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From carbohydrate leads to glycomimetic drugs

Nature reviews. Drug discovery, 2009-08, Vol.8 (8), p.661-677

2009

Volltextzugriff (PDF)

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

Nature communications, 2020-04, Vol.11 (1), p.2042-2042, Article 2042

2020

Volltextzugriff (PDF)

Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis

Nature cell biology, 2019-05, Vol.21 (5), p.627

2019

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GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice

Blood, 2010-09, Vol.116 (10), p.1779-1786

2010

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Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow

Blood, 2017-11, Vol.130 (19), p.2101-2110

2017

Volltextzugriff (PDF)

Phase 1 study of the E-selectin inhibitor GMI 1070 in patients with sickle cell anemia

PloS one, 2014-07, Vol.9 (7), p.e101301

2014

Volltextzugriff (PDF)

FLT3 inhibitors upregulate CXCR4 and E-selectin ligands via ERK suppression in AML cells and CXCR4/E-selectin inhibition enhances anti-leukemia efficacy of FLT3-targeted therapy in AML

Leukemia, 2023-06, Vol.37 (6), p.1379-1383

2023

Volltextzugriff (PDF)

Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance

Nature medicine, 2012-11, Vol.18 (11), p.1651

2012

Volltextzugriff (PDF)

Phase 1/2 study of uproleselan added to chemotherapy in patients with relapsed or refractory acute myeloid leukemia

Blood, 2022-02, Vol.139 (8), p.1135-1146

2022

Volltextzugriff (PDF)

Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use

Blood, 2015-04, Vol.125 (17), p.2656-2664

2015

Volltextzugriff (PDF)

Clinical Trials and Applications of Galectin Antagonists

Trends in Glycoscience and Glycotechnology, 2018/05/25, Vol.30(172), pp.SE211-SE220

2018

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Combining 5-azacitidine with the E-selectin antagonist uproleselan is an effective strategy to augment responses in myelodysplasia and acute myeloid leukaemia

British journal of haematology, 2024-06, Vol.204 (6), p.2264-2274

2024

Volltextzugriff (PDF)

Targeting Neutrophil Adhesive Events to Address Vaso-Occlusive Crisis in Sickle Cell Patients

Frontiers in immunology, 2021-04, Vol.12, p.663886-663886

2021

Volltextzugriff (PDF)

E-selectin-targeting lipid nanoparticles improve therapeutic efficacy and reduce side effects of bortezomib in multiple myeloma

Blood cancer journal (New York), 2023-04, Vol.13 (1), p.48-48, Article 48

2023

Volltextzugriff (PDF)

A randomized clinical trial of the efficacy and safety of rivipansel for sickle cell vaso-occlusive crisis

Blood, 2023-01, Vol.141 (2), p.168-179

2023

Volltextzugriff (PDF)

Targeting hematologic malignancies by inhibiting E-selectin: A sweet spot for AML therapy?

Blood reviews, 2024-05, Vol.65, p.101184-101184, Article 101184

2024

Volltextzugriff (PDF)

P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment

Blood, 2012-02, Vol.119 (6), p.1468-1478

2012

Volltextzugriff (PDF)

E-selectin inhibition with GMI-1271 decreases venous thrombosis without profoundly affecting tail vein bleeding in a mouse model

Thrombosis and haemostasis, 2017, Vol.117 (6), p.1171

2017

Volltextzugriff (PDF)

Inhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy

Blood cancer journal (New York), 2019-08, Vol.9 (9), p.68-6, Article 68

2019

Volltextzugriff (PDF)

Use of GMI‐1271, an E‐selectin antagonist, in healthy subjects and in 2 patients with calf vein thrombosis

Research and practice in thrombosis and haemostasis, 2020-02, Vol.4 (2), p.193-204

2020

Volltextzugriff (PDF)

Training the next generation of biomedical investigators in glycosciences

The Journal of clinical investigation, 2016-02, Vol.126 (2), p.405-408

2016

Volltextzugriff (PDF)

Reflection on the discovery of carcinoembryonic antigen, prostate-specific antigen, and cancer antigens CA125 and CA19-9

Clinical chemistry (Baltimore, Md.), 2013-01, Vol.59 (1), p.22-31

2013

Volltextzugriff (PDF)

P‐ and E‐selectin receptor antagonism prevents human leukocyte adhesion to activated porcine endothelial monolayers and attenuates porcine endothelial damage

Xenotransplantation (Københaven), 2018-03, Vol.25 (2), p.e12381-n/a

2018

Volltextzugriff (PDF)

E-selectin inhibitor is superior to low-molecular-weight heparin for the treatment of experimental venous thrombosis

Journal of vascular surgery. Venous and lymphatic disorders (New York, NY), 2022-01, Vol.10 (1), p.211-220

2022

Volltextzugriff (PDF)

Pre-organization of the Core Structure of E-Selectin Antagonists

Chemistry : a European journal, 2012-01, Vol.18 (5), p.1342-1351

2012

Volltextzugriff (PDF)

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From carbohydrate leads to glycomimetic drugs

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis

GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice

Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow

Phase 1 study of the E-selectin inhibitor GMI 1070 in patients with sickle cell anemia

FLT3 inhibitors upregulate CXCR4 and E-selectin ligands via ERK suppression in AML cells and CXCR4/E-selectin inhibition enhances anti-leukemia efficacy of FLT3-targeted therapy in AML

Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance

Phase 1/2 study of uproleselan added to chemotherapy in patients with relapsed or refractory acute myeloid leukemia

Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use

Clinical Trials and Applications of Galectin Antagonists

Combining 5-azacitidine with the E-selectin antagonist uproleselan is an effective strategy to augment responses in myelodysplasia and acute myeloid leukaemia

Targeting Neutrophil Adhesive Events to Address Vaso-Occlusive Crisis in Sickle Cell Patients

E-selectin-targeting lipid nanoparticles improve therapeutic efficacy and reduce side effects of bortezomib in multiple myeloma

A randomized clinical trial of the efficacy and safety of rivipansel for sickle cell vaso-occlusive crisis

Targeting hematologic malignancies by inhibiting E-selectin: A sweet spot for AML therapy?

P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment

E-selectin inhibition with GMI-1271 decreases venous thrombosis without profoundly affecting tail vein bleeding in a mouse model

Inhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy

Use of GMI‐1271, an E‐selectin antagonist, in healthy subjects and in 2 patients with calf vein thrombosis

Training the next generation of biomedical investigators in glycosciences

Reflection on the discovery of carcinoembryonic antigen, prostate-specific antigen, and cancer antigens CA125 and CA19-9

P‐ and E‐selectin receptor antagonism prevents human leukocyte adhesion to activated porcine endothelial monolayers and attenuates porcine endothelial damage

E-selectin inhibitor is superior to low-molecular-weight heparin for the treatment of experimental venous thrombosis

Pre-organization of the Core Structure of E-Selectin Antagonists

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