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Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins

Science (American Association for the Advancement of Science), 1999-06, Vol.284 (5420), p.1664-1666

1999

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Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

The Journal of biological chemistry, 1998-07, Vol.273 (29), p.18623-18632

1998

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Inhibition of Mitogen-Activated Protein Kinase Kinase Blocks T Cell Proliferation But Does Not Induce or Prevent Anergy

The Journal of immunology (1950), 1998-05, Vol.160 (9), p.4175-4181

1998

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Design, Synthesis, and Structure−Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor α Release in Vitro and in Vivo

Journal of medicinal chemistry, 2001-08, Vol.44 (16), p.2636-2660

2001

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Cloning and Characterization of ADAMTS11 , an Aggrecanase from the ADAMTS Family

The Journal of biological chemistry, 1999-08, Vol.274 (33), p.23443-23450

1999

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Discovery of Macrocyclic Hydroxamic Acids Containing Biphenylmethyl Derivatives at P1‘, a Series of Selective TNF-α Converting Enzyme Inhibitors with Potent Cellular Activity in the Inhibition of TNF-α Release

Journal of medicinal chemistry, 2001-10, Vol.44 (21), p.3351-3354

2001

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The Immunosuppressive Metabolite of Leflunomide Is a Potent Inhibitor of Human Dihydroorotate Dehydrogenase

Biochemistry (Easton), 1996-01, Vol.35 (4), p.1270-1273

1996

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MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (20), p.2839-2844

1998

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Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors

Journal of medicinal chemistry, 2001-10, Vol.44 (21), p.3347-3350

2001

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Preclinical characterization of WAY‐211612: a dual 5‐HT uptake inhibitor and 5‐HT 1A receptor antagonist and potential novel antidepressant

British journal of pharmacology, 2009-05, Vol.157 (2), p.307-319

2009

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Preclinical characterization of WAY‐211612: a dual 5‐HT uptake inhibitor and 5‐HT1A receptor antagonist and potential novel antidepressant

British journal of pharmacology, 2009-05, Vol.157 (2), p.307-319

2009

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Aggrecan Protects Cartilage Collagen from Proteolytic Cleavage

The Journal of biological chemistry, 2003-11, Vol.278 (46), p.45539-45545

2003

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Inhibition of MAP Kinase Kinase (MEK) Results in an Anti-inflammatory Response in Vivo

Biochemical and biophysical research communications, 2000-02, Vol.268 (2), p.647-651

2000

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Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by 15 alpha-fluorolanost-7-en-3 beta-ol. A mechanism-based inhibitor of cholesterol biosynthesis

The Journal of biological chemistry, 1993-10, Vol.268 (30), p.22591-22599

1993

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Aggrecanase: A Target for the Design of Inhibitors of Cartilage Degradation

Annals of the New York Academy of Sciences, 1999-06, Vol.878 (1), p.92-107

1999

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Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases

Bioorganic & medicinal chemistry letters, 1998-04, Vol.8 (7), p.837-842

1998

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Inhibition of MAP Kinase Kinase Prevents Cytokine and Prostaglandin E2 Production in Lipopolysaccharide-Stimulated Monocytes

The Journal of immunology (1950), 1998-11, Vol.161 (10), p.5681-5686

1998

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Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents

Bioorganic & medicinal chemistry letters, 1998-07, Vol.8 (13), p.1745-1750

1998

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Lanosterol 14 alpha-methyl demethylase. Isolation and characterization of the third metabolically generated oxidative demethylation intermediate

The Journal of biological chemistry, 1991-04, Vol.266 (10), p.6124-6132

1991

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Terphenyl cyclooxygenase-2 (COX-2) inhibitors: Optimization of the central ring and o-biphenyl analogs

Bioorganic & medicinal chemistry letters, 1999-04, Vol.9 (7), p.919-924

1999

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Total synthesis of ionophore antibiotic X-14547A

Journal of organic chemistry, 1985-05, Vol.50 (9), p.1440-1456

1985

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Structure-activity relationships (SAR) of some tetracyclic heterocycles related to the immunosuppressive agent brequinar sodium

Bioorganic & medicinal chemistry letters, 1998-02, Vol.8 (3), p.307-312

1998

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Discovery and Optimization of p38 Inhibitors via Computer-Assisted Drug Design

Journal of medicinal chemistry, 2007-08, Vol.50 (17), p.4016-4026

2007

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Microsomal enzymes of cholesterol biosynthesis from lanosterol. Solubilization and purification of steroid 8-isomerase

The Journal of biological chemistry, 1986-05, Vol.261 (14), p.6470-6477

1986

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Amide surrogates of matrix metalloproteinase inhibitors: Urea and sulfonamide mimics

Bioorganic & medicinal chemistry letters, 1997-09, Vol.7 (18), p.2331-2336

1997

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Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

Inhibition of Mitogen-Activated Protein Kinase Kinase Blocks T Cell Proliferation But Does Not Induce or Prevent Anergy

Design, Synthesis, and Structure−Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor α Release in Vitro and in Vivo

Cloning and Characterization of ADAMTS11 , an Aggrecanase from the ADAMTS Family

Discovery of Macrocyclic Hydroxamic Acids Containing Biphenylmethyl Derivatives at P1‘, a Series of Selective TNF-α Converting Enzyme Inhibitors with Potent Cellular Activity in the Inhibition of TNF-α Release

The Immunosuppressive Metabolite of Leflunomide Is a Potent Inhibitor of Human Dihydroorotate Dehydrogenase

MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products

Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors

Preclinical characterization of WAY‐211612: a dual 5‐HT uptake inhibitor and 5‐HT 1A receptor antagonist and potential novel antidepressant

Preclinical characterization of WAY‐211612: a dual 5‐HT uptake inhibitor and 5‐HT1A receptor antagonist and potential novel antidepressant

Aggrecan Protects Cartilage Collagen from Proteolytic Cleavage

Inhibition of MAP Kinase Kinase (MEK) Results in an Anti-inflammatory Response in Vivo

Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by 15 alpha-fluorolanost-7-en-3 beta-ol. A mechanism-based inhibitor of cholesterol biosynthesis

Aggrecanase: A Target for the Design of Inhibitors of Cartilage Degradation

Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases

Inhibition of MAP Kinase Kinase Prevents Cytokine and Prostaglandin E2 Production in Lipopolysaccharide-Stimulated Monocytes

Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents

Lanosterol 14 alpha-methyl demethylase. Isolation and characterization of the third metabolically generated oxidative demethylation intermediate

Terphenyl cyclooxygenase-2 (COX-2) inhibitors: Optimization of the central ring and o-biphenyl analogs

Total synthesis of ionophore antibiotic X-14547A

Structure-activity relationships (SAR) of some tetracyclic heterocycles related to the immunosuppressive agent brequinar sodium

Discovery and Optimization of p38 Inhibitors via Computer-Assisted Drug Design

Microsomal enzymes of cholesterol biosynthesis from lanosterol. Solubilization and purification of steroid 8-isomerase

Amide surrogates of matrix metalloproteinase inhibitors: Urea and sulfonamide mimics

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