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Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions

Pharmacological reviews, 2013-04, Vol.65 (2), p.670

2013

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Recent Patents in Allergy/Immunology: Use of arginase inhibitors in the treatment of asthma and allergic rhinitis

Allergy (Copenhagen), 2019-06, Vol.74 (6), p.1206-1208

2019

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Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives

British journal of pharmacology, 2009-10, Vol.158 (3), p.652-664

2009

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Arginine Therapy for Lung Diseases

Frontiers in pharmacology, 2021-03, Vol.12, p.627503

2021

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Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection in asthma models

The Journal of clinical investigation, 2023-09, Vol.133 (18), p.1-13

2023

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Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices

PloS one, 2013-06, Vol.8 (6), p.e65580

2013

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Combination therapy of tiotropium and ciclesonide attenuates airway inflammation and remodeling in a guinea pig model of chronic asthma

Respiratory research, 2016-02, Vol.17 (14), p.13-13, Article 13

2016

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Anti-inflammatory role of the cAMP effectors Epac and PKA: implications in chronic obstructive pulmonary disease

PloS one, 2012-02, Vol.7 (2), p.e31574-e31574

2012

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Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke

The FASEB journal, 2014-11, Vol.28 (11), p.4617-4628

2014

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A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle

American journal of physiology. Lung cellular and molecular physiology, 2015-04, Vol.308 (8), p.L766-L775

2015

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Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung

Pharmaceuticals, 2012-11, Vol.5 (12), p.1291-1331

2012

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Muscarinic receptors on airway mesenchymal cells: Novel findings for an ancient target

Pulmonary pharmacology & therapeutics, 2013-02, Vol.26 (1), p.145-155

2013

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Arginase Inhibition Protects against Allergen-induced Airway Obstruction, Hyperresponsiveness, and Inflammation

American journal of respiratory and critical care medicine, 2008-09, Vol.178 (6), p.565-573

2008

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Epac as a novel effector of airway smooth muscle relaxation

Journal of cellular and molecular medicine, 2011-07, Vol.15 (7), p.1551-1563

2011

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Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma

Respiratory research, 2006-01, Vol.7 (1), p.6-6, Article 6

2006

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β3-Adrenoceptor-mediated relaxation of rat and human urinary bladder: roles of BKCa channels and Rho kinase

Naunyn-Schmiedeberg's archives of pharmacology, 2015-07, Vol.388 (7), p.749-759

2015

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Effects of (a Combination of) the Beta2-Adrenoceptor Agonist Indacaterol and the Muscarinic Receptor Antagonist Glycopyrrolate on Intrapulmonary Airway Constriction

Cells (Basel, Switzerland), 2021-05, Vol.10 (5), p.1237

2021

Volltextzugriff (PDF)

A-Kinase Anchoring Proteins Diminish TGF-β1/Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition

Cells (Basel, Switzerland), 2020-02, Vol.9 (2), p.356

2020

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cAMP inhibits modulation of airway smooth muscle phenotype via the exchange protein activated by cAMP (Epac) and protein kinase A

British journal of pharmacology, 2011-01, Vol.162 (1), p.193-209

2011

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Models to study airway smooth muscle contraction in vivo , ex vivo and in vitro : Implications in understanding asthma

Pulmonary pharmacology & therapeutics, 2013-02, Vol.26 (1), p.24-36

2013

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Airway contractility and remodeling: Links to asthma symptoms

Pulmonary pharmacology & therapeutics, 2013-02, Vol.26 (1), p.3-12

2013

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Disruption of AKAP-PKA Interaction Induces Hypercontractility With Concomitant Increase in Proliferation Markers in Human Airway Smooth Muscle

Frontiers in cell and developmental biology, 2020-04, Vol.8, p.165-165

2020

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Increased arginase activity underlies allergen‐induced deficiency of cNOS‐derived nitric oxide and airway hyperresponsiveness

British journal of pharmacology, 2002-06, Vol.136 (3), p.391-398

2002

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Arginase and pulmonary diseases

Naunyn-Schmiedeberg's archives of pharmacology, 2008-08, Vol.378 (2), p.171-184

2008

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Endothelial follistatin-like-1 regulates the postnatal development of the pulmonary vasculature by modulating BMP/Smad signaling

Pulmonary circulation, 2017-03, Vol.7 (1), p.219-231

2017

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Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions

Recent Patents in Allergy/Immunology: Use of arginase inhibitors in the treatment of asthma and allergic rhinitis

Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives

Arginine Therapy for Lung Diseases

Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection in asthma models

Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices

Combination therapy of tiotropium and ciclesonide attenuates airway inflammation and remodeling in a guinea pig model of chronic asthma

Anti-inflammatory role of the cAMP effectors Epac and PKA: implications in chronic obstructive pulmonary disease

Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke

A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle

Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung

Muscarinic receptors on airway mesenchymal cells: Novel findings for an ancient target

Arginase Inhibition Protects against Allergen-induced Airway Obstruction, Hyperresponsiveness, and Inflammation

Epac as a novel effector of airway smooth muscle relaxation

Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma

β3-Adrenoceptor-mediated relaxation of rat and human urinary bladder: roles of BKCa channels and Rho kinase

Effects of (a Combination of) the Beta2-Adrenoceptor Agonist Indacaterol and the Muscarinic Receptor Antagonist Glycopyrrolate on Intrapulmonary Airway Constriction

A-Kinase Anchoring Proteins Diminish TGF-β1/Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition

cAMP inhibits modulation of airway smooth muscle phenotype via the exchange protein activated by cAMP (Epac) and protein kinase A

Models to study airway smooth muscle contraction in vivo , ex vivo and in vitro : Implications in understanding asthma

Airway contractility and remodeling: Links to asthma symptoms

Disruption of AKAP-PKA Interaction Induces Hypercontractility With Concomitant Increase in Proliferation Markers in Human Airway Smooth Muscle

Increased arginase activity underlies allergen‐induced deficiency of cNOS‐derived nitric oxide and airway hyperresponsiveness

Arginase and pulmonary diseases

Endothelial follistatin-like-1 regulates the postnatal development of the pulmonary vasculature by modulating BMP/Smad signaling

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