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Drug Resistance Conferred by Mutations Outside the Active Site through Alterations in the Dynamic and Structural Ensemble of HIV‑1 Protease

Journal of the American Chemical Society, 2014-08, Vol.136 (34), p.11956-11963

2014

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Hydrophobic Core Flexibility Modulates Enzyme Activity in HIV-1 Protease

Journal of the American Chemical Society, 2012-03, Vol.134 (9), p.4163-4168

2012

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Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance

Journal of Virology, 2010-05, Vol.84 (10), p.5368-5378

2010

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Extreme Entropy–Enthalpy Compensation in a Drug-Resistant Variant of HIV-1 Protease

ACS chemical biology, 2012-09, Vol.7 (9), p.1536-1546

2012

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HIV-1 Protease Inhibitors from Inverse Design in the Substrate Envelope Exhibit Subnanomolar Binding to Drug-Resistant Variants

Journal of the American Chemical Society, 2008-05, Vol.130 (19), p.6099-6113

2008

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TMC310911, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, Shows In Vitro an Improved Resistance Profile and Higher Genetic Barrier to Resistance Compared with Current Protease Inhibitors

Antimicrobial Agents and Chemotherapy, 2011-12, Vol.55 (12), p.5723-5731

2011

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Crystal Structure of Lysine Sulfonamide Inhibitor Reveals the Displacement of the Conserved Flap Water Molecule in Human Immunodeficiency Virus Type 1 Protease

Journal of Virology, 2007-09, Vol.81 (17), p.9512-9518

2007

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Specificity of Translation for N-Alkyl Amino Acids

Journal of the American Chemical Society, 2007-09, Vol.129 (37), p.11316-11317

2007

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Design and Synthesis of HIV-1 Protease Inhibitors Incorporating Oxazolidinones as P2/P2‘ Ligands in Pseudosymmetric Dipeptide Isosteres

Journal of medicinal chemistry, 2007-09, Vol.50 (18), p.4316-4328

2007

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Design, Synthesis, and Biological and Structural Evaluations of Novel HIV-1 Protease Inhibitors To Combat Drug Resistance

Journal of medicinal chemistry, 2012-07, Vol.55 (14), p.6328-6341

2012

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Testing the Substrate-Envelope Hypothesis with Designed Pairs of Compounds

ACS chemical biology, 2013-11, Vol.8 (11), p.2433-2441

2013

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Discovery of HIV-1 Protease Inhibitors with Picomolar Affinities Incorporating N-Aryl-oxazolidinone-5-carboxamides as Novel P2 Ligands

Journal of medicinal chemistry, 2006-12, Vol.49 (25), p.7342-7356

2006

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Molecular Basis for Drug Resistance in HIV-1 Protease

Viruses, 2010-11, Vol.2 (11), p.2509-2535

2010

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Efficient Computation of Small-Molecule Configurational Binding Entropy and Free Energy Changes by Ensemble Enumeration

Journal of chemical theory and computation, 2013-11, Vol.9 (11), p.5098-5115

2013

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Structural and Thermodynamic Basis of Amprenavir/Darunavir and Atazanavir Resistance in HIV-1 Protease with Mutations at Residue 50

Journal of Virology, 2013-04, Vol.87 (8), p.4176-4184

2013

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Programming Peptidomimetic Syntheses by Translating Genetic Codes Designed de novo

Proceedings of the National Academy of Sciences - PNAS, 2003-05, Vol.100 (11), p.6353-6357

2003

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Crystal Structure of the APOBEC3G Catalytic Domain Reveals Potential Oligomerization Interfaces

Structure (London), 2010-01, Vol.18 (1), p.28-38

2010

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Design of Mutation-resistant HIV Protease Inhibitors with the Substrate Envelope Hypothesis

Chemical biology & drug design, 2007-05, Vol.69 (5), p.298-313

2007

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Substrate Envelope-Designed Potent HIV-1 Protease Inhibitors to Avoid Drug Resistance

Chemistry & biology, 2013-09, Vol.20 (9), p.1116-1124

2013

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Crystal Structure of the APOBEC3G Catalytic Domain Reveals Potential Oligomerization Interfaces

Structure (London), 2010-01, Vol.18 (1)

2010

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Specificity of Translation for N-Alkyl Amino Acids

Journal of the American Chemical Society, 2007-08, Vol.129 (37), p.11316-11317

2007

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Synthese und Eigenschaften von 2-Cyanimino-l,3-dimethylimidazolin [1] / Synthesis and Properties of 2-Cyanimino-l,3-dimethylimidazoline [1]

Zeitschrift für Naturforschung. B, A journal of chemical sciences, 2001-10, Vol.56 (10), p.1015-1019

2001

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Specificity of Translation for N-Alkyl Amino Acids

Journal of the American Chemical Society, 2007-01, Vol.129 (37), p.11316-11317

2007

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ChemInform Abstract: Derivatives of Imidazoles. Part 43. Synthesis and Properties of 2-Cyanimino-1,3-dimethylimidazoline

ChemInform, 2002-03, Vol.33 (9), p.no-no

2002

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Drug Resistance Conferred by Mutations Outside the Active Site through Alterations in the Dynamic and Structural Ensemble of HIV‑1 Protease

Hydrophobic Core Flexibility Modulates Enzyme Activity in HIV-1 Protease

Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance

Extreme Entropy–Enthalpy Compensation in a Drug-Resistant Variant of HIV-1 Protease

HIV-1 Protease Inhibitors from Inverse Design in the Substrate Envelope Exhibit Subnanomolar Binding to Drug-Resistant Variants

TMC310911, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, Shows In Vitro an Improved Resistance Profile and Higher Genetic Barrier to Resistance Compared with Current Protease Inhibitors

Crystal Structure of Lysine Sulfonamide Inhibitor Reveals the Displacement of the Conserved Flap Water Molecule in Human Immunodeficiency Virus Type 1 Protease

Specificity of Translation for N-Alkyl Amino Acids

Design and Synthesis of HIV-1 Protease Inhibitors Incorporating Oxazolidinones as P2/P2‘ Ligands in Pseudosymmetric Dipeptide Isosteres

Design, Synthesis, and Biological and Structural Evaluations of Novel HIV-1 Protease Inhibitors To Combat Drug Resistance

Testing the Substrate-Envelope Hypothesis with Designed Pairs of Compounds

Discovery of HIV-1 Protease Inhibitors with Picomolar Affinities Incorporating N-Aryl-oxazolidinone-5-carboxamides as Novel P2 Ligands

Molecular Basis for Drug Resistance in HIV-1 Protease

Efficient Computation of Small-Molecule Configurational Binding Entropy and Free Energy Changes by Ensemble Enumeration

Structural and Thermodynamic Basis of Amprenavir/Darunavir and Atazanavir Resistance in HIV-1 Protease with Mutations at Residue 50

Programming Peptidomimetic Syntheses by Translating Genetic Codes Designed de novo

Crystal Structure of the APOBEC3G Catalytic Domain Reveals Potential Oligomerization Interfaces

Design of Mutation-resistant HIV Protease Inhibitors with the Substrate Envelope Hypothesis

Substrate Envelope-Designed Potent HIV-1 Protease Inhibitors to Avoid Drug Resistance

Crystal Structure of the APOBEC3G Catalytic Domain Reveals Potential Oligomerization Interfaces

Specificity of Translation for N-Alkyl Amino Acids

Synthese und Eigenschaften von 2-Cyanimino-l,3-dimethylimidazolin [1] / Synthesis and Properties of 2-Cyanimino-l,3-dimethylimidazoline [1]

Specificity of Translation for N-Alkyl Amino Acids

ChemInform Abstract: Derivatives of Imidazoles. Part 43. Synthesis and Properties of 2-Cyanimino-1,3-dimethylimidazoline

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