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European Respiratory Society statement: diagnosis and treatment of pulmonary disease in α1-antitrypsin deficiency

The European respiratory journal, 2017-11, Vol.50 (5), p.1700610-1700610

2017

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Alpha1‐antitrypsin binds hemin and prevents oxidative activation of human neutrophils: putative pathophysiological significance

Journal of leukocyte biology, 2017-10, Vol.102 (4), p.1127-1141

2017

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α1-Antitrypsin deficiency: count me in please

The European respiratory journal, 2017-01, Vol.49 (1), p.1601941-1601941

2017

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α1-Antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy

The Journal of clinical investigation, 2002-12, Vol.110 (11), p.1585-1590

2002

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Anti-inflammatory and immunomodulatory properties of α1-antitrypsin without inhibition of elastase

Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (37), p.15007-15012

2013

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Six key topics informal carers of patients with breathlessness in advanced disease want to learn about and why: MRC phase I study to inform an educational intervention

PloS one, 2017-05, Vol.12 (5), p.e0177081-e0177081

2017

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Trends of testing for and diagnosis of α1-antitrypsin deficiency in the UK: more testing is needed

The European respiratory journal, 2018-07, Vol.52 (1), p.1800360-1800360

2018

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α-Linoleic Acid Enhances the Capacity of α1-Antitrypsin to Inhibit Lipopolysaccharide-Induced IL-1β in Human Blood Neutrophils

Molecular medicine (Cambridge, Mass.), 2016-07, Vol.22 (1), p.680-693

2016

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Emphysema

Ravi Mahadeva

2012

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Living with COPD: the struggle for breath and for lung volume reduction therapies

ERJ open research, 2018-04, Vol.4 (2), p.5

2018

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Oxidized α1-antitrypsin stimulates the release of monocyte chemotactic protein-1 from lung epithelial cells: potential role in emphysema

American journal of physiology. Lung cellular and molecular physiology, 2009-08, Vol.297 (2), p.L388-L400

2009

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Relationship of CT densitometry to lung physiological parameters and health status in alpha-1 antitrypsin deficiency: initial report of a centralised database of the NIHR rare diseases translational research collaborative

BMJ open, 2020-06, Vol.10 (6), p.e036045-e036045

2020

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Do patients and carers agree on symptom burden in advanced COPD?

International journal of chronic obstructive pulmonary disease, 2018-01, Vol.13, p.969-977

2018

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Early respiratory diagnosis: benefits of enhanced lung function assessment

BMJ open respiratory research, 2021-07, Vol.8 (1), p.e001012

2021

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Cholesterol rich lipid raft microdomains are gateway for acute phase protein, SERPINA1

The international journal of biochemistry & cell biology, 2010-09, Vol.42 (9), p.1562-1570

2010

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Clinicians’ views of educational interventions for carers of patients with breathlessness due to advanced disease: findings from an online survey

Journal of pain and symptom management, 2017-02, Vol.53 (2), p.265-271

2017

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Acute-phase protein α1-antitrypsin inhibits neutrophil calpain I and induces random migration

Molecular medicine (Cambridge, Mass.), 2011-09, Vol.17 (9-10), p.865-874

2011

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Lung function improvements in emphysema following pneumonia

Respiratory medicine case reports, 2019-01, Vol.26, p.1-5

2019

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Automated measurement of pulmonary emphysema and small airway remodeling in cigarette smoke-exposed mice

Journal of visualized experiments, 2015-01 (95), p.52236-52236

2015

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Sirolimus-Induced Pulmonary Hypersensitivity Associated With a CD4 T-Cell Infiltrate

Chest, 2006-06, Vol.129 (6), p.1718-1721

2006

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The role of a multidisciplinary severe chronic obstructive pulmonary disease hyperinflation service in patient selection for lung volume reduction

Journal of thoracic disease, 2018-10, Vol.10 (Suppl 27), p.S3335-S3343

2018

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Unravelling the risk of (intermediate) antitrypsin deficiency

Thorax, 2021-03, Vol.76 (3), p.214-215

2021

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Mutant Neuroserpin (S49P) That Causes Familial Encephalopathy with Neuroserpin Inclusion Bodies Is a Poor Proteinase Inhibitor and Readily Forms Polymers in Vitro

The Journal of biological chemistry, 2002-05, Vol.277 (19), p.17367-17373

2002

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Cellular Consequences of Z Alpha-1 Antitrypsin Accumulation and Prospects for Therapy

European medical journal. Hepatology, 2013-12, Vol.1 (1), p.44-51

2013

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Oxidation of Z α 1 -Antitrypsin by Cigarette Smoke Induces Polymerization: A Novel Mechanism of Early-Onset Emphysema

American journal of respiratory cell and molecular biology, 2011-08, Vol.45 (2), p.261-269

2011

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European Respiratory Society statement: diagnosis and treatment of pulmonary disease in α1-antitrypsin deficiency

Alpha1‐antitrypsin binds hemin and prevents oxidative activation of human neutrophils: putative pathophysiological significance

α1-Antitrypsin deficiency: count me in please

α1-Antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy

Anti-inflammatory and immunomodulatory properties of α1-antitrypsin without inhibition of elastase

Six key topics informal carers of patients with breathlessness in advanced disease want to learn about and why: MRC phase I study to inform an educational intervention

Trends of testing for and diagnosis of α1-antitrypsin deficiency in the UK: more testing is needed

α-Linoleic Acid Enhances the Capacity of α1-Antitrypsin to Inhibit Lipopolysaccharide-Induced IL-1β in Human Blood Neutrophils

Emphysema

Living with COPD: the struggle for breath and for lung volume reduction therapies

Oxidized α1-antitrypsin stimulates the release of monocyte chemotactic protein-1 from lung epithelial cells: potential role in emphysema

Relationship of CT densitometry to lung physiological parameters and health status in alpha-1 antitrypsin deficiency: initial report of a centralised database of the NIHR rare diseases translational research collaborative

Do patients and carers agree on symptom burden in advanced COPD?

Early respiratory diagnosis: benefits of enhanced lung function assessment

Cholesterol rich lipid raft microdomains are gateway for acute phase protein, SERPINA1

Clinicians’ views of educational interventions for carers of patients with breathlessness due to advanced disease: findings from an online survey

Acute-phase protein α1-antitrypsin inhibits neutrophil calpain I and induces random migration

Lung function improvements in emphysema following pneumonia

Automated measurement of pulmonary emphysema and small airway remodeling in cigarette smoke-exposed mice

Sirolimus-Induced Pulmonary Hypersensitivity Associated With a CD4 T-Cell Infiltrate

The role of a multidisciplinary severe chronic obstructive pulmonary disease hyperinflation service in patient selection for lung volume reduction

Unravelling the risk of (intermediate) antitrypsin deficiency

Mutant Neuroserpin (S49P) That Causes Familial Encephalopathy with Neuroserpin Inclusion Bodies Is a Poor Proteinase Inhibitor and Readily Forms Polymers in Vitro

Cellular Consequences of Z Alpha-1 Antitrypsin Accumulation and Prospects for Therapy

Oxidation of Z α 1 -Antitrypsin by Cigarette Smoke Induces Polymerization: A Novel Mechanism of Early-Onset Emphysema

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