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Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

Pharmaceutical research, 2014-08, Vol.31 (8), p.2203-2219

2014

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Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs

Drug metabolism and disposition, 2007-10, Vol.35 (10), p.1766-1780

2007

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Developing Clinically Relevant Dissolution Specifications for Oral Drug Products-Industrial and Regulatory Perspectives

Pharmaceutics, 2019-12, Vol.12 (1), p.19

2019

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Discovery of 3‑Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3‑a]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

Journal of medicinal chemistry, 2012-10, Vol.55 (20), p.8770-8789

2012

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The prediction of drug metabolism, tissue distribution, and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools

Drug metabolism and disposition, 2007-04, Vol.35 (4), p.649-659

2007

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Novel generic UPLC/MS/MS method for high throughput analysis applied to permeability assessment in early Drug Discovery

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007-03, Vol.847 (2), p.182-187

2007

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Developing Clinically Relevant Dissolution Specifications (CRDSs) for Oral Drug Products: Virtual Webinar Series

Pharmaceutics, 2022-05, Vol.14 (5), p.1010

2022

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Discovery of 1‑Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)‑pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

Journal of medicinal chemistry, 2014-08, Vol.57 (15), p.6495-6512

2014

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From preclinical to human - prediction of oral absorption and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial setting: a workflow by using case example

Biopharmaceutics & drug disposition, 2012-03, Vol.33 (2), p.111-121

2012

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Activation of α7 nicotinic receptors improves phencyclidine-induced deficits in cognitive tasks in rats: Implications for therapy of cognitive dysfunction in schizophrenia

European neuropsychopharmacology, 2011-04, Vol.21 (4), p.333-343

2011

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Anxiolytic- and antidepressant-like profile of a new CRF1 receptor antagonist, R278995/CRA0450

European journal of pharmacology, 2004-02, Vol.485 (1-3), p.145-158

2004

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Physiologically based approaches towards the prediction of pharmacokinetics: in vitro-in vivo extrapolation

Expert opinion on drug metabolism & toxicology, 2007-12, Vol.3 (6), p.865-878

2007

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A toolbox for mimicking gastrointestinal conditions in children: Design and evaluation of biorelevant dissolution media for mimicking paediatric gastric- and small intestinal conditions

European journal of pharmaceutics and biopharmaceutics, 2023-12, Vol.193, p.144-157

2023

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The Power Hour of Writing: An empirical evaluation of our online writing community

Journal of academic writing, 2023-07, Vol.13 (1), p.22-34

2023

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Predicting Oral Clearance in Humans: How Close Can We Get with Allometry?

Clinical pharmacokinetics, 2008, Vol.47 (1), p.35-45

2008

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In vivo, in vitro and in silico methods for small molecule transfer across the BBB

Journal of pharmaceutical sciences, 2009-12, Vol.98 (12), p.4429-4468

2009

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Towards a Better Prediction of Peak Concentration, Volume of Distribution and Half-Life after Oral Drug Administration in Man, Using Allometry

Clinical pharmacokinetics, 2011-05, Vol.50 (5), p.307-318

2011

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Prediction of Human Oral Plasma Concentration-Time Profiles Using Preclinical Data

Clinical pharmacokinetics, 2011-08, Vol.50 (8), p.505

2011

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A Toolbox for Mimicking Gastrointestinal Conditions in Children: Simulated Paediatric Breakfast Media (SPBM) for Addressing the Variability of Gastric Contents After Typical Paediatric Breakfasts

Journal of pharmaceutical sciences, 2022-01, Vol.111 (1), p.51-61

2022

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Physiologically Based Biopharmaceutics Modeling (PBBM): Best Practices for Drug Product Quality, Regulatory and Industry Perspectives: 2023 Workshop Summary Report

Molecular pharmaceutics, 2024-05, Vol.21 (5), p.2065-2080

2024

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MetaSite: Understanding Metabolism in Human Cytochromes from the Perspective of the Chemist

Journal of medicinal chemistry, 2005-11, Vol.48 (22), p.6970-6979

2005

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Characterisation of fasted state gastric and intestinal fluids collected from children

European journal of pharmaceutics and biopharmaceutics, 2021-01, Vol.158, p.156-165

2021

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Evaluation of various PAMPA models to identify the most discriminating method for the prediction of BBB permeability

European journal of pharmaceutics and biopharmaceutics, 2010-03, Vol.74 (3), p.495-502

2010

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Cardio-vascular safety beyond hERG: in silico modelling of a guinea pig right atrium assay

Journal of computer-aided molecular design, 2009-12, Vol.23 (12), p.883-895

2009

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Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs

Developing Clinically Relevant Dissolution Specifications for Oral Drug Products-Industrial and Regulatory Perspectives

Discovery of 3‑Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3‑a]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

Discovery of 8‑Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3‑a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM)

The prediction of drug metabolism, tissue distribution, and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools

Novel generic UPLC/MS/MS method for high throughput analysis applied to permeability assessment in early Drug Discovery

Developing Clinically Relevant Dissolution Specifications (CRDSs) for Oral Drug Products: Virtual Webinar Series

Discovery of 1‑Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)‑pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

From preclinical to human - prediction of oral absorption and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial setting: a workflow by using case example

Activation of α7 nicotinic receptors improves phencyclidine-induced deficits in cognitive tasks in rats: Implications for therapy of cognitive dysfunction in schizophrenia

Anxiolytic- and antidepressant-like profile of a new CRF1 receptor antagonist, R278995/CRA0450

Physiologically based approaches towards the prediction of pharmacokinetics: in vitro-in vivo extrapolation

A toolbox for mimicking gastrointestinal conditions in children: Design and evaluation of biorelevant dissolution media for mimicking paediatric gastric- and small intestinal conditions

The Power Hour of Writing: An empirical evaluation of our online writing community

Predicting Oral Clearance in Humans: How Close Can We Get with Allometry?

In vivo, in vitro and in silico methods for small molecule transfer across the BBB

Towards a Better Prediction of Peak Concentration, Volume of Distribution and Half-Life after Oral Drug Administration in Man, Using Allometry

Prediction of Human Oral Plasma Concentration-Time Profiles Using Preclinical Data

A Toolbox for Mimicking Gastrointestinal Conditions in Children: Simulated Paediatric Breakfast Media (SPBM) for Addressing the Variability of Gastric Contents After Typical Paediatric Breakfasts

Physiologically Based Biopharmaceutics Modeling (PBBM): Best Practices for Drug Product Quality, Regulatory and Industry Perspectives: 2023 Workshop Summary Report

MetaSite: Understanding Metabolism in Human Cytochromes from the Perspective of the Chemist

Characterisation of fasted state gastric and intestinal fluids collected from children

Evaluation of various PAMPA models to identify the most discriminating method for the prediction of BBB permeability

Cardio-vascular safety beyond hERG: in silico modelling of a guinea pig right atrium assay

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