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A phenotypic screen with Trypanosoma brucei for discovering small molecules that target the SLiM‐binding pocket of proliferating cell nuclear antigen orthologs

Chemical biology & drug design, 2024-01, Vol.103 (1), p.e14361-n/a

2024

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Early invasion of brain parenchyma by African trypanosomes

PloS one, 2012-08, Vol.7 (8), p.e43913-e43913

2012

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CRIg plays an essential role in intravascular clearance of bloodborne parasites by interacting with complement

Proceedings of the National Academy of Sciences - PNAS, 2019-11, Vol.116 (48), p.24214-24220

2019

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Depletion of the extracellular-signal regulated kinase 8 homolog in Trypanosoma brucei in vivo reduces its virulence in a mouse target validation study

Molecular and biochemical parasitology, 2018-03, Vol.220, p.1-4

2018

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Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei

PLoS neglected tropical diseases, 2010-06, Vol.4 (6), p.e701-e701

2010

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RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model

PLoS neglected tropical diseases, 2008-09, Vol.2 (9), p.e298-e298

2008

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Extracellular-signal regulated kinase 8 of Trypanosoma brucei uniquely phosphorylates its proliferating cell nuclear antigen homolog and reveals exploitable properties

Cell cycle (Georgetown, Tex.), 2016-10, Vol.15 (20), p.2827-2841

2016

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Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor

Bioorganic & medicinal chemistry, 2016-10, Vol.24 (19), p.4647-4651

2016

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Deviating the level of proliferating cell nuclear antigen in Trypanosoma brucei elicits distinct mechanisms for inhibiting proliferation and cell cycle progression

Cell cycle (Georgetown, Tex.), 2015-02, Vol.14 (4), p.674-688

2015

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Examination of the Mode of Action of the Almiramide Family of Natural Products against the Kinetoplastid Parasite Trypanosoma brucei

Journal of natural products (Washington, D.C.), 2013-04, Vol.76 (4), p.630-641

2013

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Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit

PLoS neglected tropical diseases, 2009, Vol.3 (2), p.e372

2009

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A Cysteine Protease Inhibitor Rescues Mice from a Lethal Cryptosporidium parvum Infection

Antimicrobial Agents and Chemotherapy, 2013-12, Vol.57 (12), p.6063-6073

2013

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A Parasite Cysteine Protease Is Key to Host Protein Degradation and Iron Acquisition

The Journal of biological chemistry, 2008-10, Vol.283 (43), p.28934-28943

2008

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High-Throughput Analysis of an RNAi Library Identifies Novel Kinase Targets in Trypanosoma brucei

Chemical biology & drug design, 2011-09, Vol.78 (3), p.454-463

2011

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Synthesis and Structure−Activity Relationships of Parasiticidal Thiosemicarbazone Cysteine Protease Inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi

Journal of medicinal chemistry, 2004-06, Vol.47 (12), p.3212-3219

2004

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Mining a cathepsin inhibitor library for new antiparasitic drug leads

PLoS neglected tropical diseases, 2011-05, Vol.5 (5), p.e1023-e1023

2011

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A Cathepsin B-like Protease Is Required for Host Protein Degradation in Trypanosoma brucei

The Journal of biological chemistry, 2004-11, Vol.279 (46), p.48426-48433

2004

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Drugs targeting parasite lysosomes

Current pharmaceutical design, 2008-03, Vol.14 (9), p.889-900

2008

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Physical and Functional Interaction between DNA Ligase IIIα and Poly(ADP-Ribose) Polymerase 1 in DNA Single-Strand Break Repair

Molecular and Cellular Biology, 2003-08, Vol.23 (16), p.5919-5927

2003

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Discovery of Trypanocidal Compounds by Whole Cell HTS of Trypanosoma brucei

Chemical biology & drug design, 2006-05, Vol.67 (5), p.355-363

2006

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Isolation and identification of two novel SDS-resistant secreted chitinases from Aeromonas schubertii

Biotechnology progress, 2009-01, Vol.25 (1), p.124-131

2009

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Utility of CD117 immunoreactivity in differentiating metastatic melanoma from clear cell sarcoma

Archives of pathology & laboratory medicine (1976), 2006-03, Vol.130 (3), p.343-348

2006

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Antitrypanosomal Activity of 5‘-Deoxy-5‘-(iodomethylene)adenosine and Related 6-N-Cyclopropyladenosine Analogues

Journal of medicinal chemistry, 2006-03, Vol.49 (6), p.2096-2102

2006

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Evaluation of Cryptolepine and Huperzine Derivatives as Lead Compounds towards New Agents for the Treatment of Human African Trypanosomiasis

Natural product communications, 2009-02, Vol.4 (2), p.193-198

2009

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Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives

Bioorganic & medicinal chemistry letters, 2012-10, Vol.22 (19), p.6256-6260

2012

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A phenotypic screen with Trypanosoma brucei for discovering small molecules that target the SLiM‐binding pocket of proliferating cell nuclear antigen orthologs

Early invasion of brain parenchyma by African trypanosomes

CRIg plays an essential role in intravascular clearance of bloodborne parasites by interacting with complement

Depletion of the extracellular-signal regulated kinase 8 homolog in Trypanosoma brucei in vivo reduces its virulence in a mouse target validation study

Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei

RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model

Extracellular-signal regulated kinase 8 of Trypanosoma brucei uniquely phosphorylates its proliferating cell nuclear antigen homolog and reveals exploitable properties

Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor

Deviating the level of proliferating cell nuclear antigen in Trypanosoma brucei elicits distinct mechanisms for inhibiting proliferation and cell cycle progression

Examination of the Mode of Action of the Almiramide Family of Natural Products against the Kinetoplastid Parasite Trypanosoma brucei

Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit

A Cysteine Protease Inhibitor Rescues Mice from a Lethal Cryptosporidium parvum Infection

A Parasite Cysteine Protease Is Key to Host Protein Degradation and Iron Acquisition

High-Throughput Analysis of an RNAi Library Identifies Novel Kinase Targets in Trypanosoma brucei

Synthesis and Structure−Activity Relationships of Parasiticidal Thiosemicarbazone Cysteine Protease Inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi

Mining a cathepsin inhibitor library for new antiparasitic drug leads

A Cathepsin B-like Protease Is Required for Host Protein Degradation in Trypanosoma brucei

Drugs targeting parasite lysosomes

Physical and Functional Interaction between DNA Ligase IIIα and Poly(ADP-Ribose) Polymerase 1 in DNA Single-Strand Break Repair

Discovery of Trypanocidal Compounds by Whole Cell HTS of Trypanosoma brucei

Isolation and identification of two novel SDS-resistant secreted chitinases from Aeromonas schubertii

Utility of CD117 immunoreactivity in differentiating metastatic melanoma from clear cell sarcoma

Antitrypanosomal Activity of 5‘-Deoxy-5‘-(iodomethylene)adenosine and Related 6-N-Cyclopropyladenosine Analogues

Evaluation of Cryptolepine and Huperzine Derivatives as Lead Compounds towards New Agents for the Treatment of Human African Trypanosomiasis

Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives

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