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ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia

Cancer cell, 2018-03, Vol.33 (3), p.495-511.e12

2018

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Maturation-Promoting Activity of SATB1 in MGE-Derived Cortical Interneurons

Cell reports (Cambridge), 2012-11, Vol.2 (5), p.1351-1362

2012

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Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations

PloS one, 2020-05, Vol.15 (5), p.e0233468

2020

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Molecular markers of endometrial carcinoma detected in uterine aspirates

International journal of cancer, 2011-11, Vol.129 (10), p.2435-2444

2011

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Comprehensive in Vitro Characterization of the LSD1 Small Molecule Inhibitor Class in Oncology

ACS pharmacology & translational science, 2021-12, Vol.4 (6), p.1818-1834

2021

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endoglucanase is involved in infection of rice roots by the not-cellulose-metabolizing endophyte Azoarcus sp. strain BH72

Molecular plant-microbe interactions, 2006-02, Vol.19 (2), p.181-188

2006

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Down-regulation of the maize and Arabidopsis thaliana caffeic acid O-methyl-transferase genes by two new maize R2R3-MYB transcription factors

Plant molecular biology, 2006-12, Vol.62 (6), p.809-823

2006

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Efficacy of Vafidemstat in Experimental Autoimmune Encephalomyelitis Highlights the KDM1A/RCOR1/HDAC Epigenetic Axis in Multiple Sclerosis

Pharmaceutics, 2022-07, Vol.14 (7), p.1420

2022

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Advances in the development of histone lysine demethylase inhibitors

Current opinion in pharmacology, 2015-08, Vol.23, p.52-60

2015

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Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies

Neurobiology of disease, 2006-05, Vol.22 (2), p.265-273

2006

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Development of a novel splice array platform and its application in the identification of alternative splice variants in lung cancer

BMC genomics, 2010-06, Vol.11 (1), p.352-352

2010

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P2‐005: SAFETY EVALUATION OF VAFIDEMSTAT ON MILD TO MODERATE ALZHEIMER'S SUBJECTS

Alzheimer's & dementia, 2019-07, Vol.15, p.P572-P573

2019

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Understanding Epigenetic Alterations in Alzheimer's and Parkinson's Disease: Towards Targeted Biomarkers and Therapies

Current pharmaceutical design, 2017-01, Vol.23 (5), p.839-857

2017

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DNA Chip Technology in Brain Banks: Confronting a Degrading World

Journal of neuropathology and experimental neurology, 2004-10, Vol.63 (10), p.1003-1014

2004

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First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia

Journal of clinical oncology, 2020-12, Vol.38 (36), p.4260-4273

2020

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Transposon Display identifies individual transposable elements in high copy number lines

The Plant journal : for cell and molecular biology, 1998-01, Vol.13 (1), p.121-129

1998

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Orymold: ontology based gene expression data integration and analysis tool applied to rice

BMC bioinformatics, 2009-05, Vol.10 (158), p.158-158, Article 158

2009

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Direct Measurement of KDM1A Target Engagement Using Chemoprobe-based Immunoassays

Journal of visualized experiments, 2019-06 (148)

2019

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Targeting KDM1A with iadademstat in combination with immunotherapy in an in vivo model of melanoma

Journal of clinical oncology, 2019-05, Vol.37 (15_suppl), p.e14248-e14248

2019

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Vafidemstat in mild to moderate Alzheimer’s disease: The ETHERAL study European cohort interim analysis: Update on pharmacologic and nonpharmacologic interventions

Alzheimer's & dementia, 2020-12, Vol.16 (S6)

2020

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Vafidemstat in mild to moderate Alzheimer’s disease: The ETHERAL study European cohort interim analysis

Alzheimer's & dementia, 2020-12, Vol.16, p.n/a

2020

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Chemoprobe-based assays of histone lysine demethylase 1A target occupation enable in vivo pharmacokinetics and pharmacodynamics studies of KDM1A inhibitors

The Journal of biological chemistry, 2019-05, Vol.294 (20), p.8311-8322

2019

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A novel multi-functional KDM1A chemoprobe as a tool for clinical cancer research

Journal of clinical oncology, 2018-05, Vol.36 (15_suppl), p.e24242-e24242

2018

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Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia

Leukemia, 2020-05, Vol.34 (5), p.1266-1277

2020

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ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia

Maturation-Promoting Activity of SATB1 in MGE-Derived Cortical Interneurons

Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations

Molecular markers of endometrial carcinoma detected in uterine aspirates

Comprehensive in Vitro Characterization of the LSD1 Small Molecule Inhibitor Class in Oncology

endoglucanase is involved in infection of rice roots by the not-cellulose-metabolizing endophyte Azoarcus sp. strain BH72

Down-regulation of the maize and Arabidopsis thaliana caffeic acid O-methyl-transferase genes by two new maize R2R3-MYB transcription factors

Efficacy of Vafidemstat in Experimental Autoimmune Encephalomyelitis Highlights the KDM1A/RCOR1/HDAC Epigenetic Axis in Multiple Sclerosis

Advances in the development of histone lysine demethylase inhibitors

Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies

Development of a novel splice array platform and its application in the identification of alternative splice variants in lung cancer

Genomic resources for a commercial flatfish, the Senegalese sole (Solea senegalensis): EST sequencing, oligo microarray design, and development of the Soleamold bioinformatic platform

P2‐005: SAFETY EVALUATION OF VAFIDEMSTAT ON MILD TO MODERATE ALZHEIMER'S SUBJECTS

Understanding Epigenetic Alterations in Alzheimer's and Parkinson's Disease: Towards Targeted Biomarkers and Therapies

DNA Chip Technology in Brain Banks: Confronting a Degrading World

First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia

Transposon Display identifies individual transposable elements in high copy number lines

Orymold: ontology based gene expression data integration and analysis tool applied to rice

Direct Measurement of KDM1A Target Engagement Using Chemoprobe-based Immunoassays

Targeting KDM1A with iadademstat in combination with immunotherapy in an in vivo model of melanoma

Vafidemstat in mild to moderate Alzheimer’s disease: The ETHERAL study European cohort interim analysis: Update on pharmacologic and nonpharmacologic interventions

Vafidemstat in mild to moderate Alzheimer’s disease: The ETHERAL study European cohort interim analysis

Chemoprobe-based assays of histone lysine demethylase 1A target occupation enable in vivo pharmacokinetics and pharmacodynamics studies of KDM1A inhibitors

A novel multi-functional KDM1A chemoprobe as a tool for clinical cancer research

Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia

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