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Effective combinatorial immunotherapy for castration-resistant prostate cancer

Nature (London), 2017-03, Vol.543 (7647), p.728-732

2017

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Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast

Nature communications, 2021-08, Vol.12 (1), p.5024-5024, Article 5024

2021

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Simultaneous inhibition of CXCR1/2, TGF-β, and PD-L1 remodels the tumor and its microenvironment to drive antitumor immunity

Journal for immunotherapy of cancer, 2020-03, Vol.8 (1), p.e000326

2020

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Regression and Eradication of Triple-Negative Breast Carcinoma in 4T1 Mouse Model by Combination Immunotherapies

Cancers, 2023-04, Vol.15 (8), p.2366

2023

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Desmetramadol Is Identified as a G-Protein Biased µ Opioid Receptor Agonist

Frontiers in pharmacology, 2020-01, Vol.10, p.1680-1680

2020

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Vaccine Increases the Diversity and Activation of Intratumoral T Cells in the Context of Combination Immunotherapy

Cancers, 2021-02, Vol.13 (5), p.968

2021

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KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer

Cancer cell, 2019-04, Vol.35 (4), p.559-572.e7

2019

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Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models

Clinical cancer research, 2020-03, Vol.26 (6), p.1420-1431

2020

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Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC

Cancer discovery, 2022-01, Vol.12 (1), p.47-61

2022

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Neutrophil content predicts lymphocyte depletion and anti-PD1 treatment failure in NSCLC

JCI insight, 2019-12, Vol.4 (24)

2019

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Nicotinamide glycolates antagonize CXCR2 activity through an intracellular mechanism

The Journal of pharmacology and experimental therapeutics, 2010-01, Vol.332 (1), p.145

2010

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Desmetramadol Has the Safety and Analgesic Profile of Tramadol Without Its Metabolic Liabilities: Consecutive Randomized, Double-Blind, Placebo- and Active Comparator-Controlled Trials

The journal of pain, 2019-10, Vol.20 (10), p.1218-1235

2019

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Discovery of 2‑[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2

Journal of medicinal chemistry, 2014-10, Vol.57 (20), p.8378-8397

2014

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Targeting the chromatin effector Pygo2 promotes cytotoxic T cell responses and overcomes immunotherapy resistance in prostate cancer

Science immunology, 2023-03, Vol.8 (81), p.eade4656

2023

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Erratum: Effective combinatorial immunotherapy for castration-resistant prostate cancer

Nature (London), 2017-05, Vol.545 (7652), p.116-116

2017

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Identification of a New Class of Molecules, the Arachidonyl Amino Acids, and Characterization of One Member That Inhibits Pain

The Journal of biological chemistry, 2001-11, Vol.276 (46), p.42639-42644

2001

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Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility and oral bioavailability

Bioorganic & medicinal chemistry letters, 2015-09, Vol.25 (18), p.3793-3797

2015

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Boronic acid-containing CXCR1/2 antagonists: Optimization of metabolic stability, in vivo evaluation, and a proposed receptor binding model

Bioorganic & medicinal chemistry letters, 2015-06, Vol.25 (11), p.2280-2284

2015

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Intestinal transport of aminopterin enantiomers in dogs and humans with psoriasis is stereoselective: evidence for a mechanism involving the proton-coupled folate transporter

The Journal of pharmacology and experimental therapeutics, 2012-09, Vol.342 (3), p.696

2012

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Increased Acyclovir Oral Bioavailability via a Bile Acid Conjugate

Molecular pharmaceutics, 2004-01, Vol.1 (1), p.40-48

2004

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IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung

American journal of physiology. Lung cellular and molecular physiology, 2009-09, Vol.297 (3), p.L512-L519

2009

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Snap-to-it probes: chelate-constrained nucleobase oligomers with enhanced binding specificity

Nucleic acids research, 2008-06, Vol.36 (11), p.3522

2008

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Bivalent inhibitors of glutathione S-transferase: The effect of spacer length on isozyme selectivity

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (14), p.3780-3783

2006

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Phase 1 Results of the First-in-Class CXCR1/2 Inhibitor SX-682 in Patients with Hypomethylating Agent Failure Myelodysplastic Syndromes

Blood, 2022-11, Vol.140 (Supplement 1), p.2070-2072

2022

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Effective combinatorial immunotherapy for castration-resistant prostate cancer

Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast

Simultaneous inhibition of CXCR1/2, TGF-β, and PD-L1 remodels the tumor and its microenvironment to drive antitumor immunity

Regression and Eradication of Triple-Negative Breast Carcinoma in 4T1 Mouse Model by Combination Immunotherapies

Desmetramadol Is Identified as a G-Protein Biased µ Opioid Receptor Agonist

Vaccine Increases the Diversity and Activation of Intratumoral T Cells in the Context of Combination Immunotherapy

KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer

Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models

Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC

Neutrophil content predicts lymphocyte depletion and anti-PD1 treatment failure in NSCLC

Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer

Nicotinamide glycolates antagonize CXCR2 activity through an intracellular mechanism

Desmetramadol Has the Safety and Analgesic Profile of Tramadol Without Its Metabolic Liabilities: Consecutive Randomized, Double-Blind, Placebo- and Active Comparator-Controlled Trials

Discovery of 2‑[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2

Targeting the chromatin effector Pygo2 promotes cytotoxic T cell responses and overcomes immunotherapy resistance in prostate cancer

Erratum: Effective combinatorial immunotherapy for castration-resistant prostate cancer

Identification of a New Class of Molecules, the Arachidonyl Amino Acids, and Characterization of One Member That Inhibits Pain

Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility and oral bioavailability

Boronic acid-containing CXCR1/2 antagonists: Optimization of metabolic stability, in vivo evaluation, and a proposed receptor binding model

Intestinal transport of aminopterin enantiomers in dogs and humans with psoriasis is stereoselective: evidence for a mechanism involving the proton-coupled folate transporter

Increased Acyclovir Oral Bioavailability via a Bile Acid Conjugate

IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung

Snap-to-it probes: chelate-constrained nucleobase oligomers with enhanced binding specificity

Bivalent inhibitors of glutathione S-transferase: The effect of spacer length on isozyme selectivity

Phase 1 Results of the First-in-Class CXCR1/2 Inhibitor SX-682 in Patients with Hypomethylating Agent Failure Myelodysplastic Syndromes

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