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The Role of Ageing and Parenchymal Senescence on Macrophage Function and Fibrosis

Frontiers in immunology, 2021-06, Vol.12, p.700790-700790

2021

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Macrophages and Renal Fibrosis

Seminars in nephrology, 2010-05, Vol.30 (3), p.302-317

2010

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Conditional ablation of macrophages disrupts ovarian vasculature

Reproduction (Cambridge, England), 2011-06, Vol.141 (6), p.821-831

2011

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Depletion of cells of monocyte lineage prevents loss of renal microvasculature in murine kidney transplantation

Transplantation, 2008-11, Vol.86 (9), p.1267-1274

2008

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Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair

Science translational medicine, 2021-05, Vol.13 (594)

2021

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Bone marrow transplantation modulates tissue macrophage phenotype and enhances cardiac recovery after subsequent acute myocardial infarction

Journal of molecular and cellular cardiology, 2016-01, Vol.90, p.120-128

2016

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Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

JCI insight, 2022-11, Vol.7 (22)

2022

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Complementary Roles for Single-Nucleus and Single-Cell RNA Sequencing in Kidney Disease Research

Journal of the American Society of Nephrology, 2019-04, Vol.30 (4), p.712-713

2019

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Targeting Senescent Cells as Therapy for CKD

Kidney360, 2024-01, Vol.5 (1), p.142-151

2024

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Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis

Science translational medicine, 2023-05, Vol.15 (698), p.eabn0736

2023

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Alternatively Activated Macrophages Elicited by Helminth Infection Can Be Reprogrammed to Enable Microbial Killing

The Journal of immunology (1950), 2009-03, Vol.182 (5), p.3084-3094

2009

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Therapeutic Approaches to Aging

JAMA : the journal of the American Medical Association, 2019-03, Vol.321 (9), p.901

2019

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Plasmodium chabaudi limits early Nippostrongylus brasiliensis-induced pulmonary immune activation and Th2 polarization in co-infected mice

BMC immunology, 2009-12, Vol.10 (1), p.60-60, Article 60

2009

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11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI

Journal of endocrinology, 2017-06, Vol.233 (3), p.315-327

2017

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11 beta -HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI

Journal of endocrinology, 2017-06, Vol.233 (3), p.315-327

2017

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Cardiomyocyte and Vascular Smooth Muscle-Independent 11β-Hydroxysteroid Dehydrogenase 1 Amplifies Infarct Expansion, Hypertrophy, and the Development of Heart Failure After Myocardial Infarction in Male Mice

Endocrinology (Philadelphia), 2016-01, Vol.157 (1), p.346-357

2016

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The adult murine heart has a sparse, phagocytically active macrophage population that expands through monocyte recruitment and adopts an ‘M2’ phenotype in response to Th2 immunologic challenge

Immunobiology (1979), 2015-07, Vol.220 (7), p.924-933

2015

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Granulocyte macrophage-colony stimulating factor: A key modulator of renal mononuclear phagocyte plasticity

Immunobiology (1979), 2019-01, Vol.224 (1), p.60-74

2019

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Contrasting effects of Elg1-RFC and Ctf18-RFC inactivation in the absence of fully functional RFC in fission yeast

Nucleic acids research, 2005-01, Vol.33 (13), p.4078-4089

2005

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Alternative activation of macrophages by filarial nematodes is MyD88-independent

Immunobiology (1979), 2013-04, Vol.218 (4), p.570-578

2013

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Induced Senescent Cells Recruit Leukocytes and Permit Their Own Clearance from Healthy Young Kidneys: TH-OR15

Journal of the American Society of Nephrology, 2023-11, Vol.34 (11S), p.4-4

2023

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10 Macrophage-derived wnts are required for scar-free regeneration of the neonatal mouse myocardium

Heart (British Cardiac Society), 2017-04, Vol.103 (Suppl 2), p.A4

2017

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A Multi-Omics Approach to Renal Epithelial Senescence Urinary Biomarker Discovery: TH-PO1074

Journal of the American Society of Nephrology, 2023-11, Vol.34 (11S), p.393-393

2023

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Single-Cell Analysis of Senescent Epithelia Reveals Targetable Mechanisms Promoting Fibrosis: PO0643

Journal of the American Society of Nephrology, 2021-10, Vol.32 (10S), p.236-236

2021

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216 Immediate Pharmacological Inhibition of Local Glucocorticoid Generation increases Angiogenesis and Improves Cardiac Funcion after Myocardial Infarction

Heart (British Cardiac Society), 2014-06, Vol.100 (Suppl 3), p.A118-A118

2014

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The Role of Ageing and Parenchymal Senescence on Macrophage Function and Fibrosis

Macrophages and Renal Fibrosis

Conditional ablation of macrophages disrupts ovarian vasculature

Depletion of cells of monocyte lineage prevents loss of renal microvasculature in murine kidney transplantation

Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair

Bone marrow transplantation modulates tissue macrophage phenotype and enhances cardiac recovery after subsequent acute myocardial infarction

Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

Complementary Roles for Single-Nucleus and Single-Cell RNA Sequencing in Kidney Disease Research

Targeting Senescent Cells as Therapy for CKD

Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis

Alternatively Activated Macrophages Elicited by Helminth Infection Can Be Reprogrammed to Enable Microbial Killing

Therapeutic Approaches to Aging

Plasmodium chabaudi limits early Nippostrongylus brasiliensis-induced pulmonary immune activation and Th2 polarization in co-infected mice

11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI

11 beta -HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI

Cardiomyocyte and Vascular Smooth Muscle-Independent 11β-Hydroxysteroid Dehydrogenase 1 Amplifies Infarct Expansion, Hypertrophy, and the Development of Heart Failure After Myocardial Infarction in Male Mice

The adult murine heart has a sparse, phagocytically active macrophage population that expands through monocyte recruitment and adopts an ‘M2’ phenotype in response to Th2 immunologic challenge

Granulocyte macrophage-colony stimulating factor: A key modulator of renal mononuclear phagocyte plasticity

Contrasting effects of Elg1-RFC and Ctf18-RFC inactivation in the absence of fully functional RFC in fission yeast

Alternative activation of macrophages by filarial nematodes is MyD88-independent

Induced Senescent Cells Recruit Leukocytes and Permit Their Own Clearance from Healthy Young Kidneys: TH-OR15

10 Macrophage-derived wnts are required for scar-free regeneration of the neonatal mouse myocardium

A Multi-Omics Approach to Renal Epithelial Senescence Urinary Biomarker Discovery: TH-PO1074

Single-Cell Analysis of Senescent Epithelia Reveals Targetable Mechanisms Promoting Fibrosis: PO0643

216 Immediate Pharmacological Inhibition of Local Glucocorticoid Generation increases Angiogenesis and Improves Cardiac Funcion after Myocardial Infarction

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