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Tachykinin receptor antagonists in clinical trials

Expert opinion on investigational drugs, 2009-12, Vol.18 (12), p.1843-1864

2009

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Nitric Oxide Promotes Proliferation and Plasminogen Activator Production by Coronary Venular Endothelium Through Endogenous bFGF

Circulation research, 1997-06, Vol.80 (6), p.845-852

1997

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Cardioprotective effects of zofenopril, a new angiotensin-converting enzyme inhibitor, on doxorubicin-induced cardiotoxicity in the rat

European journal of pharmacology, 2001-02, Vol.414 (1), p.71-78

2001

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A novel tachykinin NK2 receptor antagonist prevents motility‐stimulating effects of neurokinin A in small intestine

British journal of pharmacology, 2001-09, Vol.134 (1), p.215-223

2001

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Lead Optimization of P5U and Urantide: Discovery of Novel Potent Ligands at the Urotensin-II Receptor

Journal of medicinal chemistry, 2014-07, Vol.57 (14), p.5965-5974

2014

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Su1161 The Response Rate After Single and Repeated Doses of Nepadutant As Symptomatic Treatment of Infant Colic: the NO-CRY Phase II Clinical Trial

Gastroenterology (New York, N.Y. 1943), 2015-04, Vol.148 (4), p.S-424-S-424

2015

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Su1377 Efficacy of Oral Ibodutant in IBS-D Female Patients Measured by Abdominal Pain Severity - An Iris 2 Post-Hoc Analysis

Gastroenterology (New York, N.Y. 1943), 2015-04, Vol.148 (4), p.S-491-S-491

2015

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Mo2041 Effect of Ibodutant, a Neurokinin NK2 Receptor Antagonist, on Gender-Related Influences Following Induction of Trinitrobenzenesulfonic Acid-Induced Colitis in the Guinea Pig

Gastroenterology (New York, N.Y. 1943), 2015-04, Vol.148 (4), p.S-777-S-777

2015

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Su1160 A Randomized, Double-Blind, Placebo-Controlled Phase II Study to Evaluate the Efficacy of 7 Days of Orally Administered Nepadutant in Infants With Colic - the NO-CRY Study

Gastroenterology (New York, N.Y. 1943), 2015-04, Vol.148 (4), p.S-423-S-424

2015

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Su1376 Assessment of IBS-D Severity: A Case Study From Two Randomized, Double-Blind, Placebo-Controlled Pivotal Trials to Evaluate the Efficacy of Oral Ibodutant

Gastroenterology (New York, N.Y. 1943), 2015-04, Vol.148 (4), p.S-490-S-491

2015

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Structure-Activity Study of the Peptides P5U and Urantide by the Development of Analogues Containing Uncoded Amino Acids at Position 9

ChemMedChem, 2016-08, Vol.11 (16), p.1856-1864

2016

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Structure-Activity Study of the Peptides P5U and Urantide by the Development of Analogues Containing Uncoded Amino Acids at Position9

ChemMedChem, 2016-08, Vol.11 (16), p.1856-1864

2016

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Effect of nepadutant, a neurokinin 2 tachykinin receptor antagonist, on immediate-early gene expression after trinitrobenzenesulfonic acid-induced colitis in the rat

The Journal of pharmacology and experimental therapeutics, 2003-01, Vol.304 (1), p.272

2003

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Benzofused hydroxamic acids: Useful fragments for the preparation of histone deacetylase inhibitors. Part 2: 7-Fluorobenzothiophenes and benzofurans

Bioorganic & medicinal chemistry letters, 2015-04, Vol.25 (7), p.1603-1606

2015

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Benzofused hydroxamic acids: Useful fragments for the preparation of histone deacetylase inhibitors. Part 1: Hit identification

Bioorganic & medicinal chemistry letters, 2013-07, Vol.23 (14), p.4091-4095

2013

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Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors

Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (8), p.2305-2308

2011

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Pharmacological evaluation of the role of cyclooxygenase isoenzymes on the micturition reflex following experimental cystitis in rats

British journal of pharmacology, 2000-05, Vol.130 (2), p.331-338

2000

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A New, Potent Urotensin II Receptor Peptide Agonist Containing a Pen Residue at the Disulfide Bridge

Journal of medicinal chemistry, 2002-09, Vol.45 (20), p.4391-4394

2002

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Structure−Activity Relationships of 6-Methyl-benzo[b]thiophene-2-carboxylic Acid (1-{(S)-1-Benzyl-4-[4-(tetrahydropyran-4-ylmethyl)piperazin-1-yl]butylcarbamoyl}cyclopentyl)amide, Potent Antagonist of the Neurokinin-2 Receptor

Journal of medicinal chemistry, 2010-05, Vol.53 (10), p.4148-4165

2010

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New Insight into the Binding Mode of Peptide Ligands at Urotensin-II Receptor: Structure−Activity Relationships Study on P5U and Urantide

Journal of medicinal chemistry, 2009-07, Vol.52 (13), p.3927-3940

2009

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4- N-Hydroxy-4-[1-(sulfonyl)piperidin-4-yl]-butyramides as HDAC inhibitors

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (22), p.6767-6769

2011

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A New Class of Pseudopeptide Antagonists of the Kinin B1 Receptor Containing Alkyl Spacers

Journal of medicinal chemistry, 1999-02, Vol.42 (3), p.409-414

1999

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The troubled story of tachykinins and neurokinins

Trends in pharmacological sciences (Regular ed.), 2000-05, Vol.21 (5), p.173-175

Maggi, Carlo A

2000

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Evidence for the involvement of P2‐purinoceptors in the cholinergic contraction of the guinea‐pig ileum

British journal of pharmacology, 1997-08, Vol.121 (8), p.1507-1508

1997

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MicroRNA-130b Promotes Tumor Development and Is Associated with Poor Prognosis in Colorectal Cancer

Neoplasia (New York, N.Y.), 2013-09, Vol.15 (9), p.1086-1099

2013

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Tachykinin receptor antagonists in clinical trials

Nitric Oxide Promotes Proliferation and Plasminogen Activator Production by Coronary Venular Endothelium Through Endogenous bFGF

Cardioprotective effects of zofenopril, a new angiotensin-converting enzyme inhibitor, on doxorubicin-induced cardiotoxicity in the rat

A novel tachykinin NK2 receptor antagonist prevents motility‐stimulating effects of neurokinin A in small intestine

Lead Optimization of P5U and Urantide: Discovery of Novel Potent Ligands at the Urotensin-II Receptor

Su1161 The Response Rate After Single and Repeated Doses of Nepadutant As Symptomatic Treatment of Infant Colic: the NO-CRY Phase II Clinical Trial

Su1377 Efficacy of Oral Ibodutant in IBS-D Female Patients Measured by Abdominal Pain Severity - An Iris 2 Post-Hoc Analysis

Mo2041 Effect of Ibodutant, a Neurokinin NK2 Receptor Antagonist, on Gender-Related Influences Following Induction of Trinitrobenzenesulfonic Acid-Induced Colitis in the Guinea Pig

Su1160 A Randomized, Double-Blind, Placebo-Controlled Phase II Study to Evaluate the Efficacy of 7 Days of Orally Administered Nepadutant in Infants With Colic - the NO-CRY Study

Su1376 Assessment of IBS-D Severity: A Case Study From Two Randomized, Double-Blind, Placebo-Controlled Pivotal Trials to Evaluate the Efficacy of Oral Ibodutant

Structure-Activity Study of the Peptides P5U and Urantide by the Development of Analogues Containing Uncoded Amino Acids at Position 9

Structure-Activity Study of the Peptides P5U and Urantide by the Development of Analogues Containing Uncoded Amino Acids at Position9

Effect of nepadutant, a neurokinin 2 tachykinin receptor antagonist, on immediate-early gene expression after trinitrobenzenesulfonic acid-induced colitis in the rat

Benzofused hydroxamic acids: Useful fragments for the preparation of histone deacetylase inhibitors. Part 2: 7-Fluorobenzothiophenes and benzofurans

Benzofused hydroxamic acids: Useful fragments for the preparation of histone deacetylase inhibitors. Part 1: Hit identification

Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors

Pharmacological evaluation of the role of cyclooxygenase isoenzymes on the micturition reflex following experimental cystitis in rats

A New, Potent Urotensin II Receptor Peptide Agonist Containing a Pen Residue at the Disulfide Bridge

Structure−Activity Relationships of 6-Methyl-benzo[b]thiophene-2-carboxylic Acid (1-{(S)-1-Benzyl-4-[4-(tetrahydropyran-4-ylmethyl)piperazin-1-yl]butylcarbamoyl}cyclopentyl)amide, Potent Antagonist of the Neurokinin-2 Receptor

New Insight into the Binding Mode of Peptide Ligands at Urotensin-II Receptor: Structure−Activity Relationships Study on P5U and Urantide

4- N-Hydroxy-4-[1-(sulfonyl)piperidin-4-yl]-butyramides as HDAC inhibitors

A New Class of Pseudopeptide Antagonists of the Kinin B1 Receptor Containing Alkyl Spacers

The troubled story of tachykinins and neurokinins

Evidence for the involvement of P2‐purinoceptors in the cholinergic contraction of the guinea‐pig ileum

MicroRNA-130b Promotes Tumor Development and Is Associated with Poor Prognosis in Colorectal Cancer

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