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The molecular mechanisms of drug action

QJM : An International Journal of Medicine, 1998-01, Vol.91 (1), p.1-3

MacDermot, J

1998

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Neuropathic pain in Anderson-Fabry disease: pathology and therapeutic options

European Journal of Pharmacology, 2001-10, Vol.429 (1), p.121-125

2001

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The N-terminal thrombin receptor fragment SFLLRN, but not catalytically inactive thrombin-derived agonists, activate U937 human monocytic cells : evidence for receptor hydrolysis in thrombin-dependent signalling

Biochemical journal, 1993-03, Vol.290 (2), p.571-577

1993

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Pyocyanin and 1-hydroxyphenazine produced by Pseudomonas aeruginosa inhibit the beating of human respiratory cilia in vitro

The Journal of clinical investigation, 1987, Vol.79 (1), p.221-229

1987

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Inhibition of chemotaxis in A7r5 rat smooth muscle cells by a novel panel of inhibitors

British journal of pharmacology, 1998-09, Vol.125 (1), p.152-158

1998

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Arginine-specific ADP-ribosyltransferases in leukocytes

Journal of leukocyte biology, 1998-01, Vol.63 (1), p.15-21

1998

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Thrombin promotes actin polymerization in U937 human monocyte-macrophage cells : analysis of the signalling mechanisms mediating actin polymerization

Biochemical journal, 1992-09, Vol.286 (3), p.945-950

1992

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Impairment of function in aging neutrophils is associated with apoptosis

The Journal of immunology (1950), 1993-06, Vol.150 (11), p.5124-5134

1993

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Reduction by inhibitors of mono(ADP‐ribosyl)transferase of chemotaxis in human neutrophil leucocytes by inhibition of the assembly of filamentous actin

British journal of pharmacology, 1996-07, Vol.118 (5), p.1111-1118

1996

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Human calcitonin gene‐related peptide activates adenylate cyclase and releases prostacyclin from human umbilical vein endothelial cells

British journal of pharmacology, 1987-12, Vol.92 (4), p.695-701

1987

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Differential sensitivities of the prostacyclin and nitric oxide biosynthetic pathways to cytosolic calcium in bovine aortic endothelial cells

British journal of pharmacology, 1992-12, Vol.107 (4), p.1013-1019

1992

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Guanine nucleotide sensitivity of [ 3H]iloprost binding to prostacyclin receptors

European journal of pharmacology, 1991-06, Vol.207 (2), p.111-117

1991

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Phorbol ester enhances activation of adenylate cyclase in Bovine aortic endothelial cells

Life sciences (1973), 1994, Vol.54 (2), p.87-94

1994

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Prostacyclin analogues reduce ADP‐ribosylation of the α‐subunit of the regulatory Gs‐protein and diminish adenosine (A2) responsiveness of platelets

British journal of pharmacology, 1987-03, Vol.90 (3), p.501-510

1987

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Octimibate, a potent non‐prostanoid inhibitor of platelet aggregation, acts via the prostacyclin receptor

British journal of pharmacology, 1991-01, Vol.102 (1), p.251-259

1991

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A physiology classic revisited after 60 years

BMJ. British medical journal (International ed.), 1996-04, Vol.312 (7037), p.1029

International edition, 1996

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IgE and IgG are synergistic in antigen-mediated release of thromboxane from human lung macrophages

Cellular immunology, 1991-04, Vol.134 (1), p.138-146

1991

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Identification of the prostacyclin receptor by radiation inactivation

The Journal of biological chemistry, 1984-10, Vol.259 (20), p.12431-12436

1984

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Bradykinin‐induced release of PGI2 from aortic endothelial cell lines: responses mediated selectively by Ca2+ ions or a staurosporine‐sensitive kinase

British journal of pharmacology, 1993-09, Vol.110 (1), p.411-415

1993

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NaF and guanine nucleotides modulate adenylate cyclase activity in NG108‐15 cells by interacting with both Gs and Gi

British journal of pharmacology, 1990-06, Vol.100 (2), p.223-230

1990

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Thromboxane release by lymphokine-differentiated U937 human monocytic cells: response to platelet-activating factor (PAF) and chemotactic peptide (FMLP) but not to low affinity IGE-receptor (Fc epsilon RII/CD23) occupation

Journal of leukocyte biology, 1990-09, Vol.48 (3), p.266-273

1990

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Increased pulmonary α -adrenergic and reduced β -adrenergic receptors in experimental asthma

Nature (London), 1980-06, Vol.285 (5766), p.569-571

1980

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Adenylate Cyclase and Acetylcholine Release Regulated by Separate Serotonin Receptors of Somatic Cell Hybrids

Proceedings of the National Academy of Sciences - PNAS, 1979-03, Vol.76 (3), p.1135-1139

1979

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Inactivation of platelet‐derived growth factor‐BB following modification by ADP‐ribosyltransferase

British journal of pharmacology, 2001-08, Vol.133 (8), p.1219-1226

2001

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Activation of bovine endothelial thromboxane receptors triggers release of prostacyclin but not EDRF

Cardiovascular research, 1992-05, Vol.26 (5), p.513-517

1992

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The molecular mechanisms of drug action

Neuropathic pain in Anderson-Fabry disease: pathology and therapeutic options

The N-terminal thrombin receptor fragment SFLLRN, but not catalytically inactive thrombin-derived agonists, activate U937 human monocytic cells : evidence for receptor hydrolysis in thrombin-dependent signalling

Pyocyanin and 1-hydroxyphenazine produced by Pseudomonas aeruginosa inhibit the beating of human respiratory cilia in vitro

Inhibition of chemotaxis in A7r5 rat smooth muscle cells by a novel panel of inhibitors

Arginine-specific ADP-ribosyltransferases in leukocytes

Thrombin promotes actin polymerization in U937 human monocyte-macrophage cells : analysis of the signalling mechanisms mediating actin polymerization

Impairment of function in aging neutrophils is associated with apoptosis

Reduction by inhibitors of mono(ADP‐ribosyl)transferase of chemotaxis in human neutrophil leucocytes by inhibition of the assembly of filamentous actin

Human calcitonin gene‐related peptide activates adenylate cyclase and releases prostacyclin from human umbilical vein endothelial cells

Differential sensitivities of the prostacyclin and nitric oxide biosynthetic pathways to cytosolic calcium in bovine aortic endothelial cells

Guanine nucleotide sensitivity of [ 3H]iloprost binding to prostacyclin receptors

Phorbol ester enhances activation of adenylate cyclase in Bovine aortic endothelial cells

Prostacyclin analogues reduce ADP‐ribosylation of the α‐subunit of the regulatory Gs‐protein and diminish adenosine (A2) responsiveness of platelets

Octimibate, a potent non‐prostanoid inhibitor of platelet aggregation, acts via the prostacyclin receptor

A physiology classic revisited after 60 years

IgE and IgG are synergistic in antigen-mediated release of thromboxane from human lung macrophages

Identification of the prostacyclin receptor by radiation inactivation

Bradykinin‐induced release of PGI2 from aortic endothelial cell lines: responses mediated selectively by Ca2+ ions or a staurosporine‐sensitive kinase

NaF and guanine nucleotides modulate adenylate cyclase activity in NG108‐15 cells by interacting with both Gs and Gi

Thromboxane release by lymphokine-differentiated U937 human monocytic cells: response to platelet-activating factor (PAF) and chemotactic peptide (FMLP) but not to low affinity IGE-receptor (Fc epsilon RII/CD23) occupation

Increased pulmonary α -adrenergic and reduced β -adrenergic receptors in experimental asthma

Adenylate Cyclase and Acetylcholine Release Regulated by Separate Serotonin Receptors of Somatic Cell Hybrids

Inactivation of platelet‐derived growth factor‐BB following modification by ADP‐ribosyltransferase

Activation of bovine endothelial thromboxane receptors triggers release of prostacyclin but not EDRF

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