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The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials

The Journal of biological chemistry, 2011-01, Vol.286 (2), p.987-996

2011

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Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds

The Journal of biological chemistry, 2007-03, Vol.282 (13), p.9372-9382

2007

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The role of metabolic activation in drug-induced hepatotoxicity

Annual review of pharmacology and toxicology, 2005-01, Vol.45 (1), p.177-202

2005

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Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine

British journal of clinical pharmacology, 2021-06, Vol.87 (6), p.2572-2588

2021

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Acyl glucuronides: the good, the bad and the ugly

Biopharmaceutics & drug disposition, 2010-10, Vol.31 (7), p.367-395

2010

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Comparison of the Reactivity of Antimalarial 1,2,4,5-Tetraoxanes with 1,2,4-Trioxolanes in the Presence of Ferrous Iron Salts, Heme, and Ferrous Iron Salts/Phosphatidylcholine

Journal of medicinal chemistry, 2011-10, Vol.54 (19), p.6443-6455

2011

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Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients

Chemical research in toxicology, 2017-07, Vol.30 (7), p.1419-1435

2017

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Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients

The Journal of pharmacology and experimental therapeutics, 2014-08, Vol.350 (2), p.387

2014

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Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients

The Journal of pharmacology and experimental therapeutics, 2011-09, Vol.338 (3), p.841

2011

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Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Archives of toxicology, 2019-02, Vol.93 (2), p.385-399

2019

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Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin

Chemical research in toxicology, 2015-01, Vol.28 (1), p.51-58

2015

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Dapsone and Nitroso Dapsone Activation of Naı̈ve T‑Cells from Healthy Donors

Chemical research in toxicology, 2017-12, Vol.30 (12), p.2174-2186

2017

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An update on primary sclerosing cholangitis

Current opinion in gastroenterology, 2008-05, Vol.24 (3), p.377-383

2008

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An update on primary sclerosing cholangitis

Current opinion in gastroenterology, 2008-05, Vol.24 (3), p.377-383

2008

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Quantifying the metabolic activation of nevirapine in patients by integrated applications of NMR and mass spectrometries

Drug metabolism and disposition, 2010-01, Vol.38 (1), p.122

2010

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Characterization of Peroxidases Expressed in Human Antigen Presenting Cells and Analysis of the Covalent Binding of Nitroso Sulfamethoxazole to Myeloperoxidase

Chemical research in toxicology, 2015-01, Vol.28 (1), p.144-154

2015

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Acyl Glucuronides: Biological Activity, Chemical Reactivity, and Chemical Synthesis

Journal of medicinal chemistry, 2006-11, Vol.49 (24), p.6931-6945

2006

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Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles

Organic & biomolecular chemistry, 2013-12, Vol.11 (48), p.8426-8434

2013

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Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation

Chemical research in toxicology, 2009-05, Vol.22 (5), p.937-948

2009

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Abacavir Forms Novel Cross-Linking Abacavir Protein Adducts in Patients

Chemical research in toxicology, 2014-04, Vol.27 (4), p.524-535

2014

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Convenient Syntheses of Benzo-Fluorinated Dibenz[b,f]azepines: Rearrangements of Isatins, Acridines, and Indoles

Organic letters, 2011-10, Vol.13 (20), p.5592-5595

2011

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Syntheses and Characterization of the Acyl Glucuronide and Hydroxy Metabolites of Diclofenac

Journal of medicinal chemistry, 2004-05, Vol.47 (11), p.2816-2825

2004

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Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century

Journal of medicinal chemistry, 2009-03, Vol.52 (5), p.1408-1415

2009

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Haloarene Derivatives of Carbamazepine with Reduced Bioactivation Liabilities: 2‑Monohalo and 2,8-Dihalo Derivatives

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.9773-9784

2012

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Covalent Binding of the Nitroso Metabolite of Sulfamethoxazole Leads to Toxicity and Major Histocompatibility Complex-Restricted Antigen Presentation

Molecular pharmacology, 2002-09, Vol.62 (3), p.628-637

2002

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The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials

Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds

The role of metabolic activation in drug-induced hepatotoxicity

Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine

Acyl glucuronides: the good, the bad and the ugly

Comparison of the Reactivity of Antimalarial 1,2,4,5-Tetraoxanes with 1,2,4-Trioxolanes in the Presence of Ferrous Iron Salts, Heme, and Ferrous Iron Salts/Phosphatidylcholine

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients

Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients

Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin

Dapsone and Nitroso Dapsone Activation of Naı̈ve T‑Cells from Healthy Donors

An update on primary sclerosing cholangitis

An update on primary sclerosing cholangitis

Quantifying the metabolic activation of nevirapine in patients by integrated applications of NMR and mass spectrometries

Characterization of Peroxidases Expressed in Human Antigen Presenting Cells and Analysis of the Covalent Binding of Nitroso Sulfamethoxazole to Myeloperoxidase

Acyl Glucuronides: Biological Activity, Chemical Reactivity, and Chemical Synthesis

Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles

Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation

Abacavir Forms Novel Cross-Linking Abacavir Protein Adducts in Patients

Convenient Syntheses of Benzo-Fluorinated Dibenz[b,f]azepines: Rearrangements of Isatins, Acridines, and Indoles

Syntheses and Characterization of the Acyl Glucuronide and Hydroxy Metabolites of Diclofenac

Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century

Haloarene Derivatives of Carbamazepine with Reduced Bioactivation Liabilities: 2‑Monohalo and 2,8-Dihalo Derivatives

Covalent Binding of the Nitroso Metabolite of Sulfamethoxazole Leads to Toxicity and Major Histocompatibility Complex-Restricted Antigen Presentation

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