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Molecular basis for clinical diversity between autoantibody subsets in diffuse cutaneous systemic sclerosis

Annals of the rheumatic diseases, 2021-12, Vol.80 (12), p.1584

2021

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Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

Nature immunology, 2003-08, Vol.4 (8), p.794-800

2003

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Four N-linked Glycosylation Sites in Human Toll-like Receptor 2 Cooperate to Direct Efficient Biosynthesis and Secretion

The Journal of biological chemistry, 2004-08, Vol.279 (33), p.34589-34594

2004

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3D model of harlequin ichthyosis reveals inflammatory therapeutic targets

The Journal of clinical investigation, 2020-09, Vol.130 (9), p.4798-4810

2020

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BET bromodomain inhibitors show anti-papillomavirus activity in vitro and block CRPV wart growth in vivo

Antiviral research, 2018-06, Vol.154, p.158-165

2018

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Integrated analysis of dermal blister fluid proteomics and genome-wide skin gene expression in systemic sclerosis: an observational study

The Lancet. Rheumatology, 2022-07, Vol.4 (7), p.e507-e516

2022

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Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses

Journal of medicinal chemistry, 2016-02, Vol.59 (3), p.1003-1020

2016

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4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy

Bioorganic & medicinal chemistry letters, 2012-08, Vol.22 (16), p.5222-5226

2012

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Discovery of 6-Aryl-7-alkoxyisoquinoline Inhibitors of IκB Kinase-β (IKK-β)

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.3098-3102

2009

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The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-α and IKK-β kinases

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3972-3977

2007

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3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IKK-β

Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (8), p.2255-2258

2011

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4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2504-2508

2009

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Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate

ACS medicinal chemistry letters, 2011-06, Vol.2 (6), p.444-449

2011

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Development of an insect-cell-based assay for detection of kinase inhibition using NF-κB-inducing kinase as a paradigm

Biochemical journal, 2009-04, Vol.419 (1), p.65-73

2009

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GRID: A Novel Grb-2-Related Adapter Protein That Interacts with the Activated T Cell Costimulatory Receptor CD28

The Journal of immunology (1950), 2000-06, Vol.164 (11), p.5805-5814

2000

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P154 High-density proteomic analysis of skin blister fluid and plasma in systemic sclerosis identifies local and systemic differences for key proteins

Rheumatology (Oxford, England), 2021-04, Vol.60 (Supplement_1)

2021

Volltextzugriff (PDF)

3D model of harlequin ichthyosis reveals inflammatory therapeutic targets

The Journal of clinical investigation, 2020-09, Vol.130 (9), p.4798-4810

2020

Volltextzugriff (PDF)

P229 Integrated analysis of dermal blister fluid proteomics and skin biopsy transcriptomics gives new insight into pathogenesis of systemic sclerosis

Rheumatology (Oxford, England), 2022-04, Vol.61 (Supplement_1)

2022

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O18 Integrated molecular analysis of systemic sclerosis skin and blood shows significant differences between major autoantibody subgroups

Rheumatology (Oxford, England), 2021-04, Vol.60 (Supplement_1)

2021

Volltextzugriff (PDF)

Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P 3 )-Sparing S1P 1 Agonists Active at Low Oral Doses

Journal of medicinal chemistry, 2016-02, Vol.59 (3), p.1003-1020

2016

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Targeting IKKβ for the treatment of rheumatoid arthritis

Drug news & perspectives, 2010-10, Vol.23 (8), p.483-490

2010

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Discovery of a Brain-Penetrant S1P3-Sparing Direct Agonist of the S1P1 and S1P5 Receptors Efficacious at Low Oral Dose

Journal of medicinal chemistry, 2011-10, Vol.54 (19), p.6724-6733

2011

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3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IIK-β

Bioorganic & medicinal chemistry letters, 2011, Vol.21 (8), p.2255-2258

2011

Volltextzugriff (PDF)

The p85 subunit of phosphoinositide 3-kinase is associated with beta-catenin in the cadherin-based adhesion complex

Biochemical journal, 2001-12, Vol.360 (Pt 2), p.335-344

2001

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Discovery of 6-Aryl-7-alkoxyisoquinoline Inhibitors of IKB Kinase-β (IKK-β)

Journal of medicinal chemistry, 2009, Vol.52 (9), p.3098-3102

2009

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Molecular basis for clinical diversity between autoantibody subsets in diffuse cutaneous systemic sclerosis

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

Four N-linked Glycosylation Sites in Human Toll-like Receptor 2 Cooperate to Direct Efficient Biosynthesis and Secretion

3D model of harlequin ichthyosis reveals inflammatory therapeutic targets

BET bromodomain inhibitors show anti-papillomavirus activity in vitro and block CRPV wart growth in vivo

Integrated analysis of dermal blister fluid proteomics and genome-wide skin gene expression in systemic sclerosis: an observational study

Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses

4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy

Discovery of 6-Aryl-7-alkoxyisoquinoline Inhibitors of IκB Kinase-β (IKK-β)

The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-α and IKK-β kinases

3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IKK-β

4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors

Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate

Development of an insect-cell-based assay for detection of kinase inhibition using NF-κB-inducing kinase as a paradigm

GRID: A Novel Grb-2-Related Adapter Protein That Interacts with the Activated T Cell Costimulatory Receptor CD28

P154 High-density proteomic analysis of skin blister fluid and plasma in systemic sclerosis identifies local and systemic differences for key proteins

3D model of harlequin ichthyosis reveals inflammatory therapeutic targets

P229 Integrated analysis of dermal blister fluid proteomics and skin biopsy transcriptomics gives new insight into pathogenesis of systemic sclerosis

O18 Integrated molecular analysis of systemic sclerosis skin and blood shows significant differences between major autoantibody subgroups

Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P 3 )-Sparing S1P 1 Agonists Active at Low Oral Doses

Targeting IKKβ for the treatment of rheumatoid arthritis

Discovery of a Brain-Penetrant S1P3-Sparing Direct Agonist of the S1P1 and S1P5 Receptors Efficacious at Low Oral Dose

3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IIK-β

The p85 subunit of phosphoinositide 3-kinase is associated with beta-catenin in the cadherin-based adhesion complex

Discovery of 6-Aryl-7-alkoxyisoquinoline Inhibitors of IKB Kinase-β (IKK-β)

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