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IGF1R signalling and its inhibition

Endocrine-related cancer, 2006-12, Vol.13 (Supplement_1), p.S33-S43

2006

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Phase I study of humanized monoclonal antibody AVE1642 directed against the type 1 insulin-like growth factor receptor (IGF-1R), administered in combination with anticancer therapies to patients with advanced solid tumors

Annals of oncology, 2013-03, Vol.24 (3), p.784-791

2013

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The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma

Oncogene, 2007-10, Vol.26 (45), p.6499-6508

2007

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Fatal case of sorafenib-associated idiosyncratic hepatotoxicity in the adjuvant treatment of a patient with renal cell carcinoma

BMC cancer, 2012-12, Vol.12 (1), p.590-590, Article 590

2012

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Silencing of the Insulin Receptor Isoform A Favors Formation of Type 1 Insulin-Like Growth Factor Receptor (IGF-IR) Homodimers and Enhances Ligand-Induced IGF-IR Activation and Viability of Human Colon Carcinoma Cells

Endocrinology (Philadelphia), 2010-04, Vol.151 (4), p.1418-1427

2010

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Human melanoma cells expressing V600E B-RAF are susceptible to IGF1R targeting by small interfering RNAs

Oncogene, 2006-10, Vol.25 (50), p.6574-6581

2006

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Insulin-like growth factors and cancer

British journal of cancer, 1992-03, Vol.65 (3), p.311-320

MACAULAY, V. M

1992

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IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination

Oncogene, 2014-11, Vol.33 (45), p.5262-5273

2014

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Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase

Oncogene, 2001-07, Vol.20 (30), p.4029-4040

2001

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Chemosensitization of human prostate cancer using antisense agents targeting the type 1 insulin‐like growth factor receptor

BJU international, 2003-02, Vol.91 (3), p.271-277

2003

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The insulin-like growth factor system as a therapeutic target in colorectal cancer

Annals of oncology, 2002-03, Vol.13 (3), p.349-356

2002

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Phase I Study of Intrapleural Batimastat (BB-94), a Matrix Metalloproteinase Inhibitor, in the Treatment of Malignant Pleural Effusions

Clinical cancer research, 1999-03, Vol.5 (3), p.513-520

1999

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The Efficacy of Small Interfering RNAs Targeted to the Type 1 Insulin-like Growth Factor Receptor (IGF1R) Is Influenced by Secondary Structure in the IGF1R Transcript

The Journal of biological chemistry, 2003-05, Vol.278 (18), p.15991-15997

2003

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Development of Molecular Agents for IGF Receptor Targeting

Hormone and metabolic research, 2003-11, Vol.35 (11/12), p.843-849

2003

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Insulin-Like Growth Factor 1 Regulates the Location, Stability, and Transcriptional Activity of β -Catenin

Proceedings of the National Academy of Sciences - PNAS, 2000-10, Vol.97 (22), p.12103-12108

2000

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Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer

Cancer gene therapy, 2005-01, Vol.12 (1), p.90-100

2005

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The control and biological importance of intratumoural aromatase in breast cancer

Journal of steroid biochemistry and molecular biology, 1996, Vol.56 (1), p.145-150

1996

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Proteolytic modification of insulin-like growth factor-binding proteins: comparison of conditioned media from human cell lines, circulating proteases and characterized enzymes

Journal of endocrinology, 1993-09, Vol.138 (3), p.545

1993

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Experimental and clinical studies with somatostatin analogue octreotide in small cell lung cancer

British journal of cancer, 1991-09, Vol.64 (3), p.451-456

1991

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Biological effects of stable overexpression of aromatase in human hormone-dependent breast cancer cells

British journal of cancer, 1994-01, Vol.69 (1), p.77-83

1994

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IGF-1R expression is associated with HPV-negative status and adverse survival in head and neck squamous cell cancer

Carcinogenesis (New York), 2015-06, Vol.36 (6), p.648-655

2015

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Phase I study of the mitomycin C analogue BMS-181174

British journal of cancer, 1998-06, Vol.77 (11), p.2020-2027

1998

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Modulation of bryostatin 1 muscle toxicity by nifedipine: effects on muscle metabolism and oxygen supply

British journal of cancer, 1996-05, Vol.73 (10), p.1161-1165

1996

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Autocrine function for insulin-like growth factor I in human small cell lung cancer cell lines and fresh tumor cells

Cancer research (Chicago, Ill.), 1990-04, Vol.50 (8), p.2511-2517

1990

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Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease

Cancer research (Chicago, Ill.), 2002-05, Vol.62 (10), p.2942-2950

2002

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IGF1R signalling and its inhibition

Phase I study of humanized monoclonal antibody AVE1642 directed against the type 1 insulin-like growth factor receptor (IGF-1R), administered in combination with anticancer therapies to patients with advanced solid tumors

The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma

Fatal case of sorafenib-associated idiosyncratic hepatotoxicity in the adjuvant treatment of a patient with renal cell carcinoma

Silencing of the Insulin Receptor Isoform A Favors Formation of Type 1 Insulin-Like Growth Factor Receptor (IGF-IR) Homodimers and Enhances Ligand-Induced IGF-IR Activation and Viability of Human Colon Carcinoma Cells

Human melanoma cells expressing V600E B-RAF are susceptible to IGF1R targeting by small interfering RNAs

Insulin-like growth factors and cancer

IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination

Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase

Chemosensitization of human prostate cancer using antisense agents targeting the type 1 insulin‐like growth factor receptor

The insulin-like growth factor system as a therapeutic target in colorectal cancer

Phase I Study of Intrapleural Batimastat (BB-94), a Matrix Metalloproteinase Inhibitor, in the Treatment of Malignant Pleural Effusions

The Efficacy of Small Interfering RNAs Targeted to the Type 1 Insulin-like Growth Factor Receptor (IGF1R) Is Influenced by Secondary Structure in the IGF1R Transcript

Development of Molecular Agents for IGF Receptor Targeting

Insulin-Like Growth Factor 1 Regulates the Location, Stability, and Transcriptional Activity of β -Catenin

Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer

The control and biological importance of intratumoural aromatase in breast cancer

Proteolytic modification of insulin-like growth factor-binding proteins: comparison of conditioned media from human cell lines, circulating proteases and characterized enzymes

Experimental and clinical studies with somatostatin analogue octreotide in small cell lung cancer

Biological effects of stable overexpression of aromatase in human hormone-dependent breast cancer cells

IGF-1R expression is associated with HPV-negative status and adverse survival in head and neck squamous cell cancer

Phase I study of the mitomycin C analogue BMS-181174

Modulation of bryostatin 1 muscle toxicity by nifedipine: effects on muscle metabolism and oxygen supply

Autocrine function for insulin-like growth factor I in human small cell lung cancer cell lines and fresh tumor cells

Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease

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