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Hippocampal and behavioral dysfunctions in a mouse model of environmental stress: normalization by agomelatine

Translational psychiatry, 2014-11, Vol.4 (11), p.e485-e485

2014

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Agomelatine: mechanism of action and pharmacological profile in relation to antidepressant properties

British journal of pharmacology, 2014-08, Vol.171 (15), p.3604-3619

2014

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Synergistic enhancing-memory effect of donepezil and S 47445, an AMPA positive allosteric modulator, in middle-aged and aged mice

Psychopharmacology, 2018-03, Vol.235 (3), p.771-787

2018

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The reduction in glutamate release is predictive of cognitive and emotional alterations that are corrected by the positive modulator of AMPA receptors S 47445 in perinatal stressed rats

Neuropharmacology, 2018-06, Vol.135, p.284-296

2018

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P.1.g.059 Further evidences of the efficacy of agomelatine in animal models of neuropathic pain

European neuropsychopharmacology, 2015-09, Vol.25, p.S268-S269

2015

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The positive modulator of AMPA receptors, S 47445, improved behavior, cognitive, neurochemical and synaptic proteins modifications induced by prenatal restraint stress

European neuropsychopharmacology, 2016-10, Vol.26, p.S447-S447

2016

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P.2.e.003 Effect of acute administration of agomelatine on the memory processes triggered by threat responses to an auditory stimulus in rats

European neuropsychopharmacology, 2015-09, Vol.25, p.S432-S433

2015

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Behavioral and neurochemical characterization of TrkB-dependent mechanisms of agomelatine in glucocorticoid receptor-impaired mice

European neuropsychopharmacology, 2016-01, Vol.26 (1), p.65-77

2016

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P.1.g.056 Potent and sustained anti-hyperalgesic and anti-allodynic effects of chronic administration of agomelatine in neuropathic rats

European neuropsychopharmacology, 2015-09, Vol.25, p.S267-S267

2015

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P.2.h.007 Neutrality of agomelatine on QT/QTc interval in healthy young volunteers: results from a randomised double-blind cross-over phase I study

European neuropsychopharmacology, 2013-10, Vol.23, p.S419-S419

2013

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EPA-0643 – Effect of agomelatine on reward and punishment processing in a probabilistic reversal learning task in mice; role of its MT1/MT2 agonist and 5HT2C antagonist properties

European psychiatry, 2014, Vol.29, p.1-1

2014

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P.1.h.025 Pharmacodynamic analyses of the anti-hyperalgesic and anti-allodynic effects of agomelatine in neuropathic rats

European neuropsychopharmacology, 2014-10, Vol.24, p.S284-S284

2014

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P.1.g.019 Antidepressant- and anxiolytic-like properties of S 47445, a novel positive allosteric modulator of AMPA type glutamate receptors

European neuropsychopharmacology, 2015-09, Vol.25, p.S248-S249

2015

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P.2.a.017 Behavioural and neurochemical characterisation of TrkB-dependent mechanisms of agomelatine in glucocorticoid receptor-impaired mice

European neuropsychopharmacology, 2014-10, Vol.24, p.S371-S371

2014

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Repeated restraint stress-induced atrophy of glutamatergic pyramidal neurons and decreases in glutamatergic efflux in the rat amygdala are prevented by the antidepressant agomelatine

Neuroscience, 2015-01, Vol.284, p.430-443

2015

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P.2.d.018 Agomelatine differentially modulates neuronal plasticity markers and MAP-2 in the rat PFC, hippocampus and amygdala

European neuropsychopharmacology, 2011, Vol.21, p.S411-S412

2011

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Organization of rat circadian rhythms during daily infusion of melatonin or S20098, a melatonin agonist

American journal of physiology. Regulatory, integrative and comparative physiology, 1999-09, Vol.277 (3), p.812-R828

1999

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Agomelatine, a New Antidepressant, Induces Regional Changes in Hippocampal Neurogenesis

Biological psychiatry (1969), 2006-06, Vol.59 (11), p.1087-1096

2006

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Better sexual acceptability of agomelatine (25 and 50 mg) compared with paroxetine (20 mg) in healthy male volunteers. An 8-week, placebo-controlled study using the PRSEXDQ-SALSEX scale

Journal of psychopharmacology (Oxford), 2010-01, Vol.24 (1), p.111-120

2010

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Mechanisms Contributing to the Phase-Dependent Regulation of Neurogenesis by the Novel Antidepressant, Agomelatine, in the Adult Rat Hippocampus

Neuropsychopharmacology, 2009-10, Vol.34 (11), p.2390-2403

2009

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P.2.b.012 Transcriptional changes of BDNF and clock genes in the rat prefrontal cortex following acute agomelatine administration

European neuropsychopharmacology, 2010, Vol.20, p.S360-S360

2010

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P.2.b.019 Agomelatine has antidepressant effects and modifies BDNF and neuronal plasticity markers in the rat PFC and hippocampus

European neuropsychopharmacology, 2010, Vol.20, p.S364-S364

2010

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P.2.d.019 Effects of chronic agomelatine administration on the expression of a panel of genes in various brain areas of rats

European neuropsychopharmacology, 2009, Vol.19, p.S440-S441

2009

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Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence

Pain (Amsterdam), 2017-01, Vol.158 (1), p.149-160

2017

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Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors

Journal of psychiatry & neuroscience, 2004-03, Vol.29 (2), p.126-133

2004

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Hippocampal and behavioral dysfunctions in a mouse model of environmental stress: normalization by agomelatine

Agomelatine: mechanism of action and pharmacological profile in relation to antidepressant properties

Synergistic enhancing-memory effect of donepezil and S 47445, an AMPA positive allosteric modulator, in middle-aged and aged mice

The reduction in glutamate release is predictive of cognitive and emotional alterations that are corrected by the positive modulator of AMPA receptors S 47445 in perinatal stressed rats

P.1.g.059 Further evidences of the efficacy of agomelatine in animal models of neuropathic pain

The positive modulator of AMPA receptors, S 47445, improved behavior, cognitive, neurochemical and synaptic proteins modifications induced by prenatal restraint stress

P.2.e.003 Effect of acute administration of agomelatine on the memory processes triggered by threat responses to an auditory stimulus in rats

Behavioral and neurochemical characterization of TrkB-dependent mechanisms of agomelatine in glucocorticoid receptor-impaired mice

P.1.g.056 Potent and sustained anti-hyperalgesic and anti-allodynic effects of chronic administration of agomelatine in neuropathic rats

P.2.h.007 Neutrality of agomelatine on QT/QTc interval in healthy young volunteers: results from a randomised double-blind cross-over phase I study

EPA-0643 – Effect of agomelatine on reward and punishment processing in a probabilistic reversal learning task in mice; role of its MT1/MT2 agonist and 5HT2C antagonist properties

P.1.h.025 Pharmacodynamic analyses of the anti-hyperalgesic and anti-allodynic effects of agomelatine in neuropathic rats

P.1.g.019 Antidepressant- and anxiolytic-like properties of S 47445, a novel positive allosteric modulator of AMPA type glutamate receptors

P.2.a.017 Behavioural and neurochemical characterisation of TrkB-dependent mechanisms of agomelatine in glucocorticoid receptor-impaired mice

Repeated restraint stress-induced atrophy of glutamatergic pyramidal neurons and decreases in glutamatergic efflux in the rat amygdala are prevented by the antidepressant agomelatine

P.2.d.018 Agomelatine differentially modulates neuronal plasticity markers and MAP-2 in the rat PFC, hippocampus and amygdala

Organization of rat circadian rhythms during daily infusion of melatonin or S20098, a melatonin agonist

Agomelatine, a New Antidepressant, Induces Regional Changes in Hippocampal Neurogenesis

Better sexual acceptability of agomelatine (25 and 50 mg) compared with paroxetine (20 mg) in healthy male volunteers. An 8-week, placebo-controlled study using the PRSEXDQ-SALSEX scale

Mechanisms Contributing to the Phase-Dependent Regulation of Neurogenesis by the Novel Antidepressant, Agomelatine, in the Adult Rat Hippocampus

P.2.b.012 Transcriptional changes of BDNF and clock genes in the rat prefrontal cortex following acute agomelatine administration

P.2.b.019 Agomelatine has antidepressant effects and modifies BDNF and neuronal plasticity markers in the rat PFC and hippocampus

P.2.d.019 Effects of chronic agomelatine administration on the expression of a panel of genes in various brain areas of rats

Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence

Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors

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