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Functional signaling test identifies HER2 negative breast cancer patients who may benefit from c-Met and pan-HER combination therapy

Cell communication and signaling, 2022-01, Vol.20 (1), p.4-4, Article 4

2022

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Genetically Modified Bacterial Strains and Novel Bacterial Artificial Chromosome Shuttle Vectors for Constructing Environmental Libraries and Detecting Heterologous Natural Products in Multiple Expression Hosts

Applied and Environmental Microbiology, 2004-04, Vol.70 (4), p.2452-2463

2004

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New HER2-negative breast cancer subtype responsive to anti-HER2 therapy identified

Journal of cancer research and clinical oncology, 2020-03, Vol.146 (3), p.605-619

2020

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Development of a test that measures real-time HER2 signaling function in live breast cancer cell lines and primary cells

BMC cancer, 2017-03, Vol.17 (1), p.199-199, Article 199

2017

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Cloning the Soil Metagenome: a Strategy for Accessing the Genetic and Functional Diversity of Uncultured Microorganisms

Applied and Environmental Microbiology, 2000-06, Vol.66 (6), p.2541-2547

2000

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A functional signal profiling test for identifying a subset of HER2-negative breast cancers with abnormally amplified HER2 signaling activity

Oncotarget, 2016-11, Vol.7 (48), p.78577-78590

2016

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Discovery of Potent and Selective SH2 Inhibitors of the Tyrosine Kinase ZAP-70

Journal of medicinal chemistry, 1999-10, Vol.42 (20), p.4088-4098

1999

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Therapeutic effect of gedatolisib, a pan-PI3K/mTOR inhibitor, on prostate cancer models with PI3K or PTEN mutational status

Journal of clinical oncology, 2023-02, Vol.41 (6_suppl), p.149-149

2023

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Test measuring signaling activity in live patient tumor cells to identify PI3KCA WT patients who may benefit from PI3K inhibitors

Journal of clinical oncology, 2020-05, Vol.38 (15_suppl), p.e13000-e13000

2020

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Test identifies ovarian cancer patients with hyperactive c-Met and ErbB signaling tumors who may benefit from c-Met and pan-HER combination therapy

Journal of clinical oncology, 2020-05, Vol.38 (15_suppl), p.e18038-e18038

2020

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Changing Concepts of Contract: Essays in Honour of Ian Macneil

2017

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Live tumor cell functional analysis and a xenograft model find co-activated c-Met and ErbB signaling in HER2-negative breast cancer

Journal of clinical oncology, 2018-05, Vol.36 (15_suppl), p.e24292-e24292

2018

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Measuring functional HER2-driven signaling status ex vivo to predict response to HER2 therapy: Results from a mouse breast tumor xenograft study

Journal of clinical oncology, 2017-05, Vol.35 (15_suppl), p.e23203-e23203

2017

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Profiling of signaling pathways in live tumor cells to assess drug mechanism of action: A method to predict drug efficacy in a patient

Journal of clinical oncology, 2014-05, Vol.32 (15_suppl), p.e11583-e11583

2014

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Dynamic real-time signaling profiles of live primary cells to characterize the response of PI3K and MAPK pathways in HER2+ breast cancer cells to attenuation with lapatinib: Tests of reproducibility of method

Journal of clinical oncology, 2014-05, Vol.32 (15_suppl), p.e11597-e11597

2014

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IL-10, a novel growth cofactor for mature and immature T cells

The Journal of immunology (1950), 1990-12, Vol.145 (12), p.4167-4173

1990

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Protein tyrosine kinases Syk and ZAP-70 display distinct requirements for Src family kinases in immune response receptor signal transduction

The Journal of immunology (1950), 1997-02, Vol.158 (4), p.1650-1659

1997

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A Fluorescence Polarization Based Src-SH2 Binding Assay

Analytical biochemistry, 1997-04, Vol.247 (1), p.77-82

1997

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Cloning, Baculovirus Expression, and Characterization of a Second Mouse Prolyl 4-Hydroxylase α-Subunit Isoform: Formation of an α2β2Tetramer with the Protein Disulfide-Isomerase/β Subunit

Proceedings of the National Academy of Sciences - PNAS, 1995-05, Vol.92 (10), p.4427-4431

1995

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Structure-activity relationships of a novel class of Src SH2 inhibitors

Bioorganic & medicinal chemistry letters, 1999-08, Vol.9 (16), p.2359-2364

1999

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Simultaneous Assay of Src SH3 and SH2 Domain Binding Using Different Wavelength Fluorescence Polarization Probes

Analytical biochemistry, 1999-11, Vol.275 (1), p.62-73

1999

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Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: Formation of an alpha2beta2 tetramer with the protein disulfide-isomerase/beta subunit

Proceedings of the National Academy of Sciences - PNAS, 1995-05, Vol.92 (10), p.4427

1995

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Excision-amplification of mitochondrial DNA during senescence in Podospora anserina: DNA sequence analysis of three unique “plasmids”

Journal of molecular biology, 1985-10, Vol.185 (4), p.659-680

1985

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Financial Services and Markets Act 2000

The New Oxford Companion to Law, 2008

Ian MacNeil

1, 2008

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Financial Services Authority

The New Oxford Companion to Law, 2008

Ian MacNeil

1, 2008

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Functional signaling test identifies HER2 negative breast cancer patients who may benefit from c-Met and pan-HER combination therapy

Genetically Modified Bacterial Strains and Novel Bacterial Artificial Chromosome Shuttle Vectors for Constructing Environmental Libraries and Detecting Heterologous Natural Products in Multiple Expression Hosts

New HER2-negative breast cancer subtype responsive to anti-HER2 therapy identified

Development of a test that measures real-time HER2 signaling function in live breast cancer cell lines and primary cells

Cloning the Soil Metagenome: a Strategy for Accessing the Genetic and Functional Diversity of Uncultured Microorganisms

A functional signal profiling test for identifying a subset of HER2-negative breast cancers with abnormally amplified HER2 signaling activity

Discovery of Potent and Selective SH2 Inhibitors of the Tyrosine Kinase ZAP-70

Therapeutic effect of gedatolisib, a pan-PI3K/mTOR inhibitor, on prostate cancer models with PI3K or PTEN mutational status

Test measuring signaling activity in live patient tumor cells to identify PI3KCA WT patients who may benefit from PI3K inhibitors

Test identifies ovarian cancer patients with hyperactive c-Met and ErbB signaling tumors who may benefit from c-Met and pan-HER combination therapy

Changing Concepts of Contract: Essays in Honour of Ian Macneil

Live tumor cell functional analysis and a xenograft model find co-activated c-Met and ErbB signaling in HER2-negative breast cancer

Measuring functional HER2-driven signaling status ex vivo to predict response to HER2 therapy: Results from a mouse breast tumor xenograft study

Profiling of signaling pathways in live tumor cells to assess drug mechanism of action: A method to predict drug efficacy in a patient

Dynamic real-time signaling profiles of live primary cells to characterize the response of PI3K and MAPK pathways in HER2+ breast cancer cells to attenuation with lapatinib: Tests of reproducibility of method

IL-10, a novel growth cofactor for mature and immature T cells

Protein tyrosine kinases Syk and ZAP-70 display distinct requirements for Src family kinases in immune response receptor signal transduction

A Fluorescence Polarization Based Src-SH2 Binding Assay

Cloning, Baculovirus Expression, and Characterization of a Second Mouse Prolyl 4-Hydroxylase α-Subunit Isoform: Formation of an α2β2Tetramer with the Protein Disulfide-Isomerase/β Subunit

Structure-activity relationships of a novel class of Src SH2 inhibitors

Simultaneous Assay of Src SH3 and SH2 Domain Binding Using Different Wavelength Fluorescence Polarization Probes

Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: Formation of an alpha2beta2 tetramer with the protein disulfide-isomerase/beta subunit

Excision-amplification of mitochondrial DNA during senescence in Podospora anserina: DNA sequence analysis of three unique “plasmids”

Financial Services and Markets Act 2000

Financial Services Authority

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