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Preclinical characterization of selective phosphodiesterase 10A inhibitors: a new therapeutic approach to the treatment of schizophrenia

The Journal of pharmacology and experimental therapeutics, 2008-05, Vol.325 (2), p.681

2008

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The distribution of phosphodiesterase 2A in the rat brain

Neuroscience, 2012-12, Vol.226, p.145-155

2012

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Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase

Neuroscience, 2006-01, Vol.139 (2), p.597-607

2006

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Antagonists selective for NMDA receptors containing the NR2B subunit

Current pharmaceutical design, 1999-05, Vol.5 (5), p.381

1999

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The NR2B-selective NMDA receptor antagonist CP-101,606 exacerbates L-DOPA-induced dyskinesia and provides mild potentiation of anti-parkinsonian effects of L-DOPA in the MPTP-lesioned marmoset model of Parkinson's disease

Experimental neurology, 2004-08, Vol.188 (2), p.471-479

2004

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Antiparkinsonian actions of CP-101, 606, an antagonist of NR2B subunit-containing N-methyl-D-aspartate receptors

Experimental neurology, 2000-05, Vol.163 (1), p.239-243

2000

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Atropisomeric quinazolin-4-one derivatives are potent noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists

Bioorganic & medicinal chemistry letters, 2001-01, Vol.11 (2), p.177-181

2001

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Antinociceptive activity of CP‐101,606, an NMDA receptor NR2B subunit antagonist

British journal of pharmacology, 1997-11, Vol.122 (5), p.809-812

1997

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NR2B selective NMDA receptor antagonist CP-101,606 prevents levodopa-induced motor response alterations in hemi-parkinsonian rats

Neuropharmacology, 2004-08, Vol.47 (2), p.184-194

2004

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Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist

Neuropharmacology, 2002-02, Vol.42 (2), p.143-153

2002

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Turnover of inositol polyphosphate pyrophosphates in pancreatoma cells

The Journal of biological chemistry, 1993-02, Vol.268 (6), p.3850-3856

1993

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Quinazolin-4-one α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonists: Structure−Activity Relationship of the C-2 Side Chain Tether

Journal of medicinal chemistry, 2001-05, Vol.44 (11), p.1710-1717

2001

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(1S,2S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: A Potent New Neuroprotectant Which Blocks N-Methyl-D-Aspartate Responses

Journal of medicinal chemistry, 1995-08, Vol.38 (16), p.3138-3145

1995

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Immunohistochemical localization of PDE10A in the rat brain

Brain research, 2003-09, Vol.985 (2), p.113-126

2003

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Methaqualone derivatives are potent noncompetitive AMPA receptor antagonists

Bioorganic & medicinal chemistry letters, 2000-06, Vol.10 (11), p.1203-1205

2000

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CP-101,606, an NR2B subunit selective NMDA receptor antagonist, inhibits NMDA and injury induced c-fos expression and cortical spreading depression in rodents

Neuropharmacology, 2000-06, Vol.39 (7), p.1147-1155

2000

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Repeated Estradiol Treatment Prevents MPTP-Induced Dopamine Depletion in Male Mice

Neuroendocrinology, 2003-04, Vol.77 (4), p.223-231

2003

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(3R,4S)-3-[4-(4-Fluorophenyl)-4-hydroxypiperidin-1-yl]chroman-4,7-diol: A Conformationally Restricted Analogue of the NR2B Subtype-Selective NMDA Antagonist (1S,2S)-1-(4-Hydroxyphenyl)-2- (4-hydroxy-4-phenylpiperidino)-1-propanol

Journal of medicinal chemistry, 1998-03, Vol.41 (7), p.1172-1184

1998

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Different modes of regulation for receptors activating phospholipase C in the rat pancreatoma cell line AR4-2J

Molecular pharmacology, 1991-11, Vol.40 (5), p.727-733

1991

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Role of ascorbic acid in dopamine beta-hydroxylation. The endogenous enzyme cofactor and putative electron donor for cofactor regeneration

The Journal of biological chemistry, 1986-12, Vol.261 (36), p.16901-16908

1986

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Mobilization of calcium by inositol trisphosphates from permeabilized rat parotid acinar cells. Evidence for translocation of calcium from uptake to release sites within the inositol 1,4,5-trisphosphate- and thapsigargin-sensitive calcium pool

The Journal of biological chemistry, 1991-07, Vol.266 (21), p.13646-13653

1991

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CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo

Stroke (1970), 2003, Vol.34 (1), p.171-176

2003

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Characterization of the binding site for a novel class of noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists

Molecular pharmacology, 2000-12, Vol.58 (6), p.1310-1317

2000

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Phosphodiesterases in the CNS: targets for drug development

Nature reviews. Drug discovery, 2006-08, Vol.5 (8), p.660-670

2006

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Inositol phosphates and cell signaling: new views of InsP5 and InsP6

Trends in biochemical sciences (Amsterdam. Regular ed.), 1993-02, Vol.18 (2), p.53-56

1993

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Preclinical characterization of selective phosphodiesterase 10A inhibitors: a new therapeutic approach to the treatment of schizophrenia

The distribution of phosphodiesterase 2A in the rat brain

Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase

Antagonists selective for NMDA receptors containing the NR2B subunit

The NR2B-selective NMDA receptor antagonist CP-101,606 exacerbates L-DOPA-induced dyskinesia and provides mild potentiation of anti-parkinsonian effects of L-DOPA in the MPTP-lesioned marmoset model of Parkinson's disease

Antiparkinsonian actions of CP-101, 606, an antagonist of NR2B subunit-containing N-methyl-D-aspartate receptors

Atropisomeric quinazolin-4-one derivatives are potent noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists

Antinociceptive activity of CP‐101,606, an NMDA receptor NR2B subunit antagonist

NR2B selective NMDA receptor antagonist CP-101,606 prevents levodopa-induced motor response alterations in hemi-parkinsonian rats

Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist

Turnover of inositol polyphosphate pyrophosphates in pancreatoma cells

Quinazolin-4-one α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonists: Structure−Activity Relationship of the C-2 Side Chain Tether

(1S,2S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: A Potent New Neuroprotectant Which Blocks N-Methyl-D-Aspartate Responses

Immunohistochemical localization of PDE10A in the rat brain

Methaqualone derivatives are potent noncompetitive AMPA receptor antagonists

CP-101,606, an NR2B subunit selective NMDA receptor antagonist, inhibits NMDA and injury induced c-fos expression and cortical spreading depression in rodents

Repeated Estradiol Treatment Prevents MPTP-Induced Dopamine Depletion in Male Mice

(3R,4S)-3-[4-(4-Fluorophenyl)-4-hydroxypiperidin-1-yl]chroman-4,7-diol: A Conformationally Restricted Analogue of the NR2B Subtype-Selective NMDA Antagonist (1S,2S)-1-(4-Hydroxyphenyl)-2- (4-hydroxy-4-phenylpiperidino)-1-propanol

Different modes of regulation for receptors activating phospholipase C in the rat pancreatoma cell line AR4-2J

Role of ascorbic acid in dopamine beta-hydroxylation. The endogenous enzyme cofactor and putative electron donor for cofactor regeneration

Mobilization of calcium by inositol trisphosphates from permeabilized rat parotid acinar cells. Evidence for translocation of calcium from uptake to release sites within the inositol 1,4,5-trisphosphate- and thapsigargin-sensitive calcium pool

CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo

Characterization of the binding site for a novel class of noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists

Phosphodiesterases in the CNS: targets for drug development

Inositol phosphates and cell signaling: new views of InsP5 and InsP6

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