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Effect of Proton Pump Inhibitor Pretreatment on Resistance of Solid Tumors to Cytotoxic Drugs

JNCI : Journal of the National Cancer Institute, 2004-11, Vol.96 (22), p.1702-1713

2004

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Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells

Cell death & disease, 2010-10, Vol.1 (10), p.e87-e87

2010

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SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth

Cell death & disease, 2014-10, Vol.5 (10), p.e1483-e1483

2014

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The role of FAS to ezrin association in FAS-mediated apoptosis

Apoptosis (London), 2005-10, Vol.10 (5), p.941-947

2005

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Soluble CD27 induces IgG production through activation of antigen-primed B cells

Journal of internal medicine, 2012-03, Vol.271 (3), p.282-293

2012

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Plasma levels of soluble CD27: a simple marker to monitor immune activation during potent antiretroviral therapy in HIV‐1‐infected subjects

Clinical and experimental immunology, 2002-03, Vol.127 (3), p.486-494

2002

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Therapeutic implications of tumor interstitial acidification

Seminars in cancer biology, 2017-04, Vol.43, p.119-133

2017

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Fatal herpesvirus 6 encephalitis after unrelated bone marrow transplant

Bone marrow transplantation (Basingstoke), 1998-08, Vol.22 (3), p.285-288

1998

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Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes

Cancer research (Chicago, Ill.), 2012-06, Vol.72 (11), p.2746-2756

2012

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Proton channels and exchangers in cancer

Biochimica et biophysica acta, 2015-10, Vol.1848 (10), p.2715-2726

2015

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Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: implications for cancer therapies

Autophagy, 2014-04, Vol.10 (4), p.562-571

2014

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Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

Cancer letters, 2018-10, Vol.435, p.32-43

2018

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The Role of Autophagy in the Maintenance of Stemness and Differentiation of Mesenchymal Stem Cells

Stem Cell Reviews and Reports, 2016-12, Vol.12 (6), p.621-633

2016

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Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress

The Journal of biological chemistry, 2012-08, Vol.287 (36), p.30664-30676

2012

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Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy

Science advances, 2020-05, Vol.6 (18), p.eaax7881-eaax7881

2020

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Lighting up the fire in cold tumors to improve cancer immunotherapy by blocking the activity of the autophagy-related protein PIK3C3/VPS34

Autophagy, 2020-11, Vol.16 (11), p.2110-2111

2020

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Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Nature communications, 2014, Vol.5 (1), p.3295, Article 3295

2014

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Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance

Oncotarget, 2016-09, Vol.7 (39), p.63408-63423

2016

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Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors

International Journal of Molecular Sciences, 2015-11, Vol.16 (11), p.27313-27326

2015

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The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors

Oncoimmunology, 2013-01, Vol.2 (1), p.22-21

2013

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Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy

Cell death & disease, 2022-04, Vol.13 (4), p.398-398, Article 398

2022

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Pathobiology and Therapeutic Implications of Tumor Acidosis

Current medicinal chemistry, 2017-01, Vol.24 (26), p.2827

2017

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Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species

Cancer research (Chicago, Ill.), 2007-06, Vol.67 (11), p.5408-5417

2007

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Spheroid‐based 3D cell cultures identify salinomycin as a promising drug for the treatment of chondrosarcoma

Journal of orthopaedic research, 2018-08, Vol.36 (8), p.2305-2312

2018

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P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma

International journal of cancer, 2012-06, Vol.130 (12), p.2824-2834

2012

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Effect of Proton Pump Inhibitor Pretreatment on Resistance of Solid Tumors to Cytotoxic Drugs

Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells

SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth

The role of FAS to ezrin association in FAS-mediated apoptosis

Soluble CD27 induces IgG production through activation of antigen-primed B cells

Plasma levels of soluble CD27: a simple marker to monitor immune activation during potent antiretroviral therapy in HIV‐1‐infected subjects

Therapeutic implications of tumor interstitial acidification

Fatal herpesvirus 6 encephalitis after unrelated bone marrow transplant

Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes

Proton channels and exchangers in cancer

Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: implications for cancer therapies

Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

The Role of Autophagy in the Maintenance of Stemness and Differentiation of Mesenchymal Stem Cells

Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress

Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy

Lighting up the fire in cold tumors to improve cancer immunotherapy by blocking the activity of the autophagy-related protein PIK3C3/VPS34

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance

Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors

The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors

Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy

Pathobiology and Therapeutic Implications of Tumor Acidosis

Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species

Spheroid‐based 3D cell cultures identify salinomycin as a promising drug for the treatment of chondrosarcoma

P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma

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