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Alzheimer Mechanisms and Therapeutic Strategies

Cell, 2012-03, Vol.148 (6), p.1204-1222

2012

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Network abnormalities and interneuron dysfunction in Alzheimer disease

Nature reviews. Neuroscience, 2016-12, Vol.17 (12), p.777-792

2016

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Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies

Science (American Association for the Advancement of Science), 2021-02, Vol.371 (6532)

2021

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100 Years and Counting: Prospects for Defeating Alzheimer's Disease

Science (American Association for the Advancement of Science), 2006-11, Vol.314 (5800), p.781-784

2006

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Paths of Convergence: Sirtuins in Aging and Neurodegeneration

Neuron (Cambridge, Mass.), 2008-04, Vol.58 (1), p.10-14

2008

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Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

Nature neuroscience, 2015-08, Vol.18 (8), p.1183-1189

2015

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A network dysfunction perspective on neurodegenerative diseases

Nature, 2006-10, Vol.443 (7113), p.768-773

2006

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Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (42), p.E2895-E2903

2012

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Incidence and impact of subclinical epileptiform activity in Alzheimer's disease

Annals of neurology, 2016-12, Vol.80 (6), p.858-870

2016

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Neuroscience Alzheimer's disease

Nature (London), 2009-10, Vol.461 (7266), p.895-897

Mucke, Lennart

2009

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Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

Cell, 2012-04, Vol.149 (3), p.708-721

2012

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Tau reduction affects excitatory and inhibitory neurons differently, reduces excitation/inhibition ratios, and counteracts network hypersynchrony

Cell reports (Cambridge), 2021-10, Vol.37 (3), p.109855-109855, Article 109855

2021

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DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice

Nature communications, 2015-11, Vol.6 (1), p.8897-8897, Article 8897

2015

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Seizures and epileptiform activity in the early stages of Alzheimer disease

JAMA neurology, 2013-09, Vol.70 (9), p.1158

2013

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Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease

Acta neuropathologica communications, 2019-05, Vol.7 (1), p.77-77, Article 77

2019

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Age-appropriate cognition and subtle dopamine-independent motor deficits in aged Tau knockout mice

Neurobiology of aging, 2013-06, Vol.34 (6), p.1523-1529

2013

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A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease

Science translational medicine, 2020-08, Vol.12 (558)

2020

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Tau reduction prevents disease in a mouse model of Dravet syndrome

Annals of neurology, 2014-09, Vol.76 (3), p.443-456

2014

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Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice

EMBO reports, 2016-04, Vol.17 (4), p.530-551

2016

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Istradefylline reduces memory deficits in aging mice with amyloid pathology

Neurobiology of disease, 2018-02, Vol.110, p.29-36

2018

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Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease

Neuron (Cambridge, Mass.), 2007-09, Vol.55 (5), p.697-711

2007

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Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease

Cell stem cell, 2009-12, Vol.5 (6), p.624-633

2009

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Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture

Molecular neurodegeneration, 2017-05, Vol.12 (1), p.41-19, Article 41

2017

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Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models

Neurobiology of disease, 2023-10, Vol.186, p.106263-106263, Article 106263

2023

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Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease

PloS one, 2011-12, Vol.6 (12), p.e29257-e29257

2011

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Alzheimer Mechanisms and Therapeutic Strategies

Network abnormalities and interneuron dysfunction in Alzheimer disease

Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies

100 Years and Counting: Prospects for Defeating Alzheimer's Disease

Paths of Convergence: Sirtuins in Aging and Neurodegeneration

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

A network dysfunction perspective on neurodegenerative diseases

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model

Incidence and impact of subclinical epileptiform activity in Alzheimer's disease

Neuroscience Alzheimer's disease

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

Tau reduction affects excitatory and inhibitory neurons differently, reduces excitation/inhibition ratios, and counteracts network hypersynchrony

DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice

Seizures and epileptiform activity in the early stages of Alzheimer disease

Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease

Age-appropriate cognition and subtle dopamine-independent motor deficits in aged Tau knockout mice

A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease

Tau reduction prevents disease in a mouse model of Dravet syndrome

Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice

Istradefylline reduces memory deficits in aging mice with amyloid pathology

Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease

Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease

Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture

Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models

Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease

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