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Itk kinase inhibitors: Initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (20), p.5537-5540

2008

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Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists

Bioorganic & medicinal chemistry, 2006-04, Vol.14 (8), p.2725-2746

2006

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Studies on the Synthesis of Nargenicin A1: Highly Stereoselective Synthesis of the Complete Carbon Framework via the Transannular Diels−Alder Reaction of an 18-Membered Macrolide

Journal of the American Chemical Society, 1996-08, Vol.118 (32), p.7502-7512

1996

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The synthesis and SAR of 2-amino-pyrrolo[2,3- d]pyrimidines: A new class of Aurora-A kinase inhibitors

Bioorganic & medicinal chemistry letters, 2006-11, Vol.16 (22), p.5778-5783

2006

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The Discovery of Orally Active Triaminotriazine Aniline Amides as Inhibitors of p38 MAP Kinase

Journal of medicinal chemistry, 2004-12, Vol.47 (25), p.6283-6291

2004

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Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (20), p.5545-5549

2008

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5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk)

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (20), p.5541-5544

2008

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Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry letters, 2006, Vol.16 (1), p.123-128

2006

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ChemInform Abstract: (E)-1-Tri-n-butylstannyl-2-trimethylsilylethylene

ChemInform, 2012-07, Vol.43 (27), p.no-no

Moriarty, Kevin J.

2012

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ChemInform Abstract: (E)-1-Trimethylsilyl-2-trimethylstannylethylene

ChemInform, 2012-07, Vol.43 (27), p.no-no

Moriarty, Kevin J.

2012

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Stereoselective synthesis of (Z,E)-2-bromo-1,3-dienes via the palladium (O) catalyzed cross coupling reactions of 1,1-dibromoolefins and vinylboronic acids

Tetrahedron letters, 1990, Vol.31 (45), p.6509-6512

1990

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Comprehensive Survey of Combinatorial Library Synthesis: 2005

Journal of combinatorial chemistry, 2006-09, Vol.8 (5), p.597-635

2006

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Enantioselective synthesis of the bottom half of chlorothricolide. 3. Studies of the steric directing group strategy for stereocontrol in intramolecular Diels-Alder reactions

Journal of organic chemistry, 1991-02, Vol.56 (3), p.1192-1210

1991

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A Novel Series of [2-[Methyl(2-phenethyl)amino]-2-oxoethyl]benzene-Containing Leukotriene B4 Antagonists: Initial Structure−Activity Relationships

Journal of medicinal chemistry, 1996-09, Vol.39 (19), p.3748-3755

1996

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4-[2-[Methyl(2-phenethyl)amino]-2-oxoethyl]-8-(phenylmethoxy)-2-naphthalenecarboxylic acid: a high affinity, competitive, orally active leukotriene B4 receptor antagonist

Journal of medicinal chemistry, 1992-10, Vol.35 (22), p.4253-4255

1992

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Structure−Activity Relationships Study of Two Series of Leukotriene B4 Antagonists: Novel Indolyl and Naphthyl Compounds Substituted with a 2-[Methyl(2-phenethyl)amino]-2-oxoethyl Side Chain

Journal of medicinal chemistry, 1996-09, Vol.39 (19), p.3756-3768

1996

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Stereoselective formation from a (1S,5S)-(-)-verbenone-derived cyclopentadiene of dimeric and mixed titanium and zirconium dichloride complexes

Organometallics, 1989-06, Vol.8 (6), p.1512-1517

1989

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Synthetic, x-ray structural and photoluminescence studies on pentamethylcyclopentadienyl derivatives of lanthanum, cerium and praseodymium

Organometallics, 1986-06, Vol.5 (6), p.1281-1283

1986

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Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist

Bioorganic & medicinal chemistry letters, 2005-01, Vol.15 (1), p.41-45

2005

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5-Aminomethyl-1 H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk)

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (20), p.5541-5544

2008

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5-Aminomethyl-lH-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk)

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (20), p.5541-5544

2008

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Isodicyclopentadienes and related molecules. 45. (1R)-(-)-Nopol as the source of an optically pure fused cyclopentadienyl ligand. Stereochemical course of complexation to cyclopentadienyltitanium and -zirconium dichloride fragments [Erratum to document cited in CA111(1):7549e]

Organometallics, 1990-05, Vol.9 (5), p.1706-1706

1990

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Discovery, SAR and X-ray structure of 1 H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (20), p.5545-5549

2008

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The formation, crystal and molecular structures of bis(η 5-indenyl)dicarbonyltitanium and bis(η 5-indenyl)dicarbonylzirconium

Journal of organometallic chemistry, 1987-06, Vol.327 (1), p.39-54

1987

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Itk kinase inhibitors: Initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead

Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists

Studies on the Synthesis of Nargenicin A1: Highly Stereoselective Synthesis of the Complete Carbon Framework via the Transannular Diels−Alder Reaction of an 18-Membered Macrolide

The synthesis and SAR of 2-amino-pyrrolo[2,3- d]pyrimidines: A new class of Aurora-A kinase inhibitors

The Discovery of Orally Active Triaminotriazine Aniline Amides as Inhibitors of p38 MAP Kinase

Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)

5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk)

Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors

ChemInform Abstract: (E)-1-Tri-n-butylstannyl-2-trimethylsilylethylene

ChemInform Abstract: (E)-1-Trimethylsilyl-2-trimethylstannylethylene

Stereoselective synthesis of (Z,E)-2-bromo-1,3-dienes via the palladium (O) catalyzed cross coupling reactions of 1,1-dibromoolefins and vinylboronic acids

Comprehensive Survey of Combinatorial Library Synthesis: 2005

Enantioselective synthesis of the bottom half of chlorothricolide. 3. Studies of the steric directing group strategy for stereocontrol in intramolecular Diels-Alder reactions

A Novel Series of [2-[Methyl(2-phenethyl)amino]-2-oxoethyl]benzene-Containing Leukotriene B4 Antagonists: Initial Structure−Activity Relationships

4-[2-[Methyl(2-phenethyl)amino]-2-oxoethyl]-8-(phenylmethoxy)-2-naphthalenecarboxylic acid: a high affinity, competitive, orally active leukotriene B4 receptor antagonist

Structure−Activity Relationships Study of Two Series of Leukotriene B4 Antagonists: Novel Indolyl and Naphthyl Compounds Substituted with a 2-[Methyl(2-phenethyl)amino]-2-oxoethyl Side Chain

Stereoselective formation from a (1S,5S)-(-)-verbenone-derived cyclopentadiene of dimeric and mixed titanium and zirconium dichloride complexes

Synthetic, x-ray structural and photoluminescence studies on pentamethylcyclopentadienyl derivatives of lanthanum, cerium and praseodymium

Corrigendum to “Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)” [Bioorg. Med. Chem. Lett. 18 (2008) 5545–5549]

Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist

5-Aminomethyl-1 H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk)

5-Aminomethyl-lH-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk)

Isodicyclopentadienes and related molecules. 45. (1R)-(-)-Nopol as the source of an optically pure fused cyclopentadienyl ligand. Stereochemical course of complexation to cyclopentadienyltitanium and -zirconium dichloride fragments [Erratum to document cited in CA111(1):7549e]

Discovery, SAR and X-ray structure of 1 H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)

The formation, crystal and molecular structures of bis(η 5-indenyl)dicarbonyltitanium and bis(η 5-indenyl)dicarbonylzirconium

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