubility

How to Distinguish Between the Activity of HDAC1-3 and HDAC6 with Western Blot

Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition

Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors

Identification of a highly efficient dual type I/II FMS-like tyrosine kinase inhibitor that disrupts the growth of leukemic cells

HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3

The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity

Class I histone deacetylases regulate p53/NF-κB crosstalk in cancer cells

A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer

A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia

Design of Chimeric Histone Deacetylase- and Tyrosine Kinase-Inhibitors: A Series of Imatinib Hybrides as Potent Inhibitors of Wild-Type and Mutant BCR-ABL, PDGF-Rβ, and Histone Deacetylases

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