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Cartilage repair and the sprifermin story: mechanisms, preclinical and clinical study results, and lessons learned

Osteoarthritis and cartilage, 2016-04, Vol.24, p.S4-S4

Muurahainen, N

2016

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Development of a Disease-Modifying OA Drug (DMOAD) in Knee Osteoarthritis: The Example of Sprifermin

Drug research, 2015-11, Vol.65 Suppl 1, p.S13

2015

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Two-year change in cartilage thickness on quantitative magnetic resonance imaging (qMRI) and joint space width (JSW) on X-ray demonstrate similar predictive performance for knee replacement in OA subjects eligible for clinical trials

Osteoarthritis and cartilage, 2016-04, Vol.24, p.S260-S261

2016

Volltextzugriff (PDF)

AB0852 Sprifermin Alters Cartilage Morphology and Subchondral Bone Marrow Lesions in Knee Osteoarthritis

Annals of the rheumatic diseases, 2015-06, Vol.74 (Suppl 2), p.1185-1186

2015

Volltextzugriff (PDF)

A first-in-human, double-blind, randomised, placebo-controlled, dose ascending study of intra-articular rhFGF18 (sprifermin) in patients with advanced knee osteoarthritis

Clinical and experimental rheumatology, 2016-05, Vol.34 (3), p.445

2016

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Recombinant human growth hormone to treat HIV-associated adipose redistribution syndrome: 12 week induction and 24-week maintenance therapy

Journal of acquired immune deficiency syndromes (1999), 2007-07, Vol.45 (3), p.286

2007

Volltextzugriff (PDF)

Clinical trials update in human immunodeficiency virus wasting

Seminars in oncology, 1998-04, Vol.25 (2), p.104-111

1998

Volltextzugriff (PDF)

Intravenous infusion of bombesin reduces food intake in humans

American journal of physiology. Regulatory, integrative and comparative physiology, 1993-02, Vol.264 (2), p.350-R354

1993

Volltextzugriff (PDF)

Effects of growth hormone on abnormal visceral adipose tissue accumulation and dyslipidemia in HIV-infected patients

Journal of acquired immune deficiency syndromes (1999), 2004-03, Vol.35 (3), p.239

2004

Volltextzugriff (PDF)

Effect of a soup preload on reduction of food intake by cholecystokinin in humans

American journal of physiology. Regulatory, integrative and comparative physiology, 1991-04, Vol.260 (4), p.672-R680

1991

Volltextzugriff (PDF)

Protein Intake Is Positively Associated with Body Cell Mass in Weight-Stable HIV-Infected Men

The Journal of nutrition, 2003-04, Vol.133 (4), p.1143-1146

2003

Volltextzugriff (PDF)

Relationships among nutritional status, disease progression, and survival in HIV infection

Journal of acquired immune deficiency syndromes (1988), 1993-10, Vol.6 (10), p.1130

1993

Volltextzugriff (PDF)

A randomized, placebo-controlled trial of combined insulin-like growth factor I and low dose growth hormone therapy for wasting associated with human immunodeficiency virus infection

The journal of clinical endocrinology and metabolism, 1996-08, Vol.81 (8), p.2968-2975

1996

Volltextzugriff (PDF)

Different factors are associated with lipohypertrophy and lipoatrophy in HIV patients with fat maldistribution

AIDS (London), 2000-10, Vol.14, p.S59-S60

2000

Volltextzugriff (PDF)

Gains in lean body mass (LBM) and not body fat are associated with improved survival in patients with AIDS wasting (AW)

AIDS (London), 2000-10, Vol.14, p.S60-S60

2000

Volltextzugriff (PDF)

Randomized, controlled trial of caloric supplements in HIV infection. Terry Beirn Community Programs for Clinical Research on AIDS

Journal of acquired immune deficiency syndromes (1999), 1999-11, Vol.22 (3), p.253

1999

Volltextzugriff (PDF)

Trends in weight and body cell mass (BCM) changes in HIV-infected men

Nutrition (Burbank, Los Angeles County, Calif.), 1997-03, Vol.13 (3), p.286-286

1997

Volltextzugriff (PDF)

Body composition and frequency of muscle building activities in HIV-infected men

Nutrition (Burbank, Los Angeles County, Calif.), 1997-03, Vol.13 (3), p.286-286

1997

Volltextzugriff (PDF)

Effects of cholecystokinin-octapeptide (CCK-8) on food intake and gastric emptying in man

Physiology & behavior, 1988, Vol.44 (4), p.645-649

1988

Volltextzugriff (PDF)

A randomized, placebo-controlled trial of combined insulin-like growth factor I and low dose growth hormone therapy for wasting associated with human immunodeficiency virus infection

The journal of clinical endocrinology and metabolism, 1996-08, Vol.81 (8), p.2968-2975

1996

Volltextzugriff (PDF)

Intravenous infusion of bombesin reduces food intake in humans

American journal of physiology. Regulatory, integrative and comparative physiology, 1993, Vol.33 (2), p.R350-R354

1993

Volltextzugriff (PDF)

Effect of a soup preload on reduction of food intake by cholecystokinin in humans

American journal of physiology. Regulatory, integrative and comparative physiology, 1991, Vol.29 (4), p.R672-R680

1991

Volltextzugriff (PDF)

Weight loss as a predictor of survival and disease progression in HIV infection. Terry Beirn Community Programs for Clinical Research on AIDS

Journal of acquired immune deficiency syndromes and human retrovirology, 1998-05, Vol.18 (1), p.80

1998

Volltextzugriff (PDF)

Relationship among nutritional status, disease progression, and survival in HIV infection

Journal of acquired immune deficiency syndromes (1988), 1993, Vol.6 (10), p.1130-1138

1993

Volltextzugriff (PDF)

Multicystic nephroblastoma: ultrasound diagnosis (with a pathologic-anatomic commentary)

Pediatric radiology, 1982, Vol.12 (1), p.43-47

1982

Volltextzugriff (PDF)

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Cartilage repair and the sprifermin story: mechanisms, preclinical and clinical study results, and lessons learned

Development of a Disease-Modifying OA Drug (DMOAD) in Knee Osteoarthritis: The Example of Sprifermin

Two-year change in cartilage thickness on quantitative magnetic resonance imaging (qMRI) and joint space width (JSW) on X-ray demonstrate similar predictive performance for knee replacement in OA subjects eligible for clinical trials

AB0852 Sprifermin Alters Cartilage Morphology and Subchondral Bone Marrow Lesions in Knee Osteoarthritis

A first-in-human, double-blind, randomised, placebo-controlled, dose ascending study of intra-articular rhFGF18 (sprifermin) in patients with advanced knee osteoarthritis

Recombinant human growth hormone to treat HIV-associated adipose redistribution syndrome: 12 week induction and 24-week maintenance therapy

Clinical trials update in human immunodeficiency virus wasting

Intravenous infusion of bombesin reduces food intake in humans

Effects of growth hormone on abnormal visceral adipose tissue accumulation and dyslipidemia in HIV-infected patients

Effect of a soup preload on reduction of food intake by cholecystokinin in humans

Protein Intake Is Positively Associated with Body Cell Mass in Weight-Stable HIV-Infected Men

Relationships among nutritional status, disease progression, and survival in HIV infection

A randomized, placebo-controlled trial of combined insulin-like growth factor I and low dose growth hormone therapy for wasting associated with human immunodeficiency virus infection

Different factors are associated with lipohypertrophy and lipoatrophy in HIV patients with fat maldistribution

Gains in lean body mass (LBM) and not body fat are associated with improved survival in patients with AIDS wasting (AW)

Randomized, controlled trial of caloric supplements in HIV infection. Terry Beirn Community Programs for Clinical Research on AIDS

Trends in weight and body cell mass (BCM) changes in HIV-infected men

Body composition and frequency of muscle building activities in HIV-infected men

Effects of cholecystokinin-octapeptide (CCK-8) on food intake and gastric emptying in man

A randomized, placebo-controlled trial of combined insulin-like growth factor I and low dose growth hormone therapy for wasting associated with human immunodeficiency virus infection

Intravenous infusion of bombesin reduces food intake in humans

Effect of a soup preload on reduction of food intake by cholecystokinin in humans

Weight loss as a predictor of survival and disease progression in HIV infection. Terry Beirn Community Programs for Clinical Research on AIDS

Relationship among nutritional status, disease progression, and survival in HIV infection

Multicystic nephroblastoma: ultrasound diagnosis (with a pathologic-anatomic commentary)

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