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Fluorenylalkanoic and Benzoic Acids as Novel Inhibitors of Cell Adhesion Processes in Leukocytes

Journal of medicinal chemistry, 1995-05, Vol.38 (10), p.1650-1656

1995

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Studies towards the next generation of antidepressants. Part 1 : Indolylcyclohexylamines as potent serotonin reuptake inhibitors

Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (14), p.1885-1888

2001

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New Generation Dopaminergic Agents. 1. Discovery of a Novel Scaffold Which Embraces the D2 Agonist Pharmacophore. Structure−Activity Relationships of a Series of 2-(Aminomethyl)chromans

Journal of medicinal chemistry, 1997-12, Vol.40 (26), p.4235-4256

1997

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Application of comparative molecular field analysis to dopamine d2 partial agonists

Bioorganic & medicinal chemistry, 1999-11, Vol.7 (11), p.2453-2456

1999

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Evaluation of an Estrogen Receptor-β Agonist in Animal Models of Human Disease

Endocrinology (Philadelphia), 2003-10, Vol.144 (10), p.4241-4249

2003

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ERβ Ligands. 3. Exploiting Two Binding Orientations of the 2-Phenylnaphthalene Scaffold To Achieve ERβ Selectivity

Journal of medicinal chemistry, 2005-06, Vol.48 (12), p.3953-3979

2005

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New Generation Dopaminergic Agents. 6. Structure−Activity Relationship Studies of a Series of 4-(Aminoethoxy)indole and 4-(Aminoethoxy)indolone Derivatives Based on the Newly Discovered 3-Hydroxyphenoxyethylamine D2 Template

Journal of medicinal chemistry, 1999-06, Vol.42 (11), p.2007-2020

1999

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New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template

Bioorganic & medicinal chemistry letters, 1999-09, Vol.9 (17), p.2593-2598

1999

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ERβ ligands. Part 4: Synthesis and structure–activity relationships of a series of 2-phenylquinoline derivatives

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (20), p.4520-4525

2005

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Vilsmeier reagents: Preparation of β-halo-α,β-unsaturated ketones

Tetrahedron letters, 1989, Vol.30 (29), p.3753-3756

Mewshaw, Richard E.

1989

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Bridged .gamma.-carbolines and derivatives possessing selective and combined affinity for 5-HT2 and D2 receptors

Journal of medicinal chemistry, 1993-05, Vol.36 (10), p.1488-1495

1993

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Studies toward the Discovery of the Next Generation of Antidepressants. 3. Dual 5-HT1A and Serotonin Transporter Affinity within a Class of N-Aryloxyethylindolylalkylamines

Journal of medicinal chemistry, 2004-07, Vol.47 (15), p.3823-3842

2004

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Studies toward the discovery of the next generation of antidepressants. Part 5 : 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (5), p.1338-1341

2006

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ER β Ligands. Part 1: The discovery of ER β selective ligands which embrace the 4-hydroxy-biphenyl template

Bioorganic & medicinal chemistry, 2003-08, Vol.11 (16), p.3457-3474

2003

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SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF C-4 SUBSTITUTED MONOBACTAMS

The Journal of Antibiotics, 1987/11/25, Vol.40(11), pp.1563-1571

1987

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ERβ Ligands. Part 2: Synthesis and structure–activity relationships of a series of 4-hydroxy-biphenyl-carbaldehyde oxime derivatives

Bioorganic & medicinal chemistry, 2004-05, Vol.12 (10), p.2553-2570

2004

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New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH- N1-phenylpiperazine dopaminergic templates

Bioorganic & medicinal chemistry letters, 1998-02, Vol.8 (3), p.295-300

1998

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Novel anti-inflammatory compounds prevent CD11b/CD18, alpha M beta 2 (Mac-1)-dependent neutrophil adhesion without blocking activation-induced changes in Mac-1

The Journal of pharmacology and experimental therapeutics, 1996-01, Vol.276 (1), p.5

1996

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Examination of the D2/5-HT2 affinity ratios of resolved 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: an enantioselective approach toward the design of potential atypical antipsychotics

Journal of medicinal chemistry, 1993-10, Vol.36 (21), p.3073-3076

1993

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Studies towards the next generation of antidepressants. Part 4: Derivatives of 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine with affinity for the serotonin transporter and the 5-HT1A receptor

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (4), p.911-914

2005

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Studies toward the discovery of the next generation of antidepressants. Part 2: Incorporating a 5-HT1A antagonist component into a class of serotonin reuptake inhibitors

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (3), p.307-310

2002

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Novel aryloxy-8-azabicyclo[3.2.1]oct-3-enes with 5-ht transporter and 5-HT1A affinity

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (21), p.5281-5284

2004

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Synthesis of arylnaphthalenyl derivatives: inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme a reductase

Drug design and delivery, 1988-11, Vol.3 (3), p.235

1988

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New Generation Dopaminergic Agents. Part 8: Heterocyclic Bioisosteres that Exploit the 7-OH-2-(aminomethyl)chroman D 2 Template

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (3), p.271-274

2002

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New Generation Dopaminergic Agents. 1. Discovery of a Novel Scaffold Which Embraces the D 2 Agonist Pharmacophore. Structure−Activity Relationships of a Series of 2-(Aminomethyl)chromans

Journal of medicinal chemistry, 1997-12, Vol.40 (26), p.4235-4256

1997

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Fluorenylalkanoic and Benzoic Acids as Novel Inhibitors of Cell Adhesion Processes in Leukocytes

Studies towards the next generation of antidepressants. Part 1 : Indolylcyclohexylamines as potent serotonin reuptake inhibitors

New Generation Dopaminergic Agents. 1. Discovery of a Novel Scaffold Which Embraces the D2 Agonist Pharmacophore. Structure−Activity Relationships of a Series of 2-(Aminomethyl)chromans

Application of comparative molecular field analysis to dopamine d2 partial agonists

Evaluation of an Estrogen Receptor-β Agonist in Animal Models of Human Disease

ERβ Ligands. 3. Exploiting Two Binding Orientations of the 2-Phenylnaphthalene Scaffold To Achieve ERβ Selectivity

New Generation Dopaminergic Agents. 6. Structure−Activity Relationship Studies of a Series of 4-(Aminoethoxy)indole and 4-(Aminoethoxy)indolone Derivatives Based on the Newly Discovered 3-Hydroxyphenoxyethylamine D2 Template

New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template

ERβ ligands. Part 4: Synthesis and structure–activity relationships of a series of 2-phenylquinoline derivatives

Vilsmeier reagents: Preparation of β-halo-α,β-unsaturated ketones

Bridged .gamma.-carbolines and derivatives possessing selective and combined affinity for 5-HT2 and D2 receptors

Studies toward the Discovery of the Next Generation of Antidepressants. 3. Dual 5-HT1A and Serotonin Transporter Affinity within a Class of N-Aryloxyethylindolylalkylamines

Studies toward the discovery of the next generation of antidepressants. Part 5 : 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity

ER β Ligands. Part 1: The discovery of ER β selective ligands which embrace the 4-hydroxy-biphenyl template

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF C-4 SUBSTITUTED MONOBACTAMS

ERβ Ligands. Part 2: Synthesis and structure–activity relationships of a series of 4-hydroxy-biphenyl-carbaldehyde oxime derivatives

New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH- N1-phenylpiperazine dopaminergic templates

Novel anti-inflammatory compounds prevent CD11b/CD18, alpha M beta 2 (Mac-1)-dependent neutrophil adhesion without blocking activation-induced changes in Mac-1

Examination of the D2/5-HT2 affinity ratios of resolved 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: an enantioselective approach toward the design of potential atypical antipsychotics

Studies towards the next generation of antidepressants. Part 4: Derivatives of 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine with affinity for the serotonin transporter and the 5-HT1A receptor

Studies toward the discovery of the next generation of antidepressants. Part 2: Incorporating a 5-HT1A antagonist component into a class of serotonin reuptake inhibitors

Novel aryloxy-8-azabicyclo[3.2.1]oct-3-enes with 5-ht transporter and 5-HT1A affinity

Synthesis of arylnaphthalenyl derivatives: inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme a reductase

New Generation Dopaminergic Agents. Part 8: Heterocyclic Bioisosteres that Exploit the 7-OH-2-(aminomethyl)chroman D 2 Template

New Generation Dopaminergic Agents. 1. Discovery of a Novel Scaffold Which Embraces the D 2 Agonist Pharmacophore. Structure−Activity Relationships of a Series of 2-(Aminomethyl)chromans

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