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Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin‑2 Inducible T‑Cell Kinase (ITK) Inhibitors

Journal of medicinal chemistry, 2016-05, Vol.59 (9), p.4352-4363

2016

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Property- and Structure-Guided Discovery of a Tetrahydroindazole Series of Interleukin‑2 Inducible T‑Cell Kinase Inhibitors

Journal of medicinal chemistry, 2014-07, Vol.57 (13), p.5714-5727

2014

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Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK)

Bioorganic & medicinal chemistry letters, 2014-12, Vol.24 (24), p.5818-5823

2014

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Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK)

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (23), p.6331-6335

2013

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Potent agonists of the Hedgehog signaling pathway

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (15), p.4308-4311

2009

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Tandem Diels−Alder/Fragmentation Approach to the Synthesis of Eleutherobin

Organic letters, 2003-05, Vol.5 (10), p.1805-1808

2003

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HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (15), p.4480-4483

2009

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‘Chemical co-substrate rescue’ of phytanoyl-CoA 2-hydroxylase mutants causing Refsum’s Disease

Chemical communications (Cambridge, England), 2001-01 (11), p.972-973

2001

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Enzymatic Synthesis of Monocyclic β-Lactams

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (4), p.597-599

2002

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Studies on phytanoyl-CoA 2-hydroxylase and synthesis of phytanoyl-Coenzyme A

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (18), p.2545-2548

2001

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Cloning, expression, and purification of mammalian 4-hydroxyphenylpyruvate dioxygenase/α-ketoisocaproate dioxygenase

Methods in Enzymology, 2000, Vol.324, p.342-355

2000

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A mechanistic rationalisation for the substrate specificity of recombinant mammalian 4-hydroxyphenylpyruvate dioxygenase (4-HPPD)

Tetrahedron, 1997-05, Vol.53 (20), p.6993-7010

1997

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The C-terminal of rat 4-hydroxyphenylpyruvate dioxygenase is indispensable for enzyme activity

FEBS letters, 1996-09, Vol.393 (2), p.269-272

1996

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Identification and stereochemistry of the product of 4-HPPD catalyzed oxidation of the ketoacid of methionine

Bioorganic & medicinal chemistry letters, 1996-08, Vol.6 (16), p.2003-2006

1996

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Stereochemical course of the conversion of α-ketoisocaproate to β-hydroxyisovalerate by soluble, recombinant mammalian 4-hydroxyphenylpyruvate dioxygenase

Tetrahedron, 1997-08, Vol.53 (31), p.10827-10840

1997

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Stereochemistry of hydroxylation during the conversion of α-ketoisocaproate to β-hydroxyisovalerate by 4-hydroxyphenylpyruvate dioxygenase

Bioorganic & medicinal chemistry letters, 1996-11, Vol.6 (22), p.2721-2724

1996

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Tandem Diels-Alder/Fragmentation Approach to the Synthesis of Eleutherobin

ChemInform, 2003-09, Vol.34 (38), p.no-no

2003

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ChemInform Abstract: Enzymatic Synthesis of Monocyclic β-Lactams

ChemInform, 2002-05, Vol.33 (21), p.no-no

2002

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Pathologic, Immunologic, and Clinical Analysis of the Microsatellite Instability Phenotype in Endometrial Carcinoma

Human pathology, 2023-09, Vol.139, p.80-90

2023

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Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder

Psychological medicine, 2012-07, Vol.42 (7), p.1449-1459

2012

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Climate change implications in the northern coastal temperate rainforest of North America

Climatic change, 2015-05, Vol.130 (2), p.155-170

2015

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Adjuvant Trastuzumab in HER2-Positive Breast Cancer

The New England journal of medicine, 2011-10, Vol.365 (14), p.1273-1283

2011

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The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification

Kidney international, 2009-09, Vol.76 (5), p.534-545

2009

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The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility

Kidney international, 2009-09, Vol.76 (5), p.546-556

2009

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Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12

Molecular psychiatry, 2003-03, Vol.8 (3), p.288-298

2003

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Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin‑2 Inducible T‑Cell Kinase (ITK) Inhibitors

Property- and Structure-Guided Discovery of a Tetrahydroindazole Series of Interleukin‑2 Inducible T‑Cell Kinase Inhibitors

Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK)

Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK)

Potent agonists of the Hedgehog signaling pathway

Tandem Diels−Alder/Fragmentation Approach to the Synthesis of Eleutherobin

HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives

‘Chemical co-substrate rescue’ of phytanoyl-CoA 2-hydroxylase mutants causing Refsum’s Disease

Enzymatic Synthesis of Monocyclic β-Lactams

Studies on phytanoyl-CoA 2-hydroxylase and synthesis of phytanoyl-Coenzyme A

Cloning, expression, and purification of mammalian 4-hydroxyphenylpyruvate dioxygenase/α-ketoisocaproate dioxygenase

A mechanistic rationalisation for the substrate specificity of recombinant mammalian 4-hydroxyphenylpyruvate dioxygenase (4-HPPD)

The C-terminal of rat 4-hydroxyphenylpyruvate dioxygenase is indispensable for enzyme activity

Identification and stereochemistry of the product of 4-HPPD catalyzed oxidation of the ketoacid of methionine

Stereochemical course of the conversion of α-ketoisocaproate to β-hydroxyisovalerate by soluble, recombinant mammalian 4-hydroxyphenylpyruvate dioxygenase

Stereochemistry of hydroxylation during the conversion of α-ketoisocaproate to β-hydroxyisovalerate by 4-hydroxyphenylpyruvate dioxygenase

Tandem Diels-Alder/Fragmentation Approach to the Synthesis of Eleutherobin

ChemInform Abstract: Enzymatic Synthesis of Monocyclic β-Lactams

Pathologic, Immunologic, and Clinical Analysis of the Microsatellite Instability Phenotype in Endometrial Carcinoma

Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder

Climate change implications in the northern coastal temperate rainforest of North America

Adjuvant Trastuzumab in HER2-Positive Breast Cancer

The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification

The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility

Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12

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