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Extracellular vesicles: biology and emerging therapeutic opportunities

Nature reviews. Drug discovery, 2013-05, Vol.12 (5), p.347-357

2013

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Cells release subpopulations of exosomes with distinct molecular and biological properties

Scientific reports, 2016-03, Vol.6 (1), p.22519-22519, Article 22519

2016

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Reproducible and scalable purification of extracellular vesicles using combined bind-elute and size exclusion chromatography

Scientific reports, 2017-09, Vol.7 (1), p.11561-10, Article 11561

2017

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Extracellular vesicles in neurodegenerative disease - pathogenesis to biomarkers

Nature reviews. Neurology, 2016-06, Vol.12 (6), p.346-357

2016

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Therapeutic Potential of Multipotent Mesenchymal Stromal Cells and Their Extracellular Vesicles

Human gene therapy, 2015-08, Vol.26 (8), p.506-517

2015

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Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle

Biomaterials, 2021-01, Vol.266, p.120435-120435, Article 120435

2021

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Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics

Biomaterials, 2022-11, Vol.290, p.121830-121830, Article 121830

2022

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Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

Frontiers in immunology, 2018-04, Vol.9, p.738-738

2018

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Extracellular microRNAs exhibit sequence-dependent stability and cellular release kinetics

RNA biology, 2019-05, Vol.16 (5), p.696-706

2019

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CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis

Clinical proteomics, 2020-08, Vol.17 (1), p.31-31, Article 31

2020

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A Peptide-based Vector for Efficient Gene Transfer In Vitro and In Vivo

Molecular therapy, 2011-08, Vol.19 (8), p.1457-1467

2011

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GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain

Nature communications, 2021-11, Vol.12 (1), p.6666-6666, Article 6666

2021

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Delivery of nucleic acids with a stearylated (RxR) 4 peptide using a non-covalent co-incubation strategy

Journal of controlled release, 2010-01, Vol.141 (1), p.42-51

2010

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Assessing the uptake kinetics and internalization mechanisms of cell-penetrating peptides using a quenched fluorescence assay

Biochimica et biophysica acta, 2010-03, Vol.1798 (3), p.338-343

2010

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Efficient Doxorubicin Loading to Isolated Dexosomes of Immature JAWSII Cells: Formulated and Characterized as the Bionanomaterial

Materials, 2020-07, Vol.13 (15), p.3344

2020

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Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

Molecular therapy, 2017-07, Vol.25 (7), p.1580-1587

2017

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Fine Tuning of Phosphorothioate Inclusion in 2′-O-Methyl Oligonucleotides Contributes to Specific Cell Targeting for Splice-Switching Modulation

Frontiers in physiology, 2021-10, Vol.12, p.689179-689179

2021

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A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

Nature communications, 2020-02, Vol.11 (1), p.1113-1113, Article 1113

2020

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In vivo biodistribution and efficacy of peptide mediated delivery

Trends in pharmacological sciences (Regular ed.), 2010-11, Vol.31 (11), p.528-535

2010

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Antibody-displaying extracellular vesicles for targeted cancer therapy

Nature biomedical engineering, 2024-05

2024

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Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome

Scientific reports, 2018-07, Vol.8 (1), p.10813-12, Article 10813

2018

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C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia

Brain (London, England : 1878), 2017-04, Vol.140 (4), p.887-897

2017

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Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods

PloS one, 2015-12, Vol.10 (12), p.e0145686

2015

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Targeting blood-brain-barrier transcytosis – perspectives for drug delivery

Neuropharmacology, 2017-07, Vol.120, p.4-7

2017

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Preparation and Isolation of siRNA-Loaded Extracellular Vesicles

Methods in molecular biology (Clifton, N.J.), 2017-01, Vol.1545, p.197

2017

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Biochemistry & Molecular Biology
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Extracellular vesicles: biology and emerging therapeutic opportunities

Cells release subpopulations of exosomes with distinct molecular and biological properties

Reproducible and scalable purification of extracellular vesicles using combined bind-elute and size exclusion chromatography

Extracellular vesicles in neurodegenerative disease - pathogenesis to biomarkers

Therapeutic Potential of Multipotent Mesenchymal Stromal Cells and Their Extracellular Vesicles

Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle

Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

Extracellular microRNAs exhibit sequence-dependent stability and cellular release kinetics

CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis

A Peptide-based Vector for Efficient Gene Transfer In Vitro and In Vivo

GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain

Delivery of nucleic acids with a stearylated (RxR) 4 peptide using a non-covalent co-incubation strategy

Assessing the uptake kinetics and internalization mechanisms of cell-penetrating peptides using a quenched fluorescence assay

Efficient Doxorubicin Loading to Isolated Dexosomes of Immature JAWSII Cells: Formulated and Characterized as the Bionanomaterial

Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

Fine Tuning of Phosphorothioate Inclusion in 2′-O-Methyl Oligonucleotides Contributes to Specific Cell Targeting for Splice-Switching Modulation

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

In vivo biodistribution and efficacy of peptide mediated delivery

Antibody-displaying extracellular vesicles for targeted cancer therapy

Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome

C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia

Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods

Targeting blood-brain-barrier transcytosis – perspectives for drug delivery

Preparation and Isolation of siRNA-Loaded Extracellular Vesicles

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