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Mortality and quality of life in the five years after severe sepsis

Critical care (London, England), 2013-04, Vol.17 (2), p.R70-R70, Article R70

2013

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The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family

European journal of pharmacology, 2006-05, Vol.538 (1), p.39-42

2006

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Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A‐mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

British journal of pharmacology, 2002-06, Vol.136 (3), p.421-433

2002

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Increased Hospital-Based Physical Rehabilitation and Information Provision After Intensive Care Unit Discharge: The RECOVER Randomized Clinical Trial

JAMA internal medicine, 2015-06, Vol.175 (6), p.901

2015

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Measuring Hospital-Wide Mortality-Pitfalls and Potential

Journal for healthcare quality, 2016-05, Vol.38 (3), p.187-194

2016

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Sub‐family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP‐specific phosphodiesterases

British journal of pharmacology, 2000-10, Vol.131 (4), p.811-819

2000

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The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma

Respiratory research, 2004-05, Vol.5 (1), p.4-4, Article 4

2004

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C5a Mediates Peripheral Blood Neutrophil Dysfunction in Critically Ill Patients

American journal of respiratory and critical care medicine, 2009-07, Vol.180 (1), p.19-28

2009

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Diagnostic importance of pulmonary interleukin-1β and interleukin-8 in ventilator-associated pneumonia

Thorax, 2010-03, Vol.65 (3), p.201-207

2010

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Phosphodiesterase 4 cAMP phosphodiesterases as targets for novel anti-inflammatory therapeutics

Allergology international, 2004, Vol.53 (2), p.101-110

MacKenzie, Simon J

2004

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Rhodanine derivatives as novel inhibitors of PDE4

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.2032-2037

2008

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Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells

Biochemical journal, 2000-04, Vol.347 (Pt 2), p.571-578

2000

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The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579

The EMBO journal, 1999-02, Vol.18 (4), p.893-903

1999

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Stimulation of p70S6 Kinase via a Growth Hormone-Controlled Phosphatidylinositol 3-Kinase Pathway Leads to the Activation of a PDE4A Cyclic AMP-Specific Phosphodiesterase in 3T3-F442A Preadipocytes

Proceedings of the National Academy of Sciences - PNAS, 1998-03, Vol.95 (7), p.3549-3554

1998

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A rehabilitation intervention to promote physical recovery following intensive care: a detailed description of construct development, rationale and content together with proposed taxonomy to capture processes in a randomised controlled trial

Trials, 2014-01, Vol.15 (1), p.38-38, Article 38

2014

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Hyperlactatemia and Pulmonary Lactate Production in Patients With Fulminant Hepatic Failure

Chest, 1999-08, Vol.116 (2), p.471-476

1999

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A randomised controlled trial evaluating a rehabilitation complex intervention for patients following intensive care discharge: the RECOVER study

BMJ open, 2012-01, Vol.2 (4), p.e001475

2012

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2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: A new class of protein tyrosine phosphatase 1B inhibitors

Bioorganic & medicinal chemistry, 2007-12, Vol.17 (23), p.6579-6583

2007

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Phorbol 12-myristate 13-acetate Triggers the Protein Kinase A-Mediated Phosphorylation and Activation of the PDE4D5 cAMP Phosphodiesterase in Human Aortic Smooth Muscle Cells through a Route Involving Extracellular Signal Regulated Kinase (ERK)

Molecular pharmacology, 2001-11, Vol.60 (5), p.1100-1111

2001

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Glucocorticoid receptor α:β ratio in blood mononuclear cells is reduced in cigarette smokers

Journal of allergy and clinical immunology, 2004-12, Vol.114 (6), p.1475-1478

2004

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Protein kinase C isoforms play differential roles in the regulation of adipocyte differentiation

Biochemical journal, 1998-08, Vol.333 ( Pt 3) (3), p.719-727

1998

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Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells

Biochemical journal, 2000-04, Vol.347 (2), p.571-578

2000

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Patient and carer experience of hospital-based rehabilitation from intensive care to hospital discharge: mixed methods process evaluation of the RECOVER randomised clinical trial

BMJ open, 2016-07, Vol.6 (8), p.e012041-e012041

2016

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ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions

The Journal of biological chemistry, 2000-06, Vol.275 (22), p.16609-16617

2000

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ERK2 Mitogen-activated Protein Kinase Binding, Phosphorylation, and Regulation of the PDE4D cAMP-specific Phosphodiesterases

The Journal of biological chemistry, 2000-06, Vol.275 (22), p.16609-16617

2000

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Mortality and quality of life in the five years after severe sepsis

The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family

Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A‐mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

Increased Hospital-Based Physical Rehabilitation and Information Provision After Intensive Care Unit Discharge: The RECOVER Randomized Clinical Trial

Measuring Hospital-Wide Mortality-Pitfalls and Potential

Sub‐family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP‐specific phosphodiesterases

The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma

C5a Mediates Peripheral Blood Neutrophil Dysfunction in Critically Ill Patients

Diagnostic importance of pulmonary interleukin-1β and interleukin-8 in ventilator-associated pneumonia

Phosphodiesterase 4 cAMP phosphodiesterases as targets for novel anti-inflammatory therapeutics

Rhodanine derivatives as novel inhibitors of PDE4

Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells

The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579

Stimulation of p70S6 Kinase via a Growth Hormone-Controlled Phosphatidylinositol 3-Kinase Pathway Leads to the Activation of a PDE4A Cyclic AMP-Specific Phosphodiesterase in 3T3-F442A Preadipocytes

A rehabilitation intervention to promote physical recovery following intensive care: a detailed description of construct development, rationale and content together with proposed taxonomy to capture processes in a randomised controlled trial

Hyperlactatemia and Pulmonary Lactate Production in Patients With Fulminant Hepatic Failure

A randomised controlled trial evaluating a rehabilitation complex intervention for patients following intensive care discharge: the RECOVER study

2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: A new class of protein tyrosine phosphatase 1B inhibitors

Phorbol 12-myristate 13-acetate Triggers the Protein Kinase A-Mediated Phosphorylation and Activation of the PDE4D5 cAMP Phosphodiesterase in Human Aortic Smooth Muscle Cells through a Route Involving Extracellular Signal Regulated Kinase (ERK)

Glucocorticoid receptor α:β ratio in blood mononuclear cells is reduced in cigarette smokers

Protein kinase C isoforms play differential roles in the regulation of adipocyte differentiation

Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells

Patient and carer experience of hospital-based rehabilitation from intensive care to hospital discharge: mixed methods process evaluation of the RECOVER randomised clinical trial

ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions

ERK2 Mitogen-activated Protein Kinase Binding, Phosphorylation, and Regulation of the PDE4D cAMP-specific Phosphodiesterases

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