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The design and development of pegfilgrastim (PEG-rmetHuG-CSF, Neulasta)

Current pharmaceutical design, 2004-04, Vol.10 (11), p.1235-1244

Molineux, G

2004

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Pegylation: Engineering Improved Biopharmaceuticals for Oncology

Pharmacotherapy, 2003-08, Vol.23 (8P2), p.3S-8S

Molineux, Graham

2003

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Pegfilgrastim: using pegylation technology to improve neutropenia support in cancer patients

Anti-cancer drugs, 2003-04, Vol.14 (4), p.259-264

Molineux, Graham

2003

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Mono-N-terminal poly(ethylene glycol)–protein conjugates

Advanced drug delivery reviews, 2002-06, Vol.54 (4), p.477-485

2002

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Transplantation Potential of Peripheral Blood Stem Cells Induced by Granulocyte Colony-Stimulating Factor

Blood, 1990-11, Vol.76 (10), p.2153-2158

1990

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CD34-Deficient Mice Have Reduced Eosinophil Accumulation After Allergen Exposure and Show a Novel Crossreactive 90-kD Protein

Blood, 1996-05, Vol.87 (9), p.3550-3562

1996

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A Comparison of Hematopoiesis in Normal and Splenectomized Mice Treated With Granulocyte Colony-Stimulating Factor

Blood, 1990-02, Vol.75 (3), p.563-569

1990

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The Effects on Hematopoiesis of Recombinant Stem Cell Factor (Ligand for c-kit) Administered In Vivo to Mice Either Alone or in Combination With Granulocyte Colony-Stimulating Factor

Blood, 1991-08, Vol.78 (4), p.961-966

1991

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Kinetics of Neutrophil Production in Normal and Neutropenic Animals during the Response to Filgrastim (r-metHu G-CSF) or Filgrastim SD/01 (PEG-r-metHu G-CSF)

Clinical cancer research, 2001-07, Vol.7 (7), p.2085-2090

2001

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Myeloid Cell Kinetics in Mice Treated With Recombinant Interleukin-3, Granulocyte Colony-Stimulating Factor (CSF), or Granulocyte-Macrophage CSF In Vivo

Blood, 1991-05, Vol.77 (10), p.2154-2159

1991

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A new form of Filgrastim with sustained duration in vivo and enhanced ability to mobilize PBPC in both mice and humans

Experimental hematology, 1999-12, Vol.27 (12), p.1724-1734

1999

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Prolonged neutropenia in a novel mouse granulocyte colony-stimulating factor neutralizing auto-immunoglobulin G mouse model

Experimental hematology, 2001, Vol.29 (1), p.59-67

2001

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Physiologic and pathologic consequences of granulocyte colony-stimulating factor deficiency

Current opinion in hematology, 2002-05, Vol.9 (3), p.199-201

Molineux, Graham

2002

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Darbepoietin alfa potentiates the efficacy of radiation therapy in mice with corrected or uncorrected anemia

Cancer research (Chicago, Ill.), 2005, Vol.65 (1), p.284-290

2005

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A comparison of potency of and intracellular signaling events provoked by, small molecule and protein-based mpl agonists

Journal of clinical oncology, 2009-05, Vol.27 (15_suppl), p.e14624-e14624

2009

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A cytokinetic Model Describes The Granulopoietic Effects of r-metHuG-CSF-SD/01 (SD/01) and The Homeostatic Regulation of SD/01 Clearance in Normal Volunteers

Clinical pharmacology and therapeutics, 1999-02, Vol.65 (2), p.196-196

1999

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Hemopoietic effects of short-term in vivo treatment of mice with various doses of rhG-CSF

Experimental hematology, 1990, Vol.18 (1), p.27-31

1990

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Long-term bone marrow damage in experimental systems and in patients after radiation or chemotherapy

Anticancer research, 1985-01, Vol.5 (1), p.101

1985

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Growth inhibitory effects of transforming growth factor-beta 1 in vivo

Growth factors (Chur, Switzerland), 1991, Vol.4 (3), p.239-245

1991

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Efficient mobilization of haematopoietic progenitors after a single injection of pegylated recombinant human granulocyte colony‐stimulating factor in mouse strains with distinct marrow‐cell pool sizes

British journal of haematology, 2000-09, Vol.110 (3), p.638-646

2000

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Flt-3 ligand synergizes with granulocyte colony-stimulating factor to increase neutrophil numbers and to mobilize peripheral blood stem cells with long-term repopulating potential

Blood, 1997-06, Vol.89 (11), p.3998-4004

1997

Volltextzugriff (PDF)

Repeated Hematopoietic Stem and Progenitor Cell Mobilization Without Depletion of the Bone Marrow Stem and Progenitor Cell Pool in Mice After Repeated Administration of Recombinant Murine G-CSF

Human immunology, 2007-05, Vol.68 (5), p.368-374

2007

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Effects of long-term in vivo treatment of mice with purified murine recombinant GM-CSF

Experimental hematology, 1989-12, Vol.17 (11), p.1100-1104

1989

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Kinetics of haematopoietic recovery after dose‐intensive chemo/radiotherapy in mice: optimized erythroid support with darbepoetin alpha

British journal of haematology, 2003-08, Vol.122 (4), p.623-636

2003

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Filgrastim (r-metHuG-CSF) in the 21st Century: SD/01

Acta haematologica, 2001-01, Vol.105 (3), p.151-155

2001

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The design and development of pegfilgrastim (PEG-rmetHuG-CSF, Neulasta)

Pegylation: Engineering Improved Biopharmaceuticals for Oncology

Pegfilgrastim: using pegylation technology to improve neutropenia support in cancer patients

Mono-N-terminal poly(ethylene glycol)–protein conjugates

Transplantation Potential of Peripheral Blood Stem Cells Induced by Granulocyte Colony-Stimulating Factor

CD34-Deficient Mice Have Reduced Eosinophil Accumulation After Allergen Exposure and Show a Novel Crossreactive 90-kD Protein

A Comparison of Hematopoiesis in Normal and Splenectomized Mice Treated With Granulocyte Colony-Stimulating Factor

The Effects on Hematopoiesis of Recombinant Stem Cell Factor (Ligand for c-kit) Administered In Vivo to Mice Either Alone or in Combination With Granulocyte Colony-Stimulating Factor

Kinetics of Neutrophil Production in Normal and Neutropenic Animals during the Response to Filgrastim (r-metHu G-CSF) or Filgrastim SD/01 (PEG-r-metHu G-CSF)

Myeloid Cell Kinetics in Mice Treated With Recombinant Interleukin-3, Granulocyte Colony-Stimulating Factor (CSF), or Granulocyte-Macrophage CSF In Vivo

A new form of Filgrastim with sustained duration in vivo and enhanced ability to mobilize PBPC in both mice and humans

Prolonged neutropenia in a novel mouse granulocyte colony-stimulating factor neutralizing auto-immunoglobulin G mouse model

Physiologic and pathologic consequences of granulocyte colony-stimulating factor deficiency

Darbepoietin alfa potentiates the efficacy of radiation therapy in mice with corrected or uncorrected anemia

A comparison of potency of and intracellular signaling events provoked by, small molecule and protein-based mpl agonists

A cytokinetic Model Describes The Granulopoietic Effects of r-metHuG-CSF-SD/01 (SD/01) and The Homeostatic Regulation of SD/01 Clearance in Normal Volunteers

Hemopoietic effects of short-term in vivo treatment of mice with various doses of rhG-CSF

Long-term bone marrow damage in experimental systems and in patients after radiation or chemotherapy

Growth inhibitory effects of transforming growth factor-beta 1 in vivo

Efficient mobilization of haematopoietic progenitors after a single injection of pegylated recombinant human granulocyte colony‐stimulating factor in mouse strains with distinct marrow‐cell pool sizes

Flt-3 ligand synergizes with granulocyte colony-stimulating factor to increase neutrophil numbers and to mobilize peripheral blood stem cells with long-term repopulating potential

Repeated Hematopoietic Stem and Progenitor Cell Mobilization Without Depletion of the Bone Marrow Stem and Progenitor Cell Pool in Mice After Repeated Administration of Recombinant Murine G-CSF

Effects of long-term in vivo treatment of mice with purified murine recombinant GM-CSF

Kinetics of haematopoietic recovery after dose‐intensive chemo/radiotherapy in mice: optimized erythroid support with darbepoetin alpha

Filgrastim (r-metHuG-CSF) in the 21st Century: SD/01

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