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MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways

Science translational medicine, 2012-02, Vol.4 (121), p.121ra18

2012

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Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways

The Journal of clinical investigation, 2015-01, Vol.125 (1), p.141-156

2015

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Let-7 Coordinately Suppresses Components of the Amino Acid Sensing Pathway to Repress mTORC1 and Induce Autophagy

Cell metabolism, 2014-10, Vol.20 (4), p.626-638

2014

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Lysyl oxidase like-2 contributes to renal fibrosis in Col4α3/Alport mice

Kidney international, 2018-08, Vol.94 (2), p.303-314

2018

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Identification of 4‑(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)

Journal of medicinal chemistry, 2017-05, Vol.60 (10), p.4403-4423

2017

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Polysome shift assay for direct measurement of miRNA inhibition by anti-miRNA drugs

Nucleic acids research, 2016-01, Vol.44 (2), p.e13-e13

2016

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Liver-targeted drug delivery using HepDirect prodrugs

The Journal of pharmacology and experimental therapeutics, 2005-02, Vol.312 (2), p.554-560

2005

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Fibronectin Matrix Regulates Activation of RHO and CDC42 GTPases and Cell Cycle Progression

The Journal of cell biology, 1998-10, Vol.143 (1), p.267-276

1998

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A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis

ACS medicinal chemistry letters, 2010-12, Vol.1 (9), p.478-482

2010

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Synthesis and Characterization of a Novel Liver-Targeted Prodrug of Cytosine-1-β-d-arabinofuranoside Monophosphate for the Treatment of Hepatocellular Carcinoma

Journal of medicinal chemistry, 2006-12, Vol.49 (26), p.7711-7720

2006

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Delivery of high levels of anti-proliferative nucleoside triphosphates to CYP3A-expressing cells as a potential treatment for hepatocellular carcinoma

Cancer chemotherapy and pharmacology, 2009-10, Vol.64 (5), p.981-991

2009

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Thyromimetics improve disease endpoints and modulate potential target engagement biomarkers in rodent models of ALD and MS (P3-4.011)

Neurology, 2022-05, Vol.98 (18_supplement)

2022

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Therapeutic modulation of microRNAs

Drug discovery today. Therapeutic strategies, 2013, Vol.10 (3), p.e127-e132

2013

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Dysregulated Expression of microRNA-21 and Disease-Related Genes in Human Patients and in a Mouse Model of Alport Syndrome

Human gene therapy, 2019-07, Vol.30 (7), p.865-881

2019

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ABX-002: A fatty-acid amide hydrolase (FAAH) activated prodrug enhances functional delivery of a potent TR-β selective thyromimetic to the brain and demonstrates biological activity in models of X-linked Adrenoleukodystrophy (2442)

Neurology, 2021-04, Vol.96 (15_supplement)

2021

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Lysyl oxidase like-2 contributes to renal fibrosis in Col4a3/Alport Mice

Kidney international, 2018-05, Vol.94 (2), p.303-314

2018

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Hit-to-Lead Optimization and Discovery of 5‑((5-([1,1′-Biphenyl]-4-yl)-6-chloro‑1H‑benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase

Journal of medicinal chemistry, 2017-11, Vol.60 (21), p.9040-9052

2017

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Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis

Cardiovascular research, 2000-05, Vol.46 (2), p.257-263

2000

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Microstructural model of perimysial collagen fibers for resting myocardial mechanics during ventricular filling

American journal of physiology. Heart and circulatory physiology, 1997-09, Vol.273 (3), p.H1576-H1586

1997

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Anti-microRNA21 as a strategy to treat progressive kidney disease (abstract)

Néphrologie & thérapeutique, 2016-04, Vol.12, p.S39-S39

2016

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Measurement of strain and analysis of stress in resting rat left ventricular myocardium

Journal of biomechanics, 1993-06, Vol.26 (6), p.665-676

1993

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Hit-to-Lead Optimization and Discovery of 5-((5-([1,1′-Biphenyl]-4-yl)-6-chloro-1 H -benzo[ d ]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase

Journal of medicinal chemistry, 2017-11, Vol.60 (21), p.9040-9052

2017

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Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts

The Journal of clinical investigation, 1998-01, Vol.101 (2), p.301-310

1998

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microRNAs in models of fibrosis

Drug discovery today. Disease models, 2013, Vol.10 (3), p.e111-e113

2013

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Immobilization of the knee joint alters the mechanical and ultrastructural properties of the rabbit anterior cruciate ligament

Journal of orthopaedic research, 1995-03, Vol.13 (2), p.191-200

1995

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MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways

Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways

Let-7 Coordinately Suppresses Components of the Amino Acid Sensing Pathway to Repress mTORC1 and Induce Autophagy

Lysyl oxidase like-2 contributes to renal fibrosis in Col4α3/Alport mice

Identification of 4‑(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)

Polysome shift assay for direct measurement of miRNA inhibition by anti-miRNA drugs

Liver-targeted drug delivery using HepDirect prodrugs

Fibronectin Matrix Regulates Activation of RHO and CDC42 GTPases and Cell Cycle Progression

A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis

Synthesis and Characterization of a Novel Liver-Targeted Prodrug of Cytosine-1-β-d-arabinofuranoside Monophosphate for the Treatment of Hepatocellular Carcinoma

Delivery of high levels of anti-proliferative nucleoside triphosphates to CYP3A-expressing cells as a potential treatment for hepatocellular carcinoma

Thyromimetics improve disease endpoints and modulate potential target engagement biomarkers in rodent models of ALD and MS (P3-4.011)

Therapeutic modulation of microRNAs

Dysregulated Expression of microRNA-21 and Disease-Related Genes in Human Patients and in a Mouse Model of Alport Syndrome

ABX-002: A fatty-acid amide hydrolase (FAAH) activated prodrug enhances functional delivery of a potent TR-β selective thyromimetic to the brain and demonstrates biological activity in models of X-linked Adrenoleukodystrophy (2442)

Lysyl oxidase like-2 contributes to renal fibrosis in Col4a3/Alport Mice

Hit-to-Lead Optimization and Discovery of 5‑((5-([1,1′-Biphenyl]-4-yl)-6-chloro‑1H‑benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase

Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis

Microstructural model of perimysial collagen fibers for resting myocardial mechanics during ventricular filling

Anti-microRNA21 as a strategy to treat progressive kidney disease (abstract)

Measurement of strain and analysis of stress in resting rat left ventricular myocardium

Hit-to-Lead Optimization and Discovery of 5-((5-([1,1′-Biphenyl]-4-yl)-6-chloro-1 H -benzo[ d ]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase

Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts

microRNAs in models of fibrosis

Immobilization of the knee joint alters the mechanical and ultrastructural properties of the rabbit anterior cruciate ligament

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