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Mapping microglia states in the human brain through the integration of high-dimensional techniques

Nature neuroscience, 2019-12, Vol.22 (12), p.2098-2110

2019

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Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer’s disease and other tauopathies

European journal of nuclear medicine and molecular imaging, 2019-09, Vol.46 (10), p.2178-2189

2019

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Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy

PloS one, 2013-08, Vol.8 (8), p.e72301-e72301

2013

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Aβ42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete Aβ42 Species

The Journal of biological chemistry, 2011-03, Vol.286 (10), p.8585-8596

2011

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Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement

Cell reports (Cambridge), 2016-08, Vol.16 (6), p.1690-1700

2016

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Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression

Scientific reports, 2018-11, Vol.8 (1), p.16725-15, Article 16725

2018

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An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome

PloS one, 2016-03, Vol.11 (3), p.e0152471-e0152471

2016

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Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice

Proceedings of the National Academy of Sciences - PNAS, 2007-06, Vol.104 (23), p.9810-9815

2007

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Human genome–guided identification of memory-modulating drugs

Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (46), p.E4369-E4374

2013

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Engineering amyloid-like assemblies from unstructured peptides via site-specific lipid conjugation

PloS one, 2014-09, Vol.9 (9), p.e105641

2014

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Development of a small D-enantiomeric Alzheimer's amyloid-β binding peptide ligand for future in vivo imaging applications

PloS one, 2012-07, Vol.7 (7), p.e41457-e41457

2012

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PRECLINICAL CHARACTERIZATION OF PI-2620, A NOVEL TAU PET TRACER FOR DETECTION OF TAU IN AD AND OTHER TAUOPATHIES

Alzheimer's & dementia, 2017-07, Vol.13 (7), p.P141-P142

2017

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Cognitive enhancers (nootropics). Part 1: drugs interacting with receptors

Journal of Alzheimer's disease, 2012-01, Vol.32 (4), p.793-887

2012

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Cognitive enhancers (Nootropics). Part 1: drugs interacting with receptors. Update 2014

Journal of Alzheimer's disease, 2014-01, Vol.41 (4), p.961-1019

2014

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A beta 42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete A beta 42 Species

The Journal of biological chemistry, 2011-03, Vol.286 (10), p.8585-8596

2011

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Binding Affinity Measurement of Antibodies from Crude Hybridoma Samples by SPR

Bio-protocol, 2014-11, Vol.4 (21)

2014

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An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ

The Journal of neuroscience, 2012-07, Vol.32 (28), p.9677-9689

2012

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Cognitive enhancers (nootropics). Part 3: drugs interacting with targets other than receptors or enzymes. disease-modifying drugs

Journal of Alzheimer's disease, 2013-01, Vol.34 (1), p.1-114

2013

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Cognitive enhancers (nootropics). Part 2: drugs interacting with enzymes. Update 2014

Journal of Alzheimer's disease, 2014-01, Vol.42 (1), p.1-68

2014

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Cognitive enhancers (nootropics). Part 2: drugs interacting with enzymes

Journal of Alzheimer's disease, 2013-01, Vol.33 (3), p.547-658

2013

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Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin

Scientific reports, 2016-12, Vol.6 (1), p.39374, Article 39374

2016

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A Short Synthesis of the 2‑Bromo‑N,9-dimethyl-6,7,8,9-tetrahydro‑5H‑pyrido[2,3‑b]indol-6-amine Building Block

Organic process research & development, 2019-11, Vol.23 (11), p.2521-2526

2019

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Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease

Science translational medicine, 2021-05, Vol.13 (593)

2021

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A Short Synthesis of the 2-Bromo- N ,9-dimethyl-6,7,8,9-tetrahydro-5 H -pyrido[2,3- b ]indol-6-amine Building Block

Organic process research & development, 2019-11, Vol.23 (11), p.2521-2526

2019

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BACE-1 is expressed in the blood–brain barrier endothelium and is upregulated in a murine model of Alzheimer’s disease

Journal of cerebral blood flow and metabolism, 2016-07, Vol.36 (7), p.1281-1294

2016

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Mapping microglia states in the human brain through the integration of high-dimensional techniques

Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer’s disease and other tauopathies

Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy

Aβ42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete Aβ42 Species

Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement

Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression

An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome

Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice

Human genome–guided identification of memory-modulating drugs

Engineering amyloid-like assemblies from unstructured peptides via site-specific lipid conjugation

Development of a small D-enantiomeric Alzheimer's amyloid-β binding peptide ligand for future in vivo imaging applications

PRECLINICAL CHARACTERIZATION OF PI-2620, A NOVEL TAU PET TRACER FOR DETECTION OF TAU IN AD AND OTHER TAUOPATHIES

Cognitive enhancers (nootropics). Part 1: drugs interacting with receptors

Cognitive enhancers (Nootropics). Part 1: drugs interacting with receptors. Update 2014

A beta 42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete A beta 42 Species

Binding Affinity Measurement of Antibodies from Crude Hybridoma Samples by SPR

An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ

Cognitive enhancers (nootropics). Part 3: drugs interacting with targets other than receptors or enzymes. disease-modifying drugs

Cognitive enhancers (nootropics). Part 2: drugs interacting with enzymes. Update 2014

Cognitive enhancers (nootropics). Part 2: drugs interacting with enzymes

Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin

A Short Synthesis of the 2‑Bromo‑N,9-dimethyl-6,7,8,9-tetrahydro‑5H‑pyrido[2,3‑b]indol-6-amine Building Block

Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease

A Short Synthesis of the 2-Bromo- N ,9-dimethyl-6,7,8,9-tetrahydro-5 H -pyrido[2,3- b ]indol-6-amine Building Block

BACE-1 is expressed in the blood–brain barrier endothelium and is upregulated in a murine model of Alzheimer’s disease

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