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Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Journal of medicinal chemistry, 2005-07, Vol.48 (15), p.5025-5037

2005

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Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP)

Bioorganic & medicinal chemistry letters, 2007-06, Vol.17 (12), p.3511-3515

2007

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A Novel Series of Highly Potent Benzimidazole-Based Microsomal Triglyceride Transfer Protein Inhibitors

Journal of medicinal chemistry, 2001-03, Vol.44 (6), p.851-856

2001

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Synthesis of Novel Potent Dipeptidyl Peptidase IV Inhibitors with Enhanced Chemical Stability: Interplay between the N-Terminal Amino Acid Alkyl Side Chain and the Cyclopropyl Group of α-Aminoacyl-l-cis-4,5-methanoprolinenitrile-Based Inhibitors

Journal of medicinal chemistry, 2004-05, Vol.47 (10), p.2587-2598

2004

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Palladium-Catalyzed Microwave-Assisted Amination of 1-Bromonaphthalenes and 5- and 8-Bromoquinolines

Organic letters, 2003-03, Vol.5 (6), p.897-900

2003

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Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry, 2007-12, Vol.17 (23), p.6476-6480

2007

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Regioselectivity and diastereoselectivity in free-radical macrocyclization

Journal of the American Chemical Society, 1989-10, Vol.111 (21), p.8309-8310

1989

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Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry letters, 2005-09, Vol.15 (18), p.3992-3995

2005

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NMR Structure of a Potent Small Molecule Inhibitor Bound to Human Keratinocyte Fatty Acid-Binding Protein

Journal of medicinal chemistry, 2006-08, Vol.49 (16), p.5013-5017

2006

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Seco-prolinenitrile inhibitors of dipeptidyl peptidase IV define minimal pharmacophore requirements at P1

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (6), p.1731-1734

2006

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Application of robotics to steady state enzyme kinetics: analysis of tight-binding inhibitors of dipeptidyl peptidase IV

Analytical biochemistry, 2003-10, Vol.321 (2), p.157-166

2003

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Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (7), p.1337-1340

2003

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Orally Active Squalene Synthase Inhibitors: Bis((acyloxy)alkyl) Prodrugs of the α-Phosphonosulfonic Acid Moiety

Journal of medicinal chemistry, 1996-02, Vol.39 (3), p.661-664

1996

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α-Phosphonosulfonic Acids: Potent and Selective Inhibitors of Squalene Synthase

Journal of medicinal chemistry, 1996-02, Vol.39 (3), p.657-660

1996

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1,1-Bisphosphonate Squalene Synthase Inhibitors: Interplay Between the Isoprenoid Subunit and the Diphosphate Surrogate

Journal of medicinal chemistry, 1995-07, Vol.38 (14), p.2596-2605

1995

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An MTP Inhibitor that Normalizes Atherogenic Lipoprotein Levels in WHHL Rabbits

Science (American Association for the Advancement of Science), 1998-10, Vol.282 (5389), p.751-754

1998

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Enantioselective Synthesis of α-Phosphono Sulfonate Squalene Synthase Inhibitors: Chiral Recognition in the Interactions of an α-Phosphono Sulfonate Inhibitor with Squalene Synthase

Journal of the American Chemical Society, 1996-11, Vol.118 (46), p.11668-11669

1996

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Free-radical macrocyclization-transannular cyclization

Journal of the American Chemical Society, 1988-05, Vol.110 (11), p.3554-3560

1988

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Free radical macrocyclization

Journal of the American Chemical Society, 1986-05, Vol.108 (10), p.2787-2788

1986

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Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo

The Journal of biological chemistry, 1993-11, Vol.268 (33), p.24832-24837

1993

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An Efficient Palladium-Catalyzed Synthesis of γ,δ-Alkenyl-1,1-Bisphosphonates

Synlett, 1993-12, Vol.1993 (12), p.933-934

1993

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Palladium-Catalyzed Microwave-Assisted Amination of 1-Bromonaphthalenes and 5- and 8-Bromoquinolines

ChemInform, 2003-09, Vol.34 (35), p.no-no

2003

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A unified approach to prostanoid and corticosteroid synthons

Tetrahedron letters, 1984, Vol.25 (1), p.19-22

1984

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Zika Virus Infection during Pregnancy and Effects on Early Childhood Development, French Polynesia, 2013-2016

Emerging infectious diseases, 2018-10, Vol.24 (10), p.1850-1858

2018

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Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP)

A Novel Series of Highly Potent Benzimidazole-Based Microsomal Triglyceride Transfer Protein Inhibitors

Synthesis of Novel Potent Dipeptidyl Peptidase IV Inhibitors with Enhanced Chemical Stability: Interplay between the N-Terminal Amino Acid Alkyl Side Chain and the Cyclopropyl Group of α-Aminoacyl-l-cis-4,5-methanoprolinenitrile-Based Inhibitors

Palladium-Catalyzed Microwave-Assisted Amination of 1-Bromonaphthalenes and 5- and 8-Bromoquinolines

Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors

Regioselectivity and diastereoselectivity in free-radical macrocyclization

Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors

NMR Structure of a Potent Small Molecule Inhibitor Bound to Human Keratinocyte Fatty Acid-Binding Protein

Seco-prolinenitrile inhibitors of dipeptidyl peptidase IV define minimal pharmacophore requirements at P1

Application of robotics to steady state enzyme kinetics: analysis of tight-binding inhibitors of dipeptidyl peptidase IV

Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents

Orally Active Squalene Synthase Inhibitors: Bis((acyloxy)alkyl) Prodrugs of the α-Phosphonosulfonic Acid Moiety

α-Phosphonosulfonic Acids: Potent and Selective Inhibitors of Squalene Synthase

1,1-Bisphosphonate Squalene Synthase Inhibitors: Interplay Between the Isoprenoid Subunit and the Diphosphate Surrogate

An MTP Inhibitor that Normalizes Atherogenic Lipoprotein Levels in WHHL Rabbits

Enantioselective Synthesis of α-Phosphono Sulfonate Squalene Synthase Inhibitors: Chiral Recognition in the Interactions of an α-Phosphono Sulfonate Inhibitor with Squalene Synthase

Free-radical macrocyclization-transannular cyclization

Free radical macrocyclization

Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo

An Efficient Palladium-Catalyzed Synthesis of γ,δ-Alkenyl-1,1-Bisphosphonates

Palladium-Catalyzed Microwave-Assisted Amination of 1-Bromonaphthalenes and 5- and 8-Bromoquinolines

A unified approach to prostanoid and corticosteroid synthons

Consensus classification of posterior cortical atrophy

Zika Virus Infection during Pregnancy and Effects on Early Childhood Development, French Polynesia, 2013-2016

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