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Can Allostery Be a Key Strategy for Targeting PTP1B in Drug Discovery? A Lesson from Trodusquemine

International journal of molecular sciences, 2023-06, Vol.24 (11), p.9621

2023

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In Search for Multi-Target Ligands as Potential Agents for Diabetes Mellitus and Its Complications-A Structure-Activity Relationship Study on Inhibitors of Aldose Reductase and Protein Tyrosine Phosphatase 1B

Molecules (Basel, Switzerland), 2021-01, Vol.26 (2), p.330

2021

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In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.200-203

2011

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In vitro antiproliferative activity against human colon cancer cell lines of representative 4-thiazolidinones. Part I

Bioorganic & medicinal chemistry letters, 2005-09, Vol.15 (17), p.3930-3933

2005

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Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives

Bioorganic & medicinal chemistry, 2008-06, Vol.16 (11), p.5840-5852

2008

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Identification of new non-carboxylic acid containing inhibitors of aldose reductase

Bioorganic & medicinal chemistry, 2010-06, Vol.18 (11), p.4049-4055

2010

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Sodium-Glucose Cotransporter Inhibitors as Antidiabetic Drugs: Current Development and Future Perspectives

Journal of medicinal chemistry, 2022-08, Vol.65 (16), p.10848-10881

2022

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The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices

TheScientificWorld, 2014-01, Vol.2014 (2014), p.1-8

2014

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Evaluation of in vitro aldose redutase inhibitory activity of 5-arylidene-2,4-thiazolidinediones

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3886-3893

2007

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5-Arylidene-4-thiazolidinone derivatives active as antidegenerative agents on human chondrocyte cultures

Medicinal chemistry (Shp-sariqah, United Arab Emirates), 2013-02, Vol.9 (1), p.84-90

2013

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In Vitro Antimycobacterial Activities of 2′-Monosubstituted Isonicotinohydrazides and Their Cyanoborane Adducts

Antimicrobial Agents and Chemotherapy, 2002-02, Vol.46 (2), p.294-299

2002

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Extending the investigation of 4-thiazolidinone derivatives as potential multi-target ligands of enzymes involved in diabetes mellitus and its long-term complications: A study with pancreatic α-amylase

Carbohydrate research, 2021-01, Vol.499, p.108220-108220, Article 108220

2021

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An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications

Bioorganic & medicinal chemistry letters, 2018-12, Vol.28 (23-24), p.3712-3720

2018

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Modeling and biological evaluation of 3,3′-(1,2-ethanediyl)bis[2-(4-methoxyphenyl)-thiazolidin-4-one], a new synthetic cyclooxygenase-2 inhibitor

European journal of pharmacology, 2002-07, Vol.448 (1), p.71-80

2002

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Protein-Tyrosine Phosphatase-1B Mediates Sleep Fragmentation-Induced Insulin Resistance and Visceral Adipose Tissue Inflammation in Mice

Sleep (New York, N.Y.), 2017-09, Vol.40 (9)

2017

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Designed multiple ligands for the treatment of type 2 diabetes mellitus and its complications: Discovery of (5-arylidene-4-oxo-2-thioxothiazolidin-3-yl)alkanoic acids active as novel dual-targeted PTP1B/AKR1B1 inhibitors

European journal of medicinal chemistry, 2023-04, Vol.252, p.115270-115270, Article 115270

2023

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Low Molecular Weight Phosphotyrosine Protein Phosphatases as Emerging Targets for the Design of Novel Therapeutic Agents

Journal of medicinal chemistry, 2012-01, Vol.55 (1), p.2-22

2012

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Structure–activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents

European journal of medicinal chemistry, 2014-06, Vol.81, p.1-14

2014

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Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B: In silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents

European journal of medicinal chemistry, 2017-02, Vol.127, p.840-858

2017

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Design and evaluation of non-carboxylate 5-arylidene-2-thioxo-4-imidazolidinones as novel non-competitive inhibitors of protein tyrosine phosphatase 1B

Bioorganic chemistry, 2019-11, Vol.92, p.103211-103211, Article 103211

2019

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Synthesis, biological activity and structure–activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells

European journal of medicinal chemistry, 2014-01, Vol.71, p.112-127

2014

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5-Arylidene-2-imino-4-thiazolidinones: Design and synthesis of novel anti-inflammatory agents

Bioorganic & medicinal chemistry, 2005-07, Vol.13 (13), p.4243-4252

2005

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Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications

European journal of medicinal chemistry, 2011-07, Vol.46 (7), p.2797-2806

2011

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In vitro advanced antimycobacterial screening of isoniazid-related hydrazones, hydrazides and cyanoboranes: Part 14

Bioorganic & medicinal chemistry letters, 2005-05, Vol.15 (10), p.2509-2513

2005

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5-Arylidene-2-phenylimino-4-thiazolidinones as PTP1B and LMW-PTP inhibitors

Bioorganic & medicinal chemistry, 2009-03, Vol.17 (5), p.1928-1937

2009

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Can Allostery Be a Key Strategy for Targeting PTP1B in Drug Discovery? A Lesson from Trodusquemine

In Search for Multi-Target Ligands as Potential Agents for Diabetes Mellitus and Its Complications-A Structure-Activity Relationship Study on Inhibitors of Aldose Reductase and Protein Tyrosine Phosphatase 1B

In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors

In vitro antiproliferative activity against human colon cancer cell lines of representative 4-thiazolidinones. Part I

Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives

Identification of new non-carboxylic acid containing inhibitors of aldose reductase

Sodium-Glucose Cotransporter Inhibitors as Antidiabetic Drugs: Current Development and Future Perspectives

The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices

Evaluation of in vitro aldose redutase inhibitory activity of 5-arylidene-2,4-thiazolidinediones

5-Arylidene-4-thiazolidinone derivatives active as antidegenerative agents on human chondrocyte cultures

In Vitro Antimycobacterial Activities of 2′-Monosubstituted Isonicotinohydrazides and Their Cyanoborane Adducts

Extending the investigation of 4-thiazolidinone derivatives as potential multi-target ligands of enzymes involved in diabetes mellitus and its long-term complications: A study with pancreatic α-amylase

An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications

Modeling and biological evaluation of 3,3′-(1,2-ethanediyl)bis[2-(4-methoxyphenyl)-thiazolidin-4-one], a new synthetic cyclooxygenase-2 inhibitor

Protein-Tyrosine Phosphatase-1B Mediates Sleep Fragmentation-Induced Insulin Resistance and Visceral Adipose Tissue Inflammation in Mice

Designed multiple ligands for the treatment of type 2 diabetes mellitus and its complications: Discovery of (5-arylidene-4-oxo-2-thioxothiazolidin-3-yl)alkanoic acids active as novel dual-targeted PTP1B/AKR1B1 inhibitors

Low Molecular Weight Phosphotyrosine Protein Phosphatases as Emerging Targets for the Design of Novel Therapeutic Agents

Structure–activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents

Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B: In silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents

Design and evaluation of non-carboxylate 5-arylidene-2-thioxo-4-imidazolidinones as novel non-competitive inhibitors of protein tyrosine phosphatase 1B

Synthesis, biological activity and structure–activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells

5-Arylidene-2-imino-4-thiazolidinones: Design and synthesis of novel anti-inflammatory agents

Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications

In vitro advanced antimycobacterial screening of isoniazid-related hydrazones, hydrazides and cyanoboranes: Part 14

5-Arylidene-2-phenylimino-4-thiazolidinones as PTP1B and LMW-PTP inhibitors

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