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Therapeutic Targeting of the IGF Axis

Cells (Basel, Switzerland), 2019-08, Vol.8 (8), p.895

2019

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Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation

Cancer cell, 2015-11, Vol.28 (5), p.557-568

2015

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Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination Studies

Targeted oncology, 2017-10, Vol.12 (5), p.571-597

2017

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Bad to the Bone: The Role of the Insulin-Like Growth Factor Axis in Osseous Metastasis

Clinical cancer research, 2019-06, Vol.25 (12), p.3479-3485

2019

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The Type 1 Insulin-Like Growth Factor Receptor Pathway

Clinical cancer research, 2008-10, Vol.14 (20), p.6364-6370

2008

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Type 1 Insulin-like Growth Factor Receptor Translocates to the Nucleus of Human Tumor Cells

Cancer research (Chicago, Ill.), 2010-08, Vol.70 (16), p.6412-6419

2010

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RAPTOR up-regulation contributes to resistance of renal cancer cells to PI3K-mTOR inhibition

PloS one, 2018-02, Vol.13 (2), p.e0191890-e0191890

2018

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Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

The Journal of pathology, 2011-09, Vol.225 (1), p.4-11

2011

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Can we unlock the potential of IGF-1R inhibition in cancer therapy?

Cancer treatment reviews, 2014-10, Vol.40 (9), p.1096-1105

2014

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Depletion of the type 1 IGF receptor delays repair of radiation-induced DNA double strand breaks

Radiotherapy and oncology, 2012-06, Vol.103 (3), p.402-409

2012

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The Efficacy of Small Interfering RNAs Targeted to the Type 1 Insulin-like Growth Factor Receptor (IGF1R) Is Influenced by Secondary Structure in the IGF1R Transcript

The Journal of biological chemistry, 2003-05, Vol.278 (18), p.15991-15997

2003

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Dsh homolog DVL3 mediates resistance to IGFIR inhibition by regulating IGF-RAS signaling

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (20), p.5866-5877

2014

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Insulin-Like Growth Factor 1 Regulates the Location, Stability, and Transcriptional Activity of β -Catenin

Proceedings of the National Academy of Sciences - PNAS, 2000-10, Vol.97 (22), p.12103-12108

2000

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Obesity: a perfect storm for carcinogenesis

Cancer and metastasis reviews, 2022-09, Vol.41 (3), p.491-515

2022

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Type 1 IGF receptor associates with adverse outcome and cellular radioresistance in paediatric high-grade glioma

British journal of cancer, 2020-03, Vol.122 (5), p.624-629

2020

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A Phase Ib/II study of IGF-neutralising antibody xentuzumab with enzalutamide in metastatic castration-resistant prostate cancer

British journal of cancer, 2023-10, Vol.129 (6), p.965-973

2023

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Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor Stage

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13), p.3497-3509

2018

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Validation of the type 1 insulin-like growth factor receptor as a therapeutic target in renal cancer

Molecular cancer therapeutics, 2009-06, Vol.8 (6), p.1448-1459

2009

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IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer

British journal of cancer, 2017-11, Vol.117 (11), p.1600-1606

2017

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CHK1 inhibition exacerbates replication stress induced by IGF blockade

Oncogene, 2022-01, Vol.41 (4), p.476-488

2022

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Targeting IGF Perturbs Global Replication through Ribonucleotide Reductase Dysfunction

Cancer research (Chicago, Ill.), 2021-04, Vol.81 (8), p.2128-2141

2021

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Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors

Clinical cancer research, 2016-06, Vol.22 (12), p.2897-2907

2016

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Suppression of homologous recombination sensitizes human tumor cells to IGF‐1R inhibition

International journal of cancer, 2015-06, Vol.136 (12), p.2961-2966

2015

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IGF-1R nuclear import and recruitment to chromatin involves both alpha and beta subunits

Discover. Oncology, 2021-12, Vol.12 (1), p.13-13, Article 13

2021

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Synthesis and bioactivity of fused- and spiro-β-lactone-lactam systems

Organic & biomolecular chemistry, 2017-06, Vol.15 (25), p.5373-5379

2017

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Therapeutic Targeting of the IGF Axis

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation

Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination Studies

Bad to the Bone: The Role of the Insulin-Like Growth Factor Axis in Osseous Metastasis

The Type 1 Insulin-Like Growth Factor Receptor Pathway

Type 1 Insulin-like Growth Factor Receptor Translocates to the Nucleus of Human Tumor Cells

RAPTOR up-regulation contributes to resistance of renal cancer cells to PI3K-mTOR inhibition

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

Can we unlock the potential of IGF-1R inhibition in cancer therapy?

Depletion of the type 1 IGF receptor delays repair of radiation-induced DNA double strand breaks

The Efficacy of Small Interfering RNAs Targeted to the Type 1 Insulin-like Growth Factor Receptor (IGF1R) Is Influenced by Secondary Structure in the IGF1R Transcript

Dsh homolog DVL3 mediates resistance to IGFIR inhibition by regulating IGF-RAS signaling

Insulin-Like Growth Factor 1 Regulates the Location, Stability, and Transcriptional Activity of β -Catenin

Obesity: a perfect storm for carcinogenesis

Type 1 IGF receptor associates with adverse outcome and cellular radioresistance in paediatric high-grade glioma

A Phase Ib/II study of IGF-neutralising antibody xentuzumab with enzalutamide in metastatic castration-resistant prostate cancer

Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor Stage

Validation of the type 1 insulin-like growth factor receptor as a therapeutic target in renal cancer

IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer

CHK1 inhibition exacerbates replication stress induced by IGF blockade

Targeting IGF Perturbs Global Replication through Ribonucleotide Reductase Dysfunction

Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors

Suppression of homologous recombination sensitizes human tumor cells to IGF‐1R inhibition

IGF-1R nuclear import and recruitment to chromatin involves both alpha and beta subunits

Synthesis and bioactivity of fused- and spiro-β-lactone-lactam systems

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